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Bradykinins

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Biochem/physiol Actions
Product #
Bradykinin acetate powder, ≥98% (HPLC) Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.
 B3259
Nα-Adamantaneacetyl-D-Arg-[Hyp3, Thi5,8, D-Phe7]-Bradykinin ≥97% (HPLC) A highly potent antagonist at bradykinin B2 receptors with no agonist activity.
 B6029
D-Arg-[Hyp3, D-Phe7, Leu8]-Bradykinin ≥97% (HPLC) Short-acting competitive antagonist that discriminates between B2a and B2b bradykinin receptors; weak B1 bradykinin receptor antagonist.
 B4916
D-Arg-[Hyp3, Thi5,8, D-Phe7]-Bradykinin ≥97% (HPLC) B2 bradykinin receptor antagonist.
 B1650
des-Arg9-[Leu8]-Bradykinin acetate salt ≥97% (HPLC) Bradykinin receptor antagonist.
 B6769
des-Pro2-Bradykinin ≥97% (HPLC) Potentiates activity on bradykinin-induced contraction of guinea pig ileum and hypertension in rats
 B2026
[des-Pro3, Ala2,6]-Bradykinin ≥97% (HPLC) B4791
[Hyp3]-Bradykinin ≥97% (HPLC) B2 bradykinin receptor agonist.
 B7775
[Lys-des-Arg9]-Bradykinin ≥95% (HPLC) [Des-Arg10]-kallidin is a bradykinin B1 receptor agonist. It strongly upregulates the B1 receptor and is blocked by a specific protein kinase C inhibitor. The upregulation is correlated with the induction of transcription factor nuclear factor κB (NF-κB).
 B1542
Lys-(des-Arg9, Leu8)-Bradykinin trifluoroacetate salt ≥95% B1 bradykinin receptor antagonist.
 B6929
7-Methoxycoumarin-4-acetyl [Ala7-(2,4-Dinitrophenyl)Lys9]-Bradykinin trifluoroacetate salt >94% (HPLC) B5181
Met-Lys-[Ser2, Arg3, Pro5, Arg8]-Bradykinin ≥97% (HPLC) M0421
Bradykinin Fragment 1-5 ≥97% (HPLC) The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.
 B1401
Bradykinin Fragment 1-7 ≥97% (HPLC) B1651
Bradykinin Fragment 1-8 acetate hydrate ≥97% (HPLC) Selective B1 bradykinin receptor agonist.
 B4397
Bradykinin Fragment 2-9 ≥97% (HPLC) The des-arginine-1 bradykinin (BK) peptide (2-9) has no detectable contractile activity, inhibits ACE (angiotensin converting enzyme) and potentiates BK.
 B1901
Bradykinin potentiator B ≥97% (TLC) B0507
Bradyzide di(trifluoroacetate) salt hydrate ≥98% Potent, orally active, non-peptide B2 bradykinin receptor antagonist.
 B1680
HOE 140 ≥94% Selective B2 bradykinin receptor antagonist.
 H157
[des-Arg10]-HOE 140 synthetic, >98%, powder Potent B1 bradykinin receptor antagonist.
 H158
Kininogen, low molecular weight from human plasma >95% (SDS-PAGE), lyophilized powder LMW kininogen is a major extracellular cysteine proteinase inhibitor. Tissue kallikrein releases bradykinin, a potent bronchoconstrictor and vasoactive agent, from both HMW and LMY kininogen.
 K3628
Tyr-Bradykinin acetate hydrate ≥97% (HPLC) B4764

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