Order Center
 
Z702501 
Sigma 

DNA Repair in Cancer Therapy 

 
  1 of 1  
      
 
General description  
The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies

 
 
Expand/Collapse All
Price and Availability
Identifiers
ISBN-10 
1-58829298-3

 
ISBN-13 
978-1-58829298-8
 
Properties
publication info 
L. Panasci and M. Alaoui-Jamali, Humana Press, 2004, 360 pp., hard cover
Table of Contents
1. Clinical Resistance to Alkylations: Status and Perspectives
2. Role of Nonhomologous End-Joining and Recombinant DNA Repair in Resistanct to Nitrogen Mustard and DNA Crosslinking Agents
3. Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs
4. Chemosensitization to Platinum Based Anticancer Drugs: Current Trends and Future Prospects
5. Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells
6. Stress-Activated Signal Transduction Pathways in DNA Damage Response: Implications for Repair, Arrest and Therapeutic Interventions
7. Overcoming Resistance to Alkylating Agents by Inhibitors of O6-Alkylguanine-DNA Alkyltransferase
8. Cellular Protection Against the Antitumor Drug Bleomycin
9. Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death
10. Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissue to Radiotherapy
Related Categories

 
   Related Information
 
MSDS
 
Certificate of Analysis

 
 
 
More Information
 
   Links
 
 
Related Categories
Page Options
 
Printer Friendly View
 
 
Ask A Scientist
 
Email Page
 

Last 5 Products Viewed
 
Z702501 (Sigma)




 Site Use Terms | Terms and Conditions of Sale | Privacy |
Copyrights © 2008 Sigma-Aldrich Co. All Rights Reserved. Reproduction of any materials from the site is strictly forbidden without permission. Sigma-Aldrich brand products are sold exclusively through Sigma-Aldrich, Inc.