G Protein Coupled Receptors Handbook 

1-58829365-3

978-1-58829365-7

L. Devi, Humana Press, 2005, 424 pp., hard cover

PART I. GPCRs: Structure and Function
Structure–Function Relationships in G Protein-Coupled Receptors: Ligand Binding and Receptor Activation
Molecular Mechanisms Involved in the Activation of Rhodopsin-Like Seven-Transmembrane Receptors
GPCR Folding and Maturation: The Effect of Pharmacological Chaperones
Regulated Membrane Trafficking and Proteolysis of GPCRs

PART II. GPCR Activity and Its Regulators
Heterotrimeric G Proteins and Their Effector Pathways
RGS Proteins: Orchestration of Multiple Signaling Pathways
G Protein-Coupled Receptor Kinases
Regulators of GPCR Activity: The Arrestins
GPCR Interacting Proteins: Classes, Assembly, and Functions

PART III. GPCR Dimerization/Oligomerization
Biophysical and Biochemical Methods to Study GPCR Oligomerization
Oligomerization Domains of G Protein-Coupled Receptors: Insights Into the Structural Basis of GPCR Association
Functional Complementation and the Analysis of GPCR Dimerization
The Role of Oligomerization in G Protein-Coupled Receptor Maturation
Receptor Oligomerization and Trafficking
Modulation of Receptor Pharmacology by G Protein-Coupled Receptor Dimerization

PART IV. Recent Developments in Drug Discovery
Role of Heteromeric GPCR Interactions in Pain/Analgesia
Conformational Plasticity of GPCR Binding Sites: Structural Basis for Evolutionary Diversity in Ligand Recognition
De-Orphanizing GPCRs and Drug Development

Index