U6756
Sigma

U-73122

≥98% (HPLC), solid

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Synonym

1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione

Molecular Formula

C₂₉H₄₀N₂O₃

Molecular Weight

464.64

CAS Number

112648-68-7

MDL number

MFCD00893825

PubChem Substance ID

24278065

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Descriptions

Biochem/physiol Actions

Inhibits the hydrolysis of PPI to IP₃, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.

Properties

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

ethanol: 0.7 mg/mL

DMSO: 0.9 mg/mL

References

Reference

Yule, et al., U73122 inhibits Ca²⁺ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J. Biol. Chem. 267, 13830-13835, (1992) abstract

Bleasdale, et al., Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J. Pharmacol. Exp. Ther. 255, 756, (1990) abstract

Smallridge, et al., U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells. Endocrinology 131, 1883-1888, (1992) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Related Categories

... P to Q > Phospholipase A 2

... P to Q > Phospholipase C

... Phospholipid Metabolism > Phospholipase Inhibitors

U6756 - Product Information Sheet (25kb)

MSDS

Certificate of Analysis

More Information