| Z702218 Sigma |
Human Molecular Genetics 3 |
General description
This book provides a complete account of human molecular genetics in the post-genome era, from basic principles to current practice. It is designed to engage readers with detailed full-color illustrations, special topic boxes (coverage of ethical, legal and social issues) and a constant emphasis on understanding principles rather than memorizing detail. Initial chapters cover DNA structure and function, chromosomes, pedigrees and the basic techniques of PCR, cloning and hybridization, and include a new chapter on cells and development. Later chapters detail new understanding of the structure, organization, expression and evolution of the human genome. Final sections cover functional genomics, the role of animal models and new approaches to genetic treatment of disease.
Table of Contents
PART 1: THE BASICS
Chapter 1: DNA Structure and Gene Expression
Chapter 2: Chromosome Structure and Function
Chapter 3: Cells and Development
Chapter 4: Genes in Pedigrees and Population
Chapter 5: Amplifying DNA: PCR and Cell-based DNA Cloning
Chapter 6: Nucleic Acid Hybridisation: Principles and Applications
Chapter 7: Analyzing DNA and Gene Structure, Variation and Expression
PART 2: THE HUMAN GENOME AND ITS RELATIONSHIP TO OTHER GENOMES
Chapter 8: Genome Projects and Model Organisms
Chapter 9: Organization of the Human Genome
Chapter 10: Human Gene Expression
Chapter 11: Instability of the Human Genome: Mutation and DNA Repair
Chapter 12: Our Place in the Tree of Life
PART 3: MAPPING AND I.D.ENTIFYING DISEASE GENES AND MUTATIONS
Chapter 13: Genetic Mapping of Mendelian Characters
Chapter 14: Identifying Human Disease Genes
Chapter 15: Mapping and Identifying Genes Conferring Susceptibility to Complex Diseases
Chapter 16: Molecular Pathology
Chapter 17: Cancer Genetics
Chapter 18: Genetic Testing in Individuals and Populations
PART 4: NEW HORIZONS: THE 21ST CENTURY AND BEYOND
Chapter 19: Beyond the Genome Project: Functional Genomics, Proteomics and Bioinformatics
Chapter 20: Genetic Manipulation of Cells and Animals
Chapter 21: Novel Approaches to Treating Disease
Chapter 1: DNA Structure and Gene Expression
Chapter 2: Chromosome Structure and Function
Chapter 3: Cells and Development
Chapter 4: Genes in Pedigrees and Population
Chapter 5: Amplifying DNA: PCR and Cell-based DNA Cloning
Chapter 6: Nucleic Acid Hybridisation: Principles and Applications
Chapter 7: Analyzing DNA and Gene Structure, Variation and Expression
PART 2: THE HUMAN GENOME AND ITS RELATIONSHIP TO OTHER GENOMES
Chapter 8: Genome Projects and Model Organisms
Chapter 9: Organization of the Human Genome
Chapter 10: Human Gene Expression
Chapter 11: Instability of the Human Genome: Mutation and DNA Repair
Chapter 12: Our Place in the Tree of Life
PART 3: MAPPING AND I.D.ENTIFYING DISEASE GENES AND MUTATIONS
Chapter 13: Genetic Mapping of Mendelian Characters
Chapter 14: Identifying Human Disease Genes
Chapter 15: Mapping and Identifying Genes Conferring Susceptibility to Complex Diseases
Chapter 16: Molecular Pathology
Chapter 17: Cancer Genetics
Chapter 18: Genetic Testing in Individuals and Populations
PART 4: NEW HORIZONS: THE 21ST CENTURY AND BEYOND
Chapter 19: Beyond the Genome Project: Functional Genomics, Proteomics and Bioinformatics
Chapter 20: Genetic Manipulation of Cells and Animals
Chapter 21: Novel Approaches to Treating Disease
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