IRS1 insulin receptor substrate 1

Gene and Product Information
IRS1	insulin receptor substrate 1

Properties

Official Symbol

IRS1

Species

Homo sapiens

Entrez Gene ID

3667

Alternate Symbol

IRS1; HIRS-1

Refseq ID(s)

NM_005544

Accession No.(s)

BC053895; NM_005544; S62539

Protein ID(s)

NP_005535

Homolog(s)

Irs1(Mouse); Irs1(Rat)

Function(s)

protein binding; signal transducer

Pathway(s)

Akt Signaling; IGF1R Signaling; Insulin Receptor Pathway; JNK Pathway; PI3K Signaling; more...

Available Product(s)

siRNA, Antibodies, shRNA

Useful External Links

NCBI Gene Info.

Compendia Bioscience

Human Protein Reference Database

PubMed

Cytoscape

Gene Expression Tools

Related Products

Antibodies

Product #	Description	Species Reactivity
I7153	Anti-Insulin Receptor Substrate 1 (IRS-1) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	human, rat, mouse
I6031	Anti-phospho-Insulin Receptor Substrate 1 (pSer⁶¹⁶) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	mouse, human, rat
I2533	Anti-phospho-Insulin Receptor Substrate-1 (pSer³¹²) antibody produced in rabbit affinity isolated antibody, buffered aqueous glycerol solution	human
I1658	Anti-phospho-Insulin Receptor Substrate-1 (pTyr¹¹⁷⁹) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	human, rat, mouse
I2283	Anti-phospho-Insulin Receptor Substrate-1 (pTyr¹²²⁹) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	human
I2408	Anti-phospho-Insulin Receptor Substrate-1 (pTyr⁸⁹⁶) antibody produced in rabbit affinity isolated antibody, buffered aqueous glycerol solution	human, rat (predicted), mouse (predicted)
I1533	Anti-phospho-Insulin Receptor Substrate-1 (pTyr⁹⁴¹) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	human, human
I2658	Anti-phospho-Insulin Receptor Substrate-1 (pTyr^r612) antibody produced in rabbit affinity isolated antibody, buffered aqueous glycerol solution	human

MISSION shRNA

Type	Description
SHGLY-NM_005544	MISSION^® shRNA Bacterial Glycerol Stock
SHVRS-NM_005544	MISSION^® shRNA Lentiviral Transduction Particles
SHDNA-NM_005544	MISSION^® shRNA Plasmid DNA

siRNA

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siRNA ID	RefSeq ID	Approx. siRNA Start	siRNA Type	Ranking
SASI_Hs01_00226939	NM_005544	2286	MISSION® siRNA	1
SASI_Hs01_00226940	NM_005544	1213	MISSION® siRNA	2
SASI_Hs01_00226941	NM_005544	3933	MISSION® siRNA	3
SASI_Hs01_00226942	NM_005544	1334	MISSION® siRNA	4
SASI_Hs01_00226943	NM_005544	1068	MISSION® siRNA	5
SASI_Hs01_00226944	NM_005544	3391	MISSION® siRNA	6
SASI_Hs01_00226945	NM_005544	1091	MISSION® siRNA	7
SASI_Hs01_00226946	NM_005544	2247	MISSION® siRNA	8
SASI_Hs01_00226947	NM_005544	3398	MISSION® siRNA	9
SASI_Hs01_00226948	NM_005544	2216	MISSION® siRNA	10

Sigma's MISSION^® siRNA have been designed using a world-class siRNA design algorithm licensed from Rosetta Inpharmatics, a leader in advanced siRNA research. Critical rules incorporated into the best-in-class Rosetta siRNA design algorithm lead to siRNA of increased target specificity and knockdown for low abundance messages.

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