U5754
Sigma

Urodilatin human

≥97% (HPLC)

Synonym

Thr-Ala-Pro-Arg-Atrial Natriuretic Peptide

Amino Acid Sequence

Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide Bridge: 11-27]

Molecular Formula

C₁₄₅H₂₃₄N₅₂O₄₄S₃

Molecular Weight

3505.93

CAS Number

115966-23-9

MDL number

MFCD00076227

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Descriptions

Biochem/physiol Actions

Urodilatin is a natriuretic factor that is produced in the kidney and secreted into the urine. It regulates water and sodium reabsorption in the collecting duct.

Properties

assay

≥97% (HPLC)

composition

Peptide content, ~70%

Gene Information

human ... NPPA(4878)

storage temp.

−20°C

References

Reference

Forssmann, W.G., et al., The endocrine heart and natriuretic peptides: histochemistry, cell biology, and functional aspects of the renal urodilatin system. Histochem. Cell Biol. 110, 335-357, (1998) abstract

Bailly, C., Transducing pathways involved in the control of NaCl reabsorption in the thick ascending limb of Henle's loop. Kidney Int. (Suppl.) 65, S29-S35, (1998) abstract

Heringlake, M., et al., Urinary excretion of urodilatin is increased during pressure natriuresis in the isolated perfused rat kidney. Am. J. Physiol. 277, F347-F351, (1999) abstract

Safety

WGK Germany

Related Categories

... Neuropeptides > Natriuretic Peptides

... Peptides for Cell Biology > Natriuretic Peptides

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