BTK Bruton agammaglobulinemia tyrosine kinase

Akt Signaling; IP3 Pathway; JNK Pathway; MAPK Family Pathway; PAK Pathway; PI3K Signaling; SOCS Pathway; STAT3 Pathway; Toll-Like Receptors Pathway; p38 Signaling; Airway Pathology in COPD; BCR Pathway; Bacterial Meningitis; Cellular Immune Responses to HBV; Fas Signaling; Fc-EpsilonRI Pathway; Fc-Gamma-RIIB Signaling in B-Cells; Fc-GammaR Pathway; Glucocorticoid Receptor Signaling; IL-6 Pathway; MIF Mediated Glucocorticoid Regulation; MIF Regulation of Innate Immune Cells; NFAT Signaling and Lymphocyte Interactions; NFAT in Immune Response; PEDF Induced Signaling; PGC1Alpha Pathway; PI3K Signaling in B-Lymphocyte; Regulation of eIF4 and p70S6K; TGF-Beta Pathway; Tec Kinases Signaling; all-trans-Retinoic Acid Signaling in Brain;
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Gene and Product Information
BTK	Bruton agammaglobulinemia tyrosine kinase

Properties

Official Symbol

BTK

Species

Homo sapiens

Entrez Gene ID

695

Alternate Symbol

BTK; AGMX1; AT; ATK; BPK; IMD1; MGC126261; MGC126262; PSCTK1; XLA

Other Designations

Bruton's tyrosine kinase; OTTHUMP00000063593; dominant-negative kinase-deficient Brutons tyrosine kinase; tyrosine-protein kinase BTK

Refseq ID(s)

NM_000061

Accession No.(s)

AF153364; AF153755; AF153756; AF153757; AF153758; more...

Protein ID(s)

NP_000052

Homolog(s)

Btk(Mouse); Btk(Rat)

Function(s)

protein binding; protein kinase; transferase

Pathway(s)

Akt Signaling; IP3 Pathway; JNK Pathway; MAPK Family Pathway; PAK Pathway; more...

Available Product(s)

siRNA, Antibody Arrays, Antibodies, Small Molecule - Inhibitor, MISSION shRNA Panels, shRNA, MISSION siRNA Panels

Useful External Links

NCBI Gene Info.

Compendia Bioscience

Human Protein Reference Database

PubMed

Cytoscape

Gene Expression Tools

Related Products

Antibodies

Product #	Description	Species Reactivity
B3187	Anti-BTK (270-284) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	human
B3312	Anti-BTK (594-608) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	human
HPA001198	Anti-BTK antibody produced in rabbit Ab1, Prestige Antibodies^™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	human
HPA002028	Anti-BTK antibody produced in rabbit Ab2, Prestige Antibodies^™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	human
B0811	Anti-BTK, C-Terminal antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	human
B0686	Anti-BTK, N-Terminal antibody produced in rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous solution	human

Small Molecule - Inhibitor

Product #	Description
L8789	LFM-A13 >98% (HPLC), powder

MISSION shRNA

Type	Description
SHGLY-NM_000061	MISSION^® shRNA Bacterial Glycerol Stock
SHVRS-NM_000061	MISSION^® shRNA Lentiviral Transduction Particles
SHDNA-NM_000061	MISSION^® shRNA Plasmid DNA

MISSION shRNA Panels

Product #	Description
SHX001	MISSION^® LentiExpress^™ Human Kinases
SH1911	MISSION^® shRNA Human Gene Family Set, Bacterial Glycerol Stock Apoptosis Pathway
SH2911	MISSION^® shRNA Human Gene Family Set, Bacterial Glycerol Stock B-Cell Activation
SH0111	MISSION^® shRNA Human Gene Family Set, Bacterial Glycerol Stock Kinases
SH2411	MISSION^® shRNA Human Gene Family Set, Bacterial Glycerol Stock p53 Pathway
SH1921	MISSION^® shRNA Human Gene Family Set, DNA Apoptosis Pathway
SH2921	MISSION^® shRNA Human Gene Family Set, DNA B-Cell Activation
SH0121	MISSION^® shRNA Human Gene Family Set, DNA Kinases
SH2421