CASP8 caspase 8, apoptosis-related cysteine peptidase

Apoptosis through Death Receptors; Caspase Cascade; Ceramide Pathway; Molecular Mechanisms of Cancer; PAK Pathway; p53 Signaling; 14-3-3 Induced Apoptosis; Apoptotic Pathways in Synovial Fibroblasts; Bacterial Meningitis; CTL Mediated Apoptosis; Cellular Apoptosis Pathway; DR3 Signaling; Endothelin-1 Signaling Pathway; Fas Signaling; GITR Pathway; Granzyme Pathway; Granzyme-B Pathway; Huntingtin Comparative Pathway; Huntington Disease Pathway; Mitochondrial Apoptosis; PEDF Induced Signaling; S-1P Stimulated Signaling; TNF Signaling; TNF Superfamily Pathway; TNF-Induced Apoptosis Implicating Sphingolipids; TNFR1 Pathway; TRAF Pathway; TRAIL Pathway; TWEAK Pathway; Tumoricidal Effects of Hepatic NK Cells; UVA-Induced MAPK Signaling; Yersinia Infection; all-trans-Retinoic Acid Mediated Apoptosis; c-Myc and Apoptosis; eNOS Signaling;
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Gene and Product Information
CASP8	caspase 8, apoptosis-related cysteine peptidase

Properties

Official Symbol

CASP8

Species

Homo sapiens

Entrez Gene ID

841

Alternate Symbol

CASP8; ALPS2B; CAP4; FLICE; MACH; MCH5; MGC78473

Refseq ID(s)

NM_001080124; NM_001080125; NM_001228; NM_033355; NM_033356; NM_033358

Other Designations

FADD-homologous ICE/CED-3-like protease; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; Mch5 isoform alpha; caspase 8; caspase 8, apoptosis-related cysteine protease; cysteine protease; procaspase-8

Accession No.(s)

AA312258; AF009620; AF380342; AF422926; AF422927; more...

Protein ID(s)

NP_001073593; NP_001073594; NP_001219; NP_203519; NP_203520; NP_203522

Homolog(s)

Casp8(Mouse); Casp8(Rat)

Function(s)

apoptosis; protease; signal transducer

Pathway(s)

Apoptosis through Death Receptors; Caspase Cascade; Ceramide Pathway; Molecular Mechanisms of Cancer; PAK Pathway; more...

Available Product(s)

siRNA, Antibody Arrays, Antibodies, Small Molecule - Inhibitor, Proteins, MISSION shRNA Panels, shRNA, MISSION siRNA Panels

Useful External Links

NCBI Gene Info.

Compendia Bioscience

Human Protein Reference Database

PubMed

Cytoscape

Gene Expression Tools

Related Products

Antibodies

Product #	Description	Species Reactivity
HPA005688	Anti-CASP8 antibody produced in rabbit Ab1, Prestige Antibodies^™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	human
HPA008936	Anti-CASP8 antibody produced in rabbit Ab2, Prestige Antibodies^™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	human
HPA001302	Anti-CASP8 antibody produced in rabbit Ab3, Prestige Antibodies^™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	human
C2976	Anti-Caspase 8 (GD-13) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	human
C3101	Anti-Caspase 8 (SK-16) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	human
C7849	Anti-pro-Caspase 8 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	human
C4106	Monoclonal Anti-Caspase 8 antibody produced in mouse ~2 mg/mL, clone CAS8, purified immunoglobulin, buffered aqueous solution	human

Proteins

Product #	Description
C1099	Caspase 8 human ≥90% (SDS-PAGE), recombinant, expressed in Escherichia coli (C-terminal histidine tagged), buffered aqueous solution, ≥1,000 units/mg protein
C8357	Caspase Combo III, Type 6, 8, 9 and 10 human >90% (SDS-PAGE), recombinant, expressed in Escherichia coli, lyophilized powder

Small Molecule - Inhibitor

Product #	Description
A0835	N-Acetyl-Asp-Glu-Val-Asp-al ≥95%, powder

MISSION shRNA

Type