KDR kinase insert domain receptor (a type III receptor tyrosine kinase)

Activation of PKA through GPCR; Akt Signaling; CREB Pathway; ERK Signaling; GPCR Pathway; GSK3 Signaling; IP3 Pathway; Intracellular Calcium Signaling; JNK Pathway; MAPK Family Pathway; Molecular Mechanisms of Cancer; P2Y Receptor Signaling; PAK Pathway; PI3K Signaling; PPAR Pathway; PTEN Pathway; Paxillin Interactions; Ras Pathway; VEGF Pathway; cAMP Pathway; eIF2 Pathway; p38 Signaling; p70S6K Signaling; 14-3-3 Induced Intracellular Signaling; Actin Nucleation and Branching; Actin Nucleation by ARP-WASP Complex; Actin-Based Motility by Rho Family GTPases; Activation of cAMP-Dependent PKA; Apoptotic Pathways in Synovial Fibroblasts; Cellular Apoptosis Pathway; Endothelin-1 Signaling Pathway; Estrogen Pathway; Inhibition of Angiogenesis by TSP1; Mitochondrial Apoptosis; NF-KappaB Family Pathway; NFAT in Immune Response; Nuclear Receptor Activation by Vitamin-A; Renin-Angiotensin Pathway; RhoGDI Pathway; TGF-Beta Pathway; Telomerase Components in Cell Signaling; VEGF and S-1P Signaling; Yersinia Infection; eNOS Signaling;
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Gene and Product Information
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)

Properties

Official Symbol

KDR

Species

Homo sapiens

Entrez Gene ID

3791

Alternate Symbol

KDR; CD309; FLK1; VEGFR; VEGFR2

Refseq ID(s)

NM_002253

Other Designations

vascular endothelial growth factor receptor 2

Accession No.(s)

AB209901; AF035121; AF063658; BC131822; CR606055; more...

Protein ID(s)

NP_002244

Homolog(s)

Kdr(Mouse)

Function(s)

growth factor/ligand/cytokine/chemokine receptor; signal transducer; transferase

Pathway(s)

Activation of PKA through GPCR; Akt Signaling; CREB Pathway; ERK Signaling; GPCR Pathway; more...

Available Product(s)

siRNA, Antibodies, Small Molecule - Inhibitor, Proteins, MISSION shRNA Panels, shRNA, MISSION siRNA Panels

Useful External Links

NCBI Gene Info.

Compendia Bioscience

Human Protein Reference Database

PubMed

Cytoscape

Gene Expression Tools

Related Products

Antibodies

Product #	Description	Species Reactivity
V5389	Anti-phospho-VEGF R2 (pTyr¹⁰⁵⁴) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	human, mouse, rat
V5014	Anti-phospho-VEGF R2 (pTyr¹⁰⁵⁴/pTyr¹⁰⁵⁹) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	human, mouse, rat
V5264	Anti-phospho-VEGF R2 (pTyr¹²¹⁴) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	human, mouse, rat
V5139	Anti-phospho-VEGF R2 (pTyr⁹⁵¹) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	human
WH0003791M1	Monoclonal Anti-KDR antibody produced in mouse clone 2A2, purified immunoglobulin, buffered aqueous solution	human
V3003	Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 (KDR) antibody produced in mouse clone 260.4, KDR-2, ascites fluid	human
B0555	Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 (KDR)−Biotin antibody produced in mouse clone 260.4, KDR-2, purified immunoglobulin, buffered aqueous solution	human
V9134	Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse clone KDR-1, ascites fluid	human

Proteins

Product #	Description
K2643	KDR (789-end), active, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Small Molecule - Inhibitor

Product #	Description
C8863	7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine ≥98% (HPLC)
P2499	PD 173074 ≥98% (HPLC), solid
S8442	SU 5416 ≥98% (HPLC)
594687	α-Sexithiophene

MISSION shRNA

Type	Description
SHGLY-NM_002253	MISSION^® shRNA Bacterial Glycerol Stock
SHVRS-NM_002253	MISSION^® shRNA Lentiviral Transduction Particles
SHDNA-NM_002253	MISSION^® shRNA Plasmid DNA

MISSION shRNA Panels

Product #	Description
SHX001	MISSION^® LentiExpress^™ Human Kinases