| Z702595 Sigma |
A-β Metabolism and Alzheimer’s Disease |
General description
This book explores the aggregation of amyloid-β peptide in the brain which plays a primary role in the pathogenesis of Alzheimer’s disease. It provides current information regarding generation, degradation within the brain, and transport out of the brain.
Table of Contents
1. Overview -- Aβ Metabolism: From Alzheimer Research to Brain Aging Control
2. β-secretase: Progress and Open Questions
3. APP α-Secretase, a Novel Target for Alzheimer Drug Therapy
4. γ-Secretase and Presenilin
5. Functional Roles of APP Secretases
6. Proteolytic Degradation of Aβ by Neprilysin and Other Peptidases
7. Aβ Degradation by Endothelin-Converting Enzymes
8. Aβ Metabolism in Cholesterol Enriched Membrane Microdomains
9. Amyloid β-Protein in Low Density Membrane Domains
10. Transport Clearance Hypothesis for Alzheimer's Desease and Potential Therapeutic Implications
11. Potential Role of Endogenous and Exogenous Aβ Clearance and Metabolism
12. Modulating Amyloid-β Levels by Immunotherapy: A Potential Therapeutic Strategy for the Prevention and Treatment of Alzheimer's Disease
Index
2. β-secretase: Progress and Open Questions
3. APP α-Secretase, a Novel Target for Alzheimer Drug Therapy
4. γ-Secretase and Presenilin
5. Functional Roles of APP Secretases
6. Proteolytic Degradation of Aβ by Neprilysin and Other Peptidases
7. Aβ Degradation by Endothelin-Converting Enzymes
8. Aβ Metabolism in Cholesterol Enriched Membrane Microdomains
9. Amyloid β-Protein in Low Density Membrane Domains
10. Transport Clearance Hypothesis for Alzheimer's Desease and Potential Therapeutic Implications
11. Potential Role of Endogenous and Exogenous Aβ Clearance and Metabolism
12. Modulating Amyloid-β Levels by Immunotherapy: A Potential Therapeutic Strategy for the Prevention and Treatment of Alzheimer's Disease
Index
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