| Z701467 Sigma |
Cytokine Knockouts, 2nd ed. |
General description
Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.
Table of Contents
PART I. Cytokine Knockouts in Models of Human Disease
1. Cytokine Knockouts in Inflammation
2. The Use of Cytokine Knockouts to Study Host Defense Against Infection
3. THe Use of Cytokine Knockouts in Animal Models of Autoimmune Disease
4. The Use of Cytokine Knockout Mice in Cancer Research
5. The Use of Cytokine Knockout Mice in Neuroimmunology
PART II. Cytokine Knockout Mice
6. The Role of IL-1 in the Immune System
7. IL-1 Receptor Antagonist Deficient Mice
8. A Unique Role for IL-2 in Self-Tolerance
9. Molecular Basis for Binding Multiple Cytokines by c: Implications for X-SCID and Impaired c-Dependent Cytokine Receptor Function
10. G-CSF, GM-CSF, and IL-3 Knockout Mice
11. IL-4 Knockout Mice
12. Role of IL-5 in Immune and Pathological Responses in the Mouse
13. Il-6 Knockout Mice
14. IL-10 and IL-12 Knockout Mice
15. IL-12 Deficient Mice
16. Il-13 and Double IL-4/IL-13 Knockout Mice
17. Il-15: Insights from Characterizaing IL-15 Deficient Mice
18. Il-18 and IL-18 Receptor Knockout Mice
19. Mice Knockouts for Chemokines and Chemokine Receptors
20. IFN- and IFN- Receptor Knockout Mice
21. Macrophage Migration Inhibitory Factor (MIF) Deficient Mice
22. Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice
23. RANKL, RANK, and OPG
24. Targeting the TGF- Pathway IN Vivo: Defining Complex Roles for TGF- Signaling in Immune Function, Wound Healing and Carcinogenesis
25. Physiologic Roles of Members of the TNF and TNF REceptor Families as REvealed by Knockout Models
1. Cytokine Knockouts in Inflammation
2. The Use of Cytokine Knockouts to Study Host Defense Against Infection
3. THe Use of Cytokine Knockouts in Animal Models of Autoimmune Disease
4. The Use of Cytokine Knockout Mice in Cancer Research
5. The Use of Cytokine Knockout Mice in Neuroimmunology
PART II. Cytokine Knockout Mice
6. The Role of IL-1 in the Immune System
7. IL-1 Receptor Antagonist Deficient Mice
8. A Unique Role for IL-2 in Self-Tolerance
9. Molecular Basis for Binding Multiple Cytokines by c: Implications for X-SCID and Impaired c-Dependent Cytokine Receptor Function
10. G-CSF, GM-CSF, and IL-3 Knockout Mice
11. IL-4 Knockout Mice
12. Role of IL-5 in Immune and Pathological Responses in the Mouse
13. Il-6 Knockout Mice
14. IL-10 and IL-12 Knockout Mice
15. IL-12 Deficient Mice
16. Il-13 and Double IL-4/IL-13 Knockout Mice
17. Il-15: Insights from Characterizaing IL-15 Deficient Mice
18. Il-18 and IL-18 Receptor Knockout Mice
19. Mice Knockouts for Chemokines and Chemokine Receptors
20. IFN- and IFN- Receptor Knockout Mice
21. Macrophage Migration Inhibitory Factor (MIF) Deficient Mice
22. Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice
23. RANKL, RANK, and OPG
24. Targeting the TGF- Pathway IN Vivo: Defining Complex Roles for TGF- Signaling in Immune Function, Wound Healing and Carcinogenesis
25. Physiologic Roles of Members of the TNF and TNF REceptor Families as REvealed by Knockout Models
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