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Epigenetics

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General description

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals..

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Identifiers

ISBN-13

978-0-87969-724-2

Properties

publication info

C. Allis, et al., ed., Cold Spring Harbor Laboratory Press, 2007, 502 pp., hard cover

Table of Contents

1. Epigenetics: From Phenomenon to Field
2. A Brief History of Epigenetics
3. Overview and Concepts
4. Epigenetics in Saccharomyces cerevisiae
5. Position Effect Variegation, Heterochro-matin Formation, and Gene Silencing in Drosophila
6. Fungal Models for Epigenetic Research: Schizosaccharomyces pombe and Neurospora crassa
7. Epigenetics of Ciliates
8. RNAi and Heterochromatin Assembly
9. Epigenetic Regulation in Plants
10. Chromatin Modifications and Their Mechanism of Action
11. Transcriptional Silencing by Polycomb Group Proteins
12. Transcriptional Regulation by Trithorax Group Proteins
13. Histone Variants and Epigenetics
14. Epigenetic Regulation of Chromosome Inheritance
15. Epigenetic Regulation of the X Chromosomes in C. elegans
16. Dosage Compensation in Drosophila
17. Dosage Compensation in Mammals
18. DNA Methylation in Mammals
19. Genomic Imprinting in Mammals
20. Germ Line and Pluripotent Stem Cells
21. Epigenetic Control of Lymphopoiesis
22. Nuclear Transplantation and the Reprogramming of the Genome
23. Epigenetics and Human Disease
24. Epigenetic Determinants of Cancer
Appendices
Index