| Z700711 Sigma |
Apoptosis and Autoimmunity: From Mechanisms to Treatments |
General description
This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.
Table of Contents
PART 1: GENERAL FEATURES OF APOPTOSIS.
Apoptosis and Autoimmunity
Caspase Knockouts: Matters of Life and Death
PART 2: CLEARANCE OF APOPTOTIC CELLS.
Anti-inflammatory and Immunoregulatory Effects of Apoptotic Cells
Complement and Apoptosis
Soluble Factors that Bind to Dying Cells Control the Outcome of Corpse Disposal: The Role of Pentraxins, Collectins and Autoantibodies
The Role of ATP-binding Cassette Transporters in the Clearance of Apoptotic Cells: A Tale of Two Systems
Innate Immunity and Apoptosis: CD14-dependent Clearance of Apoptotic Cells
PART 3: AUTOIMMUNITY CAUSED BY DEFECTIVE EXECUTION OF APOPTOSIS OR DEFECTIVE CLEARANCE OF APOPTOTIC CELLS.
Autoimmune Lymphoproliferative Syndromes (ALPS)
Infection and Inflammation as Cofactors for Autoimmunity of Systemic Lupus Erythematosus Patients
Apoptosis in Rheumatoid Arthritis
Systemic Lupus Erythematosus
PART 4: IMMUNOGENICITY OF APOPTOTIC CELLS.
Dendritic Cells Pulsed with Apoptotic Tumor Cells as Vaccines
The Immune Response against Apoptotic Cells
PART 5: "ALTERED SELF" IN DYING CELLS.
Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease
Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity
'Tissue' Transglutaminase and Autoimmunity
Modification of RNA - Antigens in apoptosis
PART 6: THE ROLE OF DNA BINDING PROTEINS FOR SYSTEMIC AUTOIMMUNITY.
Nucleosomes and Anti-Nucleosome Autoantibodies as Mediators of Glomerular Pathology in Systemic Lupus Erythematosus
Glossary.
Apoptosis and Autoimmunity
Caspase Knockouts: Matters of Life and Death
PART 2: CLEARANCE OF APOPTOTIC CELLS.
Anti-inflammatory and Immunoregulatory Effects of Apoptotic Cells
Complement and Apoptosis
Soluble Factors that Bind to Dying Cells Control the Outcome of Corpse Disposal: The Role of Pentraxins, Collectins and Autoantibodies
The Role of ATP-binding Cassette Transporters in the Clearance of Apoptotic Cells: A Tale of Two Systems
Innate Immunity and Apoptosis: CD14-dependent Clearance of Apoptotic Cells
PART 3: AUTOIMMUNITY CAUSED BY DEFECTIVE EXECUTION OF APOPTOSIS OR DEFECTIVE CLEARANCE OF APOPTOTIC CELLS.
Autoimmune Lymphoproliferative Syndromes (ALPS)
Infection and Inflammation as Cofactors for Autoimmunity of Systemic Lupus Erythematosus Patients
Apoptosis in Rheumatoid Arthritis
Systemic Lupus Erythematosus
PART 4: IMMUNOGENICITY OF APOPTOTIC CELLS.
Dendritic Cells Pulsed with Apoptotic Tumor Cells as Vaccines
The Immune Response against Apoptotic Cells
PART 5: "ALTERED SELF" IN DYING CELLS.
Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease
Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity
'Tissue' Transglutaminase and Autoimmunity
Modification of RNA - Antigens in apoptosis
PART 6: THE ROLE OF DNA BINDING PROTEINS FOR SYSTEMIC AUTOIMMUNITY.
Nucleosomes and Anti-Nucleosome Autoantibodies as Mediators of Glomerular Pathology in Systemic Lupus Erythematosus
Glossary.
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