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Biochemistry books

Life Science and Chemistry books

Our Biochemistry books span a wide range of titles from adenovirus to metabolomics to zebrafish.

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A7226 Adenoviral Vectors for Gene Therapy This book provides detailed, comprehensive coverage of the gene delivery vehicles based on the adenovirus, which are important tools for gene therapy. These new therapeutic agents have great potential in the treatment of disease. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope provides a complete understanding of the development and use of adenoviral vectors.
A2594 Adenovirus: Methods and Protocols A cutting-edge collection of readily reproducible methods for conducting research with adenoviruses, the premier and most widely used model in cell and molecular biology. The methods range from how to grow and titer adenoviruses and how to construct specific alterations in the adenovirus genome, to how to measure apoptosis induced by cells of the immune system, cytokines, and intrinsic apoptosis effectors. In addition, there are methods to study transcription and splicing with in vitro systems and for the adenovirus-mediated transformation of cells to a malignant state.
A9721 Adhesion Molecule Factsbook, 2nd ed. Second Edition is completely updated, and expanded to reflect new advances. It contains over 80 entries on all currently cloned and characterized cell adhesion molecules, including the families of integrins, cadherins, selectins, members of the immunoglobulin superfamily, and other relevant receptors. It provides information on amino acid sequence of the most commonly studied organisms; gene organization and chromosomal location; alternative nomenclature; biological function; tissue distribution; disease association; database accession numbers.
A6347 Amino Acid Analysis Protocols This book is a collection of classic and cutting-edge techniques for answering specific biological questions about amino acids. Methods include those based on HPLC or gas chromatography separation and analysis after precolumn derivatization. New techniques based on capillary electrophoresis separation, high performance anion exchange chromatography, and mass spectrometry are presented. Each method is described in detail to ensure success and emphasizes sample preparation, particularly collection and storage of bodily fluids.
A6222 Angiotensin Protocols The renin-angiotensin system has been in the spotlight fo rmore than 100 years because of its vital role in blood pressure regulation, ion and fluid homeostasis, and tissue growth and remodeling. This book describes in step-by-step detail all the major molecular, biochemical, and functional techniques used in probing the renin-angiotensin system. These range from the use of embryonic gene targeting to create of mutant strains, to the functional investigation of components of the renin-angiotensin system. This comprehensive text translates expert knowledge into readily reproducible methods that enable all biomedical investigators successfully to explore the role of angiotensin in hypertension, congestive heart failure, chronic renal failure and stroke.
A9221 Antibiotic Resistance: Methods and Protocols This book describes a series of molecular and physical methods designed to study the growing problem of antibiotic resistance, as well as facilitate new antibiotic research programs for its effective redress. Techniques range widely from those that provide rapid diagnosis via DNA amplification and phage display, to those for plotting the transmission of resistant organisms and investigating their epidemiology. Methods are readily adaptable to a wide range of resistant bacterial organisms. Techniques are provided for basic biology of antimicrobial resistance, and for developing new diagnostic tools.
Z702986 Antibiotics: Actions, Origins, Resistance This text offers a comprehensive account of the structural classes of antibiotics. While most of the attention is on natural products, synthetic chemicals with antibiotic activity are also discussed. The book contains a section that examines how antibiotics block specific proteins acting in these essential bacterial processes and how the molecular structure of the small-molecule drugs enables their antibiotic activity. Section III explores the development of bacterial resistance to antibiotics. The fourth section addresses the molecular logic of antibiotic biosynthesis, starting with regulatory networks that control gene transcription of secondary metabolites in streptomycetes.
A6346 Antigen Processing and Presentation Protocols Drawing on expertise, investigators describe step-by-step methods designed to question how major histocompatibility complex-binding peptides are generated, to test how peptides are delivered to MHC molecules, to analyze MHC peptide-binding patterns, and to assay the T-cell response to the MHC/peptide complex. Emphasis is given those technical steps critical for experimental success that are often omitted from methods published in the primary literature.
Z718165 Arabidopsis The cruciferous weed Arabidopsis thialiana has become a model system for the study of an unusually wide variety of aspects of plant biology. As a result, nearly all aspects of Arabidopsis biology are now under investigation, more scientists are involved, and plant science as a whole has been invigorated.
This book is the first comprehensive account of what is known about the organism. The information is presented in the context of plant biology in general, with the properties of Arabidopsis mutants and the insights derived from their analysis as a unifying theme. The book's scope includes genetics, growth and development, biochemistry, physiology, and responses to pathogens and environmental stress.
This unique volume, in the classic tradition of the Cold Spring Harbor Monograph Series, is a landmark in plant science, essential reading for investigators at graduate student level and beyond, and a work of reference that will serve the field for years to come.
Z705772 Arabidopsis Protocols 2nd ed. This collection of reproducible Arabidopsis protocols has been updated to reflect recent advances in plant biology, the completion of the Arabidopsis genome sequence—essential for studying plant function, and the development of whole systems approaches that allow global analysis of gene expression and protein and metabolite dynamics. The authors have included nearly all techniques developed in Arabidopsis, others recently adapted from the traditional work in crop species, and the most recent ones using Arabidopsis as a model system. Highlights include the most recent methods—transcriptomics, proteomics, and metabolomics—and their novel applications (phosphoproteomics, DNA microarray-based genotyping, high throughput metabolite profiling, and single-cell RNA).
Z705055 Artificial Enzymes This first book on this fascinating topic is edited by one of today's most famous and internationally respected organic chemists, who has been studying enzyme mimics and artificial enzymes for more than four decades. Ronald Breslow has brought together leading scientists in this expanding area for an in-depth survey of the synthesis and design of enzyme-like catalysts.
Z702625 Bio conjugation Protocols: Strategies and Methods Experts update the classic bioconjugation methods and introduce techniques that go beyond pure biomedical applications to include elements from organic synthesis, molecular biology, and materials science. These methods cover the preparation of protein conjugates using covalent and noncovalent conjugation, the synthesis of nucleic acid conjugates using a variety of labeling techniques, and approaches to semisynthetic conjugates of proteins. Additional chapters address on-chip synthesis to generate microarrays for the high-throughput analysis of RNA and DNA.
B9911 Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology This truly unique road map to modern biochemistry is an atlas of multi-step reactions in biological systems. The book graphically represents this network of reactions with a series of chemical formulas along with two-dimensional spatial arrangements demonstrating each molecule's cellular, organic, and structural aspects. It is an encyclopedic, comprehensive, and clearly organized reference for any biochemist.
Z731005 Biochemistry 6th ed. In the new edition of Biochemistry, instructors will see the all the hallmark features that made this a consistent bestseller for the undergraduate biochemistry course: exceptional clarity and concision, a more biological focus, cutting-edge content, and an elegant, uncluttered design. Accomplished in both the classroom and the laboratory, coauthors Jeremy Berg and John Tymoczko draw on the field’s dynamic research to illustrate its fundamental ideas.
Z704644 Biochemistry and Molecular Biology 3rd ed. An understanding of biochemistry and molecular cell biology opens the door to an understanding of life itself. Biochemistry and Molecular Biology introduces this subject to the widest range of students, providing insights into this fascinating area. The new edition takes students from the fundamentals of cell biology and biochemistry to the latest advances in genomics and proteomics. Maintaining the clear, accessible approach of previous editions, this volume is enriched by carefully layered explanations and vivid illustrations throughout.
B6308 Biochemistry of Cell Signalling This will serve as a reliable map through the maze of cell signaling pathways and help the reader understand how malfunctions in these pathways can lead to disease. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. Part 2 describes the implementation of the signaling cascades focusing on the effect on gene transcription. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer.
Z701297 Biochemistry of Signal Transduction and Regulation, 3rd ed. This book has become the "gold standard" in the field of signal transduction and offers unmatched quality from the pen of a single author. The author succeeds in balancing comprehensive coverage with a clear and didactic style. The new edition is completely updated. 50% of the content has been rewritten to incorporate recent findings, and many illustrations have been redrawn and are now presented in full color.
Z700444 Biochemistry:The Chemical Reactions of Living Cells, 2nd ed., Vol. 1 The most comprehensive textbook/reference ever to cover the chemical basis of life, the "Green Bible of Biochemistry" has been a well-respected contribution to the field for more than twenty years. The complex structures that make up cells are described in detail, along with the forces that hold them together, and the chemical reactions that allow for recognition, signaling and movement. There is ample information on the human body, its genome, and the action of muscles, eyes, and the brain. The complete set deals with the natural world, treating the metabolism of bacteria, toxins, antibiotics, specialized compounds made by plants, photosynthesis, luminescence of fireflies, among many other topics.
Z703559 Biocomputing: Computer Tools For Biologists BioComputing: Computer Tools for Biologists contains a selection of BioTechniques' best Biocomputing papers from 1996-2002 augmented with original author updates. This comprehensive collection provides researchers with simple programs and open source code that can be used as models to study, copy, and modify for developing new computer programs. It also contains useful tools and insights into how to design better queries and interpret results more carefully, thus making more effective use of websites such as BLAST and PubMed.
B5056 Bioinformatics Basics: Applications in Biological Science and Medicine Scientists use an extensive databank to access structural information on proteins and nucleic acids and a specialized form of software to analyze the hybridization pattern of DNA chips. The success of biotechnology and pharmaceutical industries has been a result of technical advancements in genomics, proteomics, and bioinformatics. This book describes the organization of public domain databases with a tutorial for the services described. It concentrates on three major database clusters and relevant software tools that are maintained in the US, Europe, and Japan.
Z700517 Bioinformatics for Dummies A practical introduction to bioinformatics-computer technologies that biochemical and pharmaceutical researchers use to analyze genetic and biological data * Shows how to do sophisticated bioinformatic analysis without learning UNIX first * Helps researchers choose the right bioinformatics tool, use it effectively, and interpret the results * Guides readers to the most helpful Web resources and freely available tools * Addresses common biological questions, problems, and projects, while also providing a UNIX/Linux overview and tips on using Perl * Companion Web site contains the data sets used in the book and useful related links
Z730386 Bioinformatics for Dummies 2nd ed. Explore the human genome and analyze DNA — without leaving your desktop! All it takes is the basics of molecular biology and the wealth of information in this friendly guide. You'll discover the online tools and useful tips you need to ask the right questions, analyze sequences, and compare results. It's a plain-English introduction to the field! Discover how to do biological research online; Use gene-centric databases; Visualize proteins in 3-D; Interpret and analyze sequences; Produce and publish results.
Z703591 Bioinformatics: A Guide to the Analysis of Genes and Proteins, 3rd ed. Using relevant biological examples, the book provides background on and strategies for using many of the most powerful and commonly used computational approaches for biological discovery. This new edition features new chapters on genomic databases, predictive methods using RNA sequences, sequence polymorphisms, protein structure prediction, intermolecular interactions, and proteomic approaches for protein identification. It contains detailed worked examples illustrating the use of the concepts presented. Special topic boxes and appendices highlighting experimental strategies and advanced concepts are included with annotated reference lists, comprehensive lists of relevant Web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics
B8308 Bioinformatics: From Genomes to Drugs, 2 Volume Set Bioinformatics promises to revolutionize the process of drug discovery and development. This book provides an application-oriented overview of this technology. In addition, the state-of-the-art in bioinformatics is evaluated from a global view by introducing real application scenarios such as genome projects that require the use of a whole set of bioinformatics tools. The knowledge on bioinformatics presented enables readers to go beyond a mere push-button approach to using bioinformatics software and interpreting the data generated, but also to assess the potential and limitations of today's bioinformatics software and future challenges.
Z730866 Bioinformatics: Methods Express The book provides the clear advice and explicit protocols that non-bioinformaticians need in order to understand what to do - and how to avoid common pitfalls. Each chapter guides you through the major databases and tools with worked examples - all accompanied by sample data files available online.Topics covered include:*data access, *sequence searches and alignments, *identification and annotation of features, *the transcriptome, *protein structure and function, *comparisons and phylogeny. This book is a comprehensive manual for all wet-bench scientists who need to use bioinformatics - from postgraduate student to principal investigator.
Z651923 Bioinformatics: Sequence and Genome Analysis, 2nd Edition As more species’ genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.
Z651931 Bioinformatics: Sequence and Genome Analysis, 2nd Edition As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. New features include chapter guides and explanatory information panels and glossary terms. New chapters cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book.
B8161 Bioinformatics: Sequence, Structure and Databanks, A Practical Approach Covers practical important topics in the analysis of protein sequences and structures. It compares amino acid sequences to structures comparing structures to each other, and presents searching information on entire protein families as well as searching with single sequences. It shows how to set up and use the SRS molecular biology database management system. There are chapters on multiple sequence alignment and protein secondary structure prediction.
Z269670 Biologically Active Peptides: Design, Synthesis, and Utilization Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.
Z730343 Biology of Cancer The Biology of Cancer synthesizes the findings of three decades of recent cancer research and proposes a conceptual framework from which to teach about these discoveries. It provides the necessary structure, organization, and content for a course on cancer biology for advanced undergraduates and beginning doctoral students. The book is comprehensive and offers many pedagogical features to assist teaching and learning. The text provides current information on topics such as tumor stem cells and recently introduced chemotherapeutics. State-of-the-art techniques are discussed throughout. Modern biomedical research is explored, helping readers to hone their analytical abilities and to assimilate and think clearly about complex biological processes.
B4556 Biology of Phosphoinositides This review of current lipid signaling research places emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. The regulation of phospholipase C, phospholipase D, phosphoinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are covered in depth. There is specific discussion of the PH and FYVE lipid domains that allow lipids to control the movement, location, and activation-state of membrane proteins.
Z369985 Bioorganic Chemistry: Nucleic Acids This inaugural volume in a major new series focuses on nucleic acids from an organic chemical viewpoint. From the structure and function of DNA and RNA to chemical and enzymatic synthesis to alternative structures and structures of macromolecular complexes, this unique approach offers important insights into biology at the molecular level.
Z718351 C. elegans II Studies of the cells and genes of the nematode C. elegans have become a cornerstone of current biology. A classic 1988 Cold Spring Harbor monograph, The Nematode Caenorhabditis elegans, described the basic genetics, anatomy and development of the organism. Now, in that authoritative tradition, comes C. elegans II -- not a second edition but a book that breaks new ground and defines the current status of the field, providing a detailed molecular explanation of how development is regulated and the nervous system specifies varied aspects of behavior. This volume is a must for any investigator doing worm studies but it has been written and rigorously edited to illuminate for a wider community of investigators in cell and molecular biology who should know how new knowledge of C. elegans relates to their own specialty.
Z358851 Carbohydrate Analysis: A Practical Approach, 2nd ed. This book is the result of the need for a handbook of laboratory protocols in the complex field of carbohydrate analysis. Chapters are arranged on the basis of carbohydrate moiety to facilitate choice of analytical method for specific applications. New methods (supercritical fluid chromatography, capillary electrophoresis and NMR) have been added, while less used methods have been deleted.
Z705098 Carrier-bound Immobilized Enzymes: Principles, Applications and Design The first systematic overview of this key technique since the early 1990s, this authoritative reference is the only handbook available to include all recent developments. The author draws on his wide-ranging experience in both academia and industry to systematically cover all types of enzyme immobilization methods, including such novel techniques as site-specific immobilization, imprinting and immobilization in organic solvents. Throughout, a careful review of materials and techniques for the preparation of functional immobilized enzymes that benefits both developers and users of carrier-bound enzymes.
C3487 Cell Adhesion Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book provides a discussion of the structure and function of the major classes of cell adhestion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. Their role in processes such as cell mediated immunity, development and disease are discussed. The molecular organization and function of junctional complexes are also examined.
Z705578 Cell Biology Protocols As a modern composite scientific discipline, cell biology has expanded rapidly in recent years. Cell biologists now require a wide range of techniques, including those of analytical biochemistry and microscopy in all its diverse forms. These are often used alongside the techniques of molecular biology and molecular genetics. This book contains numerous useful protocols, covering light and electron microscopy, cell culture, cell separation, subcellular fractionation, organelle and membrane isolation, and the use of in vitro reassembly systems in cell biology. Many of these protocols feature helpful notes and safety information for practical application. The format favors easy use at the bench with space for notes and important safety information. An appendix contains essential analytical information that will prove invaluable.
Z704865 Cell Biology: A Laboratory Handbook, 3rd ed. 4 volume set This four-volume laboratory manual contains comprehensive state-of-the-art protocols essential for research in the life sciences. Techniques are presented in a step-by-step fashion, providing useful tips and potential pitfalls. The important steps and results are beautifully illustrated for further ease of use. This collection enables researchers at all stages of their careers to embark on basic biological problems using a variety of technologies and model systems. This thoroughly updated edition contains 165 new articles. Topics covered include:
Cell and Tissue Culture: Associated Techniques, Viruses, Antibodies, Immunocytochemistry (Volume 1); Organelle and Cellular Structures, Assays (Volume 2); Imaging Techniques, Electron Microscopy, Scanning Probe and Scanning Electron Microscopy, Microdissection, Tissue Arrays, Cytogenetics and In Situ Hybridization, Genomics and Transgenic Knockouts and Knock-down Methods (Volume 3); Transfer of Macromolecules, Expression Systems, Gene Expression Profiling (Volume 4)