Applying Genomic and Proteomic Microarray Technology in Drug Discovery 

0-84931469-0

978-0-84931469-8

R. Matson, CRC Press, 2005, 243 pp., hard cover

QUANTITATIVE BIOLOGY: THE "OMICS" ERA
Introduction
Microarray Format
General Utility
The Omic Era
Role of Gene Expression Microarrays in Drug Discovery
Proteomics Today: The Great Challenge
Potential Role for Protein Microarrays in Drug Discovery
Critical Issues with Protein Microarrays
Future medicine: Pharmacoproteomics or pharmacogenomics?
References
COMMERCIAL MICROARRAYS
Introduction
In situ arrays
Ex situ or spotted arrays
3D and 4D chips
Flow-Through biochips note: flow-through is a general term when applied here, remove TM. This should have also been corrected in the book proofs.
Electronic biochips
Future opportunities
References
SUPPORTS AND SURFACE CHEMISTRIES
Introduction
Substrates
Summary
References
ARRAYING PROCESSES
Introduction
Creating spotted microarrays
Printing parameters
Protocols for printing nucleic acids
Protocols for printing proteins
References
GENE EXPRESSION: MICROARRAY-BASED APPLICATIONS
Introduction
Applications demonstrating DNA microarray utility
Biomedical research applications
References
PROTEIN MICROARRAY APPLICATIONS
Introduction
Spot theory
Applications demonstrating protein microarray utility
Measuring microarray performance
Other microarray formats useful for proteomic applications
References
Index