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General description
The importance of epigenetics regulation of gene expression, particularly in higher organisms is now clear and the 2004 Cold Spring Harbor Annual Symposium provided many new examples as well as insights into underlying mechanisms. The resulting volume - with over 60 papers from experts across the field - covers various aspects of nuclear organization and dynamics; genomic imprinting, chromosomal inactivation, and other examples of gene silencing; the histone and DNA modifications associated with these conditions; and the roles of RNA and protein regulators in establishing and maintaining these states.
Table of Contents
Introduction
Nuclear reprogramming, chromosome inactivation, and imprinting Samll RNAs I DNA Methylation-mechanism and regulation Position effect and nuclear organization Chromatin inheritance and assembly Epigenetic regulation and gene expression Histone modification Epigenetics twists Small RNAs II Epigenetics and disease Summary by D. Gottschling
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