| Z701718 Sigma |
Bioinformatics and Functional Genomics |
General description
Encompassing the field of bioinformatics, from sequence analysis, gene expression, microarrays, and proteomics to molecular phylogenics and whole genome studies, this text shows how bioinformatics applies to biological questions at different levels, such as gene/protein, disease, and protein structures. The author emphasizes practical skills, such as how to analyze genes and proteins, how to make trees using phylogenic software, how to extract data, and how to identify genes and proteins implicated in disease. It provides a systematic three-part format, beginning with the analysis of biological sequence data, continuing with functional genomics (from microarrays to proteomics), and ending with coverage of genomes.
Table of Contents
PART I: ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES.
1. Introduction.
2. Access to Sequence Data and Literature Information.
3. Pairwise Sequence Alignment.
4. Basic Local Alignmnet Search Tool (BLAST).
5. Advanced BLAST Searching.
PART II: GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.
6. Bioinformatic Approaches to Gene Expression.
7. Gene Expression: Microarrays Data Analysis.
8. Protein Analysis and Proteomics.
9. Protein Structure.
10. Multiple Sequence Alignment.
11. Molecular Phylogeny and Evolution.
PART III: GENOME ANALYSIS.
12. Completed Genomes and the Tree of Life.
13. Completed Genomes: Viruses.
14. Completed Genomes: Bacteria and Archaea.
15. Eukaryotic Genomes: Fungi
16. Eukaryotic Genomes: From Parasites to Primates.
17. The Human Genome.
18. Human Disease.
Epilogue.
Appendix: GCG for Protein and DNA Analysis.
Glossary.
Solutions to Self-Test Quizzes.
Subject Index.
1. Introduction.
2. Access to Sequence Data and Literature Information.
3. Pairwise Sequence Alignment.
4. Basic Local Alignmnet Search Tool (BLAST).
5. Advanced BLAST Searching.
PART II: GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.
6. Bioinformatic Approaches to Gene Expression.
7. Gene Expression: Microarrays Data Analysis.
8. Protein Analysis and Proteomics.
9. Protein Structure.
10. Multiple Sequence Alignment.
11. Molecular Phylogeny and Evolution.
PART III: GENOME ANALYSIS.
12. Completed Genomes and the Tree of Life.
13. Completed Genomes: Viruses.
14. Completed Genomes: Bacteria and Archaea.
15. Eukaryotic Genomes: Fungi
16. Eukaryotic Genomes: From Parasites to Primates.
17. The Human Genome.
18. Human Disease.
Epilogue.
Appendix: GCG for Protein and DNA Analysis.
Glossary.
Solutions to Self-Test Quizzes.
Subject Index.
Related Information
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