General description
This text offers a comprehensive account of the structural classes of antibiotics. While most of the attention is on natural products, synthetic chemicals with antibiotic activity are also discussed. The book contains a section that examines how antibiotics block specific proteins acting in these essential bacterial processes and how the molecular structure of the small-molecule drugs enables their antibiotic activity. Section III explores the development of bacterial resistance to antibiotics. The fourth section addresses the molecular logic of antibiotic biosynthesis, starting with regulatory networks that control gene transcription of secondary metabolites in streptomycetes.