General description
In almost all publications, the valuable information provided is almost always based on successful organic reactions. However, a chemist's life is not that easy. Trial and error is still one of the most commonly used methods. Thus it would be useful to have access to those syntheses that do not work, since they also provide important results of great importance for further synthesis. This book fills just such a gap. Using major total syntheses, the authors explain a variety of problems and recommend ways out of such dilemmas: Problems at the start and end of a synthesis, difficult and unexpected reactivities of functional groups, problems due to steric properties and much more. The result is a wealth of information for any organic chemist and an essential tool for successful total synthesis.
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