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Cell Signaling books

Life Science and Chemistry books

Our Cell Signaling and Neuroscience books provide resources for cell signaling, signal transduction, insulin pathway biology, neuroscience, and Alzheimer's Disease research.

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Image	Product #	Book Title	Description
	Z702595	A-β Metabolism and Alzheimer’s Disease	This book explores the aggregation of amyloid-β peptide in the brain which plays a primary role in the pathogenesis of Alzheimer’s disease. It provides current information regarding generation, degradation within the brain, and transport out of the brain.
	Z705187	Adrenergic Receptors in the 21st Century	An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
	Z703702	Amyloid Precursor Protein: A Practical Approach	Amyloid precursor protein (APP) is an extensively studied transmembrane protein, and its derivative, amyloid β-protein, has been implicated as the primary cause of Alzheimer's disease. In the search for an effective treatment, APP is a unique model protein that illustrates the wide array of techniques available for characterization. This book presents a variety of biological techniques to elucidate the structure and function of this transmembrane protein. Each technique is presented with detailed protocols to achieve reproducible results and provide a framework for studying other membrane proteins. These protocols also form the core of the authors' approaches to elucidating the function of APP. This book contrasts methods to explain how the development of biological techniques affects the way molecular targets are examined.
	A8721	Angiogenesis Protocols	Although angiogenesis-formation of new blood vessels from pre-existing ones-has emerged as a target for the treatment of many disorders, fundamental aspects remain poorly understood. To address those needs, this book is a collection of key techniques for assessing the formation of new blood vessels in both whole tissue and cell culture. The methods range from low-cost in vitro assays to cutting-edge in vivo models. Included are details of the associated techniques for the isolation, identification, and culture of microvessel endothelial cells from human adipose tissues, and for the transfection and transduction of primary human endothelial tissues.
	A9843	Apoptosis Detection and Assay Methods	This book provides cutting-edge methods in apoptosis detection, and broad in-depth coverage of current apoptosis research methodologies. Step-by-step protocols for apoptosis detection, such as use of the apoptotic cell surface marker annexin V assay, single strand DNA antibody assays, caspase substrate assays, and several improved ways of detecting oligonucleosomal fragments are detailed. This book contains updated, comprehensive reviews of apoptosis technology development and applications, including the FACS method, in vitro biochemical approaches, and newly emerging yeast methods.
	Z702668	Apoptosis Methods and Protocols	A collection of cutting-edge techniques for detecting and quantifying apoptosis, understanding its biochemistry, and for identifying the genes and proteins that regulate and carry it out. Described in detail, these reproducible methods range from flow cytometry and immunohistochemical procedures to kinase activity assays, yeast two-hybrid screening, and the cloning of novel genes by differential expression. This book constitutes a key technical reference to the significant methodologies used in the field and powerful tools to illuminate the phenomenon of programmed cell death.
	A6975	Apoptosis Techniques and Protocols, 2nd ed.	This edition describes in detail state-of-the-art techniques for studying neuronal cell death. These methods solve a variety of research problems that include the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, and caspases), the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. Included are hands-on methods for the study of apoptosis mechanisms in neuronal compartments, for studying synaptosis, and for establishing gene expression profiles in neurodegenerative brain tissues by using DNA microarrays.
	Z700711	Apoptosis and Autoimmunity: From Mechanisms to Treatments	This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.
	Z340677	Apoptosis: A Practical Approach	This text provides conceptual outlines and detailed procedures for basic and advanced studies of cell death by apoptosis. Chapters on the recognition of apoptosis as distinguished from necrosis and nonspecific cell DNA damage are followed by a systematic examination of the established and the principal noval methodologies utilized in apoptosis research.
	A7101	Apoptosis: the Molecular Biology of Programmed Cell Death	Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. It is thought critical to maintenance of homeostasis and is implicated in lowering susceptibility to tumor growth. Conversely, oversensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as in neurodegenerative diseases. This book examines molecular pathways regulating apoptosis, progressing from the nematode worm through Drosaphila to more complex pathways evident in mammalian cells. Differences in cell death pathway within specific tissues are addressed, as are different genes that may act to regulate progressive steps.
	B8305	Beyond Neurotransmission	This book provides the foundations for understanding the cellular and molecular basis for neuromodulatory effects. It illustrates key examples of the roles played by neuromodulation in sensory processing, neuromuscular transmission, generation of motor behaviors, and learning. The book also underscores the importance of information processing by the nervous system in future studies. By spanning the levels of analysis from sub-cellular mechanisms through cellular properties and neuronal systems to behavior, the book provides a framework for understanding this field.
	B6308	Biochemistry of Cell Signalling	This will serve as a reliable map through the maze of cell signaling pathways and help the reader understand how malfunctions in these pathways can lead to disease. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. Part 2 describes the implementation of the signaling cascades focusing on the effect on gene transcription. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer.
	Z701297	Biochemistry of Signal Transduction and Regulation, 3rd ed.	This book has become the "gold standard" in the field of signal transduction and offers unmatched quality from the pen of a single author. The author succeeds in balancing comprehensive coverage with a clear and didactic style. The new edition is completely updated. 50% of the content has been rewritten to incorporate recent findings, and many illustrations have been redrawn and are now presented in full color.
	B4556	Biology of Phosphoinositides	This review of current lipid signaling research places emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. The regulation of phospholipase C, phospholipase D, phosphoinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are covered in depth. There is specific discussion of the PH and FYVE lipid domains that allow lipids to control the movement, location, and activation-state of membrane proteins.
	Z704717	Calcium Signaling Protocols, 2nd ed.	This extensively updated and expanded second edition contains new chapters on the electrophysiological measurement of Ca2+ channel activity, enhanced coverage of confocal microscopy, and practical tutorials on two of the most common industrial high-throughput machines, the Fluormetric Imaging Plate Reader (FLIPR), and the FlexStation. All experimental chapters provide readily reproducible techniques for measuring the many facets of Ca2+ signaling. The protocols offer step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
	Z705225	Calcium Signaling, 2nd ed.	In this edition, Putney focuses on those processes that generate calcium signals to compile the first comprehensive exploration of calcium signaling research from a methodological standpoint. This edition deals with methods for studying calcium from a variety of perspectives. Several chapters discuss calcium indicators and other tools, and look at microscopic and electrophysiological techniques, as well as other special methodological aspects of calcium signaling research. Other chapters examine the study of different systems, ranging from those found in yeast to those found in mammals, and several more are devoted to the cellular and molecular basis for calcium signaling, including explorations of receptors, calcium pumps, apoptosis, and drug delivery.
	C3362	Calcium-Binding Protein Protocols, Vol. 2: Methods and Techniques	Researchers review protein chemistry and behavior of this class of proteins, and provide experimental techniques for studying it both in vitro and in vivo. This second volume focuses on techniques for studying the solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding proteins in general. In addition to enzymatic assays and more routine spectroscopic and protein chemistry techniques, there are also NMR approaches, thermodynamic analyses, kinetic measurements such as surface plasmon resonance, strategies for amino acid sequence alignments, and fluorescence methods to study the distribution of calcium and calcium-binding proteins in cells.
	Z701785	Caspases: Their Role in Cell Death and Cell Survival	The volume offers insight into the key research topics that involve caspases. Leading experts from various areas of biology and medicine have compiled this volume so that both the novice and the professional will use this as the main reference for caspases for years to come. The reader will learn about the role of caspases in apoptosis signaling, inflammation and cancer therapy while being updated on the methodology used to study caspases and the efforts of pharmaceutical research in targeting caspases.
	Z704806	Cell Biology of Addiction	This monograph, written by experts in the field, is devoted to the molecular analysis of addiction pathways in the brain. It provides an intensive overview of the fundamentals, state–of–the–art advances, and major gaps in the cell and molecular biology of drug addiction within the broader context of neuroscience. Addiction research is a branch of neuroscience and psychology. The emphasis in this book is on hard science and the market for it will be found among research investigators and grad students within the field of neuroscience. The research presented is not only applicable to the study of drug abuse and addiction, but has clear implications for clarifying mechanisms of learning and memory, neuroadaptation, perception, volitional behavior, motivation, reward, and other disciplines of neuroscience.
	Z701750	Cell Biology: A Short Course, 2nd ed.	Taking an "essentials only" approach, this text, a completely revision of the earlier textbook From Genes to Cells, tells the story of cells as the unit of life in an accessible, user-friendly manner. The authors combine their expertise to skillfully present key points and illustrate them with clear diagrams and numerous examples from current research. This book offers: a unified presentation of cell biology in both medicine and industry with extensive cross-referencing; copious illustrations that make material clear and easy to understand; numerous boxed inserts that tie concepts to real-world research and developments in medicine and industry; a detailed, complete description of intercellular signaling.
	Z701866	Cell Cycle Checkpoint Control Protocols	A collection of cutting-edge techniques for studying the mechanisms underlying cell cycle regulation and checkpoint control. Using mammalian, yeast, and frog systems, these readily reproducible methods can be used to induce cell cycle checkpoints, detect changes in cell cycle progression, identify and analyze genes and proteins that regulate the process, and characterize chromosomal status as a function of cell cycle phase and progression. Each fully tested technique includes step-by-step instructions, an introduction explaining the principle behind the method, equipment and reagent lists, and tips on troubleshooting and avoiding known pitfalls
	Z369446	Cell Cycle Control	This is the first book to cover the cell cycle field in the wake of groundbreaking research from the past five years. A historical look at cell cycle findings places this new knowledge into perspective and demonstrates the universality of cell cycle control, from the evolutionary process to cancer research and mitotic regulation.
	Z703753	Cell Cycle Control: Mechanisms and Protocols	This collection of techniques for the study of the eukaryotic cell cycle and its key regulatory molecules includes overviews of cell cycle regulatory mechanisms in many major research organisms. Described in step-by-step detail, these reproducible methods enable fundamental research on well-defined cell cycle regulators and those more recently defined in yeasts, bacteria, plants, Drosophila, Xenopus, and mammals. The book offers all cell researchers indispensable techniques essential to understanding how normal cells divide and how this is altered in disease.
	Z702528	Cell Growth: Control of Cell Size	Recent breakthroughs in the field of cell growth, particularly in the control of cell size, are reviewed by experts in the three major divisions of the field: growth of individual cells, growth of organs, and regulation of cell growth in the contexts of development and cell division. This book is an introductory overview of the field and should be adaptable as a textbook.
	Z719242	Cell Imaging: Methods Express Series hard cover	Cell Imaging: Methods Express covers the key techniques that can be employed in any lab with access to cell imaging equipment, even if they do not currently specialize in imaging. It focuses on live cell imaging and light microscopy applications, but many of the techniques and approaches are equally relevant to the imaging of fixed specimens The topics in this comprehensive research guide include: Confocal versus widefield imaging; Transmitted light imaging; Photobleaching and photoactivation; Deconvolution and 3D reconstruction; Spectral imaging; Quantification and image analysis; Imaging calcium signals and activation of calcium binding proteins; Fluorescence Resonance Energy Transfer; Total Internal Reflection Fluorescence Microscopy; Correlative light-electron microscopy; Fluorescence Lifetime imaging; High Content and High Throughput imaging
	Z719234	Cell Imaging: Methods Express Series soft cover	Cell Imaging: Methods Express covers the key techniques that can be employed in any lab with access to cell imaging equipment, even if they do not currently specialize in imaging. It focuses on live cell imaging and light microscopy applications, but many of the techniques and approaches are equally relevant to the imaging of fixed specimens The topics in this comprehensive research guide include: Confocal versus widefield imaging; Transmitted light imaging; Photobleaching and photoactivation; Deconvolution and 3D reconstruction; Spectral imaging; Quantification and image analysis; Imaging calcium signals and activation of calcium binding proteins; Fluorescence Resonance Energy Transfer; Total Internal Reflection Fluorescence Microscopy; Correlative light-electron microscopy; Fluorescence Lifetime imaging; High Content and High Throughput imaging
	C1729	Cell Neurobiology Techniques	This book details cutting-edge techniques and readily reproducible methods for establishing neural cell cultures, measuring enzymes and their inhibitors, and using quantitative autoradiography to study monoamine uptake sites and receptors in the brain. Additional methods cover the use of flow cytometry to study developmental neurobiology, applications of magnetic resonance spectroscopy (MRS) to human brain metabolism, and the study of drug metabolism.
	Z730416	Cell Signalling, 2nd ed.	Cell Signalling presents a carefully structured introduction to this intricate subject, introducing those conserved features which underlie many different extra-and intracellular signalling systems. Starting with an overview of cell signalling, which highlights its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create the signalling pathways, which are so crucial to the survival of all living organisms.
	Z705705	Cell-Cell Interactions: Methods and Protocols	A versatile collection of readily reproducible cell–cell interaction assays for uncovering cellular interactions at the molecular level, both in vitro and in vivo. The protocols cover a diverse set of cell–cell interaction models in both normal and pathological states, are readily adaptable to nearly any cell type and organ system, and include primary data and outcome analysis. In addition, the protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls
	Z369713	Cellular Aging and Cell Death	This book bridges the rapidly growing fields of cellular aging and programmed cell death. It presents an authoritative overview of both fields, and demonstrates how both fields are critical to understanding the aging process. The role of apoptosis in a variety of age-associated diseases and disabilities is also covered.
	C9728	Cerebral Signal Transduction	This book emphasizes the functional role of the various signaling pathways in memory, apoptosis and degeneration, depression, and drug dependence in both health and diseases states. With the ability to selectively remove, reduce or enhance specific components of the signaling pathways, the book highlights the varied signaling cascades, their crosstalk and possibilities for changes in gene expression underlying changes in brain function. It discusses the development of novel therapeutics targeting downstream events in the cascade of second, third and fourth messengers.
	Z362352	Communication within Animal Cells	A clearly written textbook with many illustrations for students in advanced undergraduate and graduate courses. It puts into perspective a large body of knowledge about intracellular signaling systems.
	C1858	Connexin Methods and Protocols	Volume 154 in Methods in Molecular Biology Series describes the best techniques to study cellular and molecular biology of connexins, as well as physiological properties. These methods are specifically designed to investigate the life of connexins from biosynthesis to assembly into gap junction channels, and include powerful assays to perform functional studies on these routes of cell-cell communication. It offers a collection of methods for studying the role of connexins in intercellular communication and human genetic disorders, as well as finding new therapeutics.
	C2481	Cytokine Cell Biology: A Practical Approach	This focuses on cell biology techniques for studying cytokines, cytokine receptors, and cytokine driven processes. Assays for human B cell responses, leucocyte migration, haematopoietic growth factors, macrophage activation by cytokines, RIA, IRMA, and ELISA assays, and quantitative biological assays for cytokines are covered. There are chapters on studying cytokine regulation of endothelial cells, the measurement of proliferative, cytostatic, and cytolytic activity of cytokines, and the use of flow cytometry and intracellular fluorescent staining
	Z701629	Cytokine Handbook, 4th ed. 2 volume set	The fourth edition provides encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes with contributions from more than 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for anyone interested in cytokines and working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.
	Z701467	Cytokine Knockouts, 2nd ed.	Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.
	C2606	Cytokine Molecular Biology: A Practical Approach	This manual concentrates on molecular biology techniques for the study of cytokines, cytokine receptors, and cytokine driven processes. Topics include the cloning and expressing of cytokine genes, the analysis of cytokine mRNA by RT-PCR, cDNA array systems and