W3763
Sigma

WP631 methanesulfonate

≥97% (HPLC), solid

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Molecular Formula

C₆₂H₆₄N₂O₂₀ � C₂H₈S₂O₆

Molecular Weight

1349.38

MDL number

MFCD04041200

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Descriptions

Biochem/physiol Actions

Fluorescent bisintercalating anthracycline antibiotic. Inhibits basal transcription by RNA polymerase II.

Caution

Salt content may vary, please see certificate of analysis.

Properties

assay

≥97% (HPLC)

form

solid

color

dark red

solubility

DMSO: >5 mg/mL, soluble

H₂O: insoluble

storage temp.

−20°C

References

Reference

Chaires, J .B., et al., Structure-based design of a new bisintercalating anthracycline antibiotic. J. Med. Chem. J. Med. Chem. 40, 261-266, (1997)

Portugal, J., et al., Analysis of the effects of daunorubicin and WP631 on transcription. Curr. Med. Chem. 8, 1-8, (2001)

Silvia Villamarin, S., et al., Induction of G₂/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes. Biochem. Pharmacol. 63, 1251-1258, (2002)

Gaidarova, S., and Jimenez, S.A., Inhibition of Basal and Transforming Growth Factor-beta -induced Stimulation of COL1A1 Transcription by the DNA Intercalators, Mitoxantrone and WP631, in Cultured Human Dermal Fibroblasts. J. Biol. Chem. 277, 38737-38745, (2002)

Martin, B., et al., Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro. Nucleic Acids Res. 27, 3402-3409, (1999)

Safety

Hazard Codes

Risk Statements

20/21/22

Safety Statements

26-36/37/39-45

WGK Germany