| Z705187 Sigma |
Adrenergic Receptors in the 21st Century |
General description
An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
Table of Contents
PART I. HISTORICAL PERSPECTIVES
1. Adrenergic Receptors: Historical Perspectives From the 20th Century
PART II. STRUCTURE-FUNCTION
2. Ligand Binding, Activation and Agonist Trafficking
3. New Signal Transduction Paradigms
4. Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors
5. Adrenergic Receptors in Clinical Medicine
PART II. IMAGING ADRENERGIC RECEPTORS AND THEIR FUNCTION
6. Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors
7. Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent Tagged Receptors
PART IV. GENETICALLY ALTERED MOUSE MODELS
8. The α1-Adrenergic Receptors: Lessons From Knockouts
9. The α2-Adrenerger Receptors: Lessons From Knockouts
10. The β-Adrenergic Receptors: Lessons From Knockouts
11. Lessons From Overexpressed Mouse Models
12. Adrenergic Receptor Signaling Components in Gene Therapy
PART V. PHARMACOGENOMICS
13. Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms
14. Microarray Analysis of Novel Adrenergic Receptor Functions
PART VI. SUMMARY AND FUTURE ENDEAVORS
15. Summary and Future Endeavors
Index
1. Adrenergic Receptors: Historical Perspectives From the 20th Century
PART II. STRUCTURE-FUNCTION
2. Ligand Binding, Activation and Agonist Trafficking
3. New Signal Transduction Paradigms
4. Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors
5. Adrenergic Receptors in Clinical Medicine
PART II. IMAGING ADRENERGIC RECEPTORS AND THEIR FUNCTION
6. Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors
7. Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent Tagged Receptors
PART IV. GENETICALLY ALTERED MOUSE MODELS
8. The α1-Adrenergic Receptors: Lessons From Knockouts
9. The α2-Adrenerger Receptors: Lessons From Knockouts
10. The β-Adrenergic Receptors: Lessons From Knockouts
11. Lessons From Overexpressed Mouse Models
12. Adrenergic Receptor Signaling Components in Gene Therapy
PART V. PHARMACOGENOMICS
13. Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms
14. Microarray Analysis of Novel Adrenergic Receptor Functions
PART VI. SUMMARY AND FUTURE ENDEAVORS
15. Summary and Future Endeavors
Index
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