TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)

Akt Signaling; ERK Signaling; GPCR Pathway; GSK3 Signaling; Intracellular Calcium Signaling; JNK Pathway; Molecular Mechanisms of Cancer; P2Y Receptor Signaling; PI3K Signaling; Paxillin Interactions; Ras Pathway; STAT3 Pathway; p38 Signaling; 14-3-3 Induced Intracellular Signaling; Actin Nucleation and Branching; Actin Nucleation by ARP-WASP Complex; Activation of cAMP-Dependent PKA; Angiopoietin-TIE2 Signaling; Endothelin-1 Signaling Pathway; Estrogen Pathway; NFAT in Immune Response; Tec Kinases Signaling; Yersinia Infection; eNOS Signaling;
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Gene and Product Information
TEK	TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)

Properties

Official Symbol

TEK

Species

Homo sapiens

Entrez Gene ID

7010

Alternate Symbol

TEK; CD202B; TIE-2; TIE2; VMCM; VMCM1

Other Designations

TEK tyrosine kinase, endothelial

Refseq ID(s)

NM_000459

Accession No.(s)

AB086825; AB208796; AW020953; BC035514; CA392256; more...

Protein ID(s)

NP_000450

Homolog(s)

Tek(Mouse); Tek(Rat)

Function(s)

protein kinase; signal transducer; transferase

Pathway(s)

Akt Signaling; ERK Signaling; GPCR Pathway; GSK3 Signaling; Intracellular Calcium Signaling; more...

Replaces Gene ID(s)

7437

Available Product(s)

siRNA, Antibodies, Small Molecule - Inhibitor, Proteins, MISSION shRNA Panels, shRNA, MISSION siRNA Panels

Useful External Links

NCBI Gene Info.

Compendia Bioscience

Human Protein Reference Database

PubMed

Cytoscape

Gene Expression Tools

Related Products

Antibodies

Product #	Description	Species Reactivity
HPA011738	Anti-TEK antibody produced in rabbit Prestige Antibodies^™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	human
T3192	Anti-Tie 2 antibody produced in goat affinity isolated antibody, lyophilized powder	human
WH0007010M2	Monoclonal Anti-TEK antibody produced in mouse clone 3F8, purified immunoglobulin, buffered aqueous solution	human

Proteins

Product #	Description
T1691	Tie-2/Fc Chimera human ≥95% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder, cell culture tested

Small Molecule - Inhibitor

Product #	Description
C8863	7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine ≥98% (HPLC)

MISSION shRNA

Type	Description
SHGLY-NM_000459	MISSION^® shRNA Bacterial Glycerol Stock
SHVRS-NM_000459	MISSION^® shRNA Lentiviral Transduction Particles
SHDNA-NM_000459	MISSION^® shRNA Plasmid DNA

MISSION shRNA Panels

Product #	Description
SHX001	MISSION^® LentiExpress^™ Human Kinases
SH2511	MISSION^® shRNA Human Gene Family Set, Bacterial Glycerol Stock Extracellular Matrix Genes
SH0111	MISSION^® shRNA Human Gene Family Set, Bacterial Glycerol Stock Kinases
SH2521	MISSION^® shRNA Human Gene Family Set, DNA Extracellular Matrix Genes
SH0121	MISSION^® shRNA Human Gene Family Set, DNA Kinases
SH2531	MISSION^® shRNA Human Gene Family Set, Lentiviral Particles Extracellular Matrix Genes
SH0131	MISSION^® shRNA Human Gene Family Set, Lentiviral Particles Kinases

MISSION siRNA Panels

Product #	Description
SI00100	MISSION^® siRNA Human Druggable Genome Library 6650 targets