V7139
Sigma

Vacuolin-1

≥98% (HPLC), solid

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Synonym

3-Iodobenzaldehyde[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone

Molecular Formula

C₂₆H₂₄IN₇O

Molecular Weight

577.42

CAS Number

351986-85-1

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Descriptions

Biochem/physiol Actions

Vacuolin-1 alters the morphology of lysosomes, but not cell resealing

Properties

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H₂O: <2 mg/mL

DMSO: >5 mg/mL

storage temp.

2-8°C

References

Reference

Huynh, C. and Andrews, N.W., The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis EMBO Rep. 6, 843-847, (2005) abstract

Cerny, J., et al., The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing EMBO Rep. 5, 883-888, (2004) abstract

Theos, A.C., et al., A novel pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis Dev. Cell 10, 343-354, (2006) abstract

Safety

Hazard Codes

Risk Statements

Related Categories

... Cell Signaling and Neuroscience > Chemical Biology

... Cytoskeleton and Extracellular Matrix > Organelle Proteins and Related Molecules

MSDS

Certificate of Analysis

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V7139 (Sigma)