| Z370010 Sigma |
Antisense Therapeutics |
General description
An authoritative survey of this fascinating strategy for drug discovery: using complementary oligonucleotides to block expression of disease-associated genes. Contributors discuss selection of gene targets, synthesis of oligonucleotides, routes of administration, and issues of pharmacokinetics. Current research on anti-viral drugs, cancer treatment, and therapies for genetic disorders is summarized.
Table of Contents
History of Antisense Oligonucleotides.
Pharmacology of Antisense Therapeutic Agents: Cancer and Inflammation.
Antisense Efficacy: Site-Restricted In Vivo and Ex Vivo Models.
Antisense Blockade of Expression: SNAP-25 In Vitro and In Vivo.
Antisense Tumor Therapy: Activated C-Ha-ras Oncogene in the Mouse.
Antisense Inhibition of Protein Synthesis and Function: Rabbit Retinal Protein.
c-Myb in Smooth Muscle Cells.
Antisense Therapy of Hepatitis B Virus Infection: In Vivo Analyses in the Duck Hepatitis B Virus Model.
Antisense-Mediated Inhibition of Protein Synthesis: Rational Drug Design, Pharmacokinetics, Intracerebral Application, and Organ Uptake of Phosphorothioate Oligodeoxynucleotides.
Antisense rel A in Cancer.
Continuous Infusion of Antisense Phosphorothioate Therapeutics.
Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo: The Antisense Effects Outlast Antisense Survival.
Antisense Therapeutics in the Central Nervous System: The Induction of c-fos.
Comparative Pharmacokinetics of Antisense Oligonucleotides.
Index.
Pharmacology of Antisense Therapeutic Agents: Cancer and Inflammation.
Antisense Efficacy: Site-Restricted In Vivo and Ex Vivo Models.
Antisense Blockade of Expression: SNAP-25 In Vitro and In Vivo.
Antisense Tumor Therapy: Activated C-Ha-ras Oncogene in the Mouse.
Antisense Inhibition of Protein Synthesis and Function: Rabbit Retinal Protein.
c-Myb in Smooth Muscle Cells.
Antisense Therapy of Hepatitis B Virus Infection: In Vivo Analyses in the Duck Hepatitis B Virus Model.
Antisense-Mediated Inhibition of Protein Synthesis: Rational Drug Design, Pharmacokinetics, Intracerebral Application, and Organ Uptake of Phosphorothioate Oligodeoxynucleotides.
Antisense rel A in Cancer.
Continuous Infusion of Antisense Phosphorothioate Therapeutics.
Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo: The Antisense Effects Outlast Antisense Survival.
Antisense Therapeutics in the Central Nervous System: The Induction of c-fos.
Comparative Pharmacokinetics of Antisense Oligonucleotides.
Index.
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