U8007
Sigma

UDP-Glucuronosyltransferase SF9WT Negative Control Microsomes

buffered aqueous solution

MDL number

MFCD03458921

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Descriptions

Analysis Note

Glucuronidation of octyl gallate and α-naphthol is not observed.

Application

Negative control for the UDP-glucuronosyltransferase microsomal preparations.

Other Notes

Wild type control

Physical form

Microsome fractions in 100 mM potassium phosphate buffer, pH 7.4, containing 20% (v/v) glycerol, 0.1 mM EDTA, and 1 mM DTT.

Biochem/physiol Actions

The UDP-Glucuronosyltransferases (UGT) comprise a family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups.

Properties

form

buffered aqueous solution

Gene Information

human ... UGT1A1(54658)

shipped in

dry ice

storage temp.

−70°C

References

Reference

King, C.D., et al., UDP-glucuronosyltransferases. Curr. Drug Metab. 1, 143, (2000)

Mackenzie, P.I. et al., Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance. Clin. Chem. Lab Med. 38, 889, (2000)

Tukey, R.H., Strassburg, C.P., Human UDP-glucuronosyltransferases: metabolism, expression, and disease. . Annu. Rev. Pharmacol. Toxicol. 40, 581, (2000)

Safety

WGK Germany

Related Categories

... Drug and Xenobiotic Metabolism > Conjugate Pathway

... Xenobiotics and Drug Metabolism > UDP-glycosyltransferase (UGT)

... 2.x.x.x Transferases > 2.4.x.x Glycosyltransferases

MSDS

Certificate of Analysis

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U8007 (Sigma)