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Drug Discovery books

Best Books for the Best Minds

Our Drug Discovery books offer the drug discovery and bioassay research community resource information on assay development and screening for new drugs.

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Image	Product #	Book Title	Description
	Z705853	Analogue-Based Drug Discovery	The easiest way to create a new drug is to modify an existing one. These so-called drug analogs account for about half of all "new" drugs. In addition, drug analogs can be modeled on naturally occurring bioactive substances that do not make good drugs on their own. This first authoritative overview discusses analog-based drug discovery for, among others, beta-blockers, ACE inhibitors, steroids, opiates, coxibs, stigmines, proton pump inhibitors, platinum compounds and quinolones. In addition, case studies on selected commercially successful drug analogs provide prime advice for new drug development projects based on modification. The book has an exclusive table of the 1,000 most successful drug analogs according to IMS ranking, classified in terms of chemical structure, mode of action and patentability. It is officially endorsed by the IUPAC's Drug Development Committee.
	Z555509	Analysis and Purification Methods in Combinatorial Chemistry	Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. This book describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. It also provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.
	Z379794	Antisense Technology: A Practical Approach	Use of antisense oligonucleotides is a powerful technique for silencing specific genes, but it requires careful optimization and species-specific methods for success. Each chapter is written by an acknowledged expert with a record of success at the bench; each includes authoritative guidance, tips for success, and trouble-shooting advice.
	Z370010	Antisense Therapeutics	An authoritative survey of this fascinating strategy for drug discovery: using complementary oligonucleotides to block expression of disease-associated genes. Contributors discuss selection of gene targets, synthesis of oligonucleotides, routes of administration, and issues of pharmacokinetics. Current research on anti-viral drugs, cancer treatment, and therapies for genetic disorders is summarized.
	Z704008	Applying Genomic and Proteomic Microarray Technology in Drug Discovery	The book covers the issues surrounding gene expression and protein microarrays for pharmacogenomic and pharmacoproteomic applications. The author critically assesses those studies that have helped define applications in genomics and proteomics, explains gene expression microarray applications, and examines the utility of the protein microarray. He covers alternative substrates and the preparation of various surface chemistries together with their suitability for immobilization of nucleic acids and proteins. He delineates the mechanics of microarraying including environmental conditions, printer and pin performance. The book supplies protocols for printing nucleic acids and proteins and a discussion of other important parameters such as print buffers (inks) and factors influencing print quality.
	Z700843	Beginner’s Guide to Microarrays	The manufacture, experimental design, and analysis of microarrays are not always straightforward, and researchers run into roadblocks that hinder progress. This book is directed to the core facility manager who produces, hybridizes, and scans arrays, and the research scientist who will be performing the analysis and interpreting the results. It provides a user friendly coverage and protocols for the technical steps and procedures involved in many facets of microarray technology, including: Coating glass slides; Designing oligonucleotide probes; Troubleshooting spotting problems; Normalizing background signal and controlling for systematic variance; Analyzing data with statistical procedures.
	B5056	Bioinformatics Basics: Applications in Biological Science and Medicine	Scientists use an extensive databank to access structural information on proteins and nucleic acids and a specialized form of software to analyze the hybridization pattern of DNA chips. The success of biotechnology and pharmaceutical industries has been a result of technical advancements in genomics, proteomics, and bioinformatics. This book describes the organization of public domain databases with a tutorial for the services described. It concentrates on three major database clusters and relevant software tools that are maintained in the US, Europe, and Japan.
	Z704415	Bioinformatics and Drug Discovery	A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.
	B2931	Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, 2nd ed.	The second edition covers the broad spectrum of topics in bioinformatics, ranging from Internet concepts to predictive algorithms used on sequence, structure, and expression data. It includes: (a) all new end-of-chapter Web resources, bibliographies, and problem sets, (b) accompanying Website containing the answers to the problems, as well as links to relevant Web resources, (c) new coverage of comparative genomics, large-scale genome analysis, sequence assembly, and expressed sequence tags, (d) a glossary of commonly used terms in bioinformatics and genomics.
	B8308	Bioinformatics: From Genomes to Drugs, 2 Volume Set	Bioinformatics promises to revolutionize the process of drug discovery and development. This book provides an application-oriented overview of this technology. In addition, the state-of-the-art in bioinformatics is evaluated from a global view by introducing real application scenarios such as genome projects that require the use of a whole set of bioinformatics tools. The knowledge on bioinformatics presented enables readers to go beyond a mere push-button approach to using bioinformatics software and interpreting the data generated, but also to assess the potential and limitations of today's bioinformatics software and future challenges.
	B4306	Bioinformatics: Sequence and Genome Analysis	Application of computational methods to DNA and protein science is an exciting development. This book features sequence alignment, structure prediction, phylogenetic and gene prediction, database searching, and genome analysis that are clearly explained and illustrated along with underlying algorithms and assumptions. Theoretical underpinnings are linked to biological problems and solutions. Extensive tables provide descriptions and Web sources for a range of available software. An associated Website, accessible free of charge by book purchasers, provides links to Internet sources referred to in the text (http://www.BioinformaticsOnline.org).
	B8161	Bioinformatics: Sequence, Structure and Databanks, A Practical Approach	Covers practical important topics in the analysis of protein sequences and structures. It compares amino acid sequences to structures comparing structures to each other, and presents searching information on entire protein families as well as searching with single sequences. It shows how to set up and use the SRS molecular biology database management system. There are chapters on multiple sequence alignment and protein secondary structure prediction.
	Z701017	Burger’s Medicinal Chemistry and Drug Discovery^® 6th ed.,Volume 1: Drug Discovery	This edition of Dr. Burger’s classic helps researchers with both traditional and state-of-the-art principles and practices governing new medicinal drug research and development. Completely revised to reflect the many changes that have occurred in the field, it brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery. This volume contains new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery.
	Z702609	Chemical Genomics	The most comprehensive reference on this new and rapidly accelerating area of biotechnological innovation.This highly interdisciplinary reference/text identifies and elucidates the most influential developments in chemical genomics for improved research and advancement in a diverse array of fields ranging from proteomics, bioinformatics, and microfluidics to drug discovery and toxicology.
	Z704393	Chemical Genomics: Reviews and Protocols	An up-to-date introduction for the uninitiated into the various “flavors” of chemical genomics with a series of readily reproducible techniques for applications in organic chemistry, protein chemistry, and computer science, emphasizing the high-throughput approaches that are the essence of chemical genomics. The techniques range from the classic design of small molecules as affinity ligands for specific protein families, to in silico docking for computational approaches to protein–small molecule interactions, to producing highly diverse collections of proteins, carbohydrates, and small molecules for use in arrays containing large numbers of these molecules. There are also methods for the production of proteins and carbohydrates using different expression systems, for analyzing proteins using mass spectrometry, and for arraying proteins and carbohydrates on solid supports.
	Z703478	Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective	Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and from leading pharmaceutical companies, this book is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
	Z702676	Chemoinformatics: Concepts, Methods and Tools for Drug Discovery	The authors explain the theory behind the crucial concepts of molecular similarity and diversity, describe the challenging efforts to use chemoinformatics approaches to virtual and high-throughput screening, and illuminate the latest developments in multidimensional QSAR analysis. Other topics of interest include the use of partitioning algorithms and classification methods for analyzing large compound databases, screening sets, and virtual screening for active molecules; different approaches to target class-specific library design; and the generation of a novel class of molecular surface properties descriptors that can be readily calculated from 2D representations of molecular structures.
	Z702455	Chirality in Drug Design and Development	Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals -- supporting researchers as they critically evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds.
	Z411604	Combinatorial Chemistry and Molecular Diversity in Drug Discovery	This book highlights the critical concepts and issues involved in implementing combinatorial chemistry to create chemical libraries. It not only covers both the techniques and tools used in this field, but also the organizational and strategic questions faced by pharmaceutical managers. The authors apply combinatorial technologies to drug discovery and development and place co-evolving technologies and practices in a global framework. Included among the many topics are Library strategy and design; Solid-phase synthesis; Small molecular libraries; Automation, analytical, and computational methodology; Biological diversity; Strategies for screening combinatorial libraries; Combinatorial drug screening and development.
	Z539937	Combinatorial Chemistry: A Practical Approach	This book shows that modern combinatorial synthesis is possible not only in the solid phase, but also in solution. Moreover, it discusses computer-assisted methods as well as the apparatus and instrumentation required for the combinatorial method. Successful and experienced researchers offer their well-founded insight and perspective into this diverse field.
	C8476	Combinatorial Chemistry: A Practical Approach	Being a powerful modern technology, combinatorial chemistry has had implications in many areas of chemistry and biology, and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation, and explains the use of automation and robotics.
	Z287598	Combinatorial Chemistry: Synthesis and Application	Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Includes examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available.
	Z424277	Combinatorial Chemistry: Synthesis, Analysis, Screening	Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book. The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry.
	Z422509	Combinatorial Index	This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled "Points of Interest," which highlights the strengths and weaknesses of the various studies. The index covers the use of solution-based synthesis for the generation of molecular diversity and includes a structural appendix showing functional group transformations.
	Z513733	Combinatorial Library Design and Evaluation: Principles, Software Tools, and Applications in Drug Discovery	This book traces the latest advances in rational drug discovery and combinatorial library design, covering basic principles, design strategies, methodologies, software tools and algorithms, and applications. Specific topics include fast continuum electrostatics methods for structure-based ligand design, knowledge- based approaches for the design of small-molecule libraries for drug discovery, relative and absolute diversity analysis of combinatorial libraries, and design of combinatorial libraries that mimic biological motifs.
	Z700665	Combinatorial Library: Methods and Protocols	A panel of expert researchers have collected a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of such combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR.
	Z514764	Combinatorial Strategies in Biology and Chemistry	Combinatorial chemistry has taken the pharmaceutical industry by storm over the past ten to fifteen years. There has been a massive investment in automation by pharmaceutical companies and a demand for graduates/PhDs with experience and knowledge of combinatorial chemistry. These days the academic education of chemists and biologists is gradually converging, so those entering the pharmaceutical industry need to be not only chemistry graduates but also biologists applying their biological knowledge to chemistry. Many chemists, however, still require experience in biological methods and similarly biologists have not yet realized the power of chemical methods. This book will therefore help ease the transition from biology into chemistry and vice versa, for those working in the combinatorial chemistry field. Because combinatorial chemistry evolved from the requirements of the biology field, the authors have written this book with both biologists and chemists in mind. Combinatorial chemistry is a new and highly influential area of modern synthetic chemistry based on efficient, parallel synthesis of molecules, as opposed to the use of several synthetic steps, to produce many sets of compounds for biological evaluation. The techniques used in this area are key to the discovery of new drug compounds in the pharmaceutical and agrochemical industries. Combinatorial Methods in Chemistry and Biology describes the origins, basics and techniques used both in combinatorial chemistry and molecular biology.
	Z702234	Computational Medicinal Chemistry for Drug Discovery	Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized for ligand deisgn. This book examines molecular mechanics, semi-empirical methods, wave function-based quantum chemistry, density functional theory, 3-D structure generation, conformational analysis and hybrid methods. It views pharmacophore discovery and the use of 3D pharmacophore models in 3D database searching and studies vibrational circular dichroism spectroscopy for the stereochemical characterization of chiral molecules.
	Z700320	DNA Array Image Analysis: Nuts & Bolts	DNA Microarrays are an indispensable tool in molecular biology, which allows researchers to gain insight into the intricate mechanisms of gene expression. Common to all array-based technologies is the necessity to analyze digital images of the scanned DNA array. This book emphasizes aspects of both theory and application. It offers the basics of machine vision and image analysis for biologists, "how-to" approach to microarray image analysis, and practical tips for both the novice in the field and the advanced user.
	D6064	DNA Arrays: Methods and Protocols	Microarray technology is used in research of gene expression, mutation analysis, proteomics and gene sequencing. Protocols provide instruction in designing and constructing DNA arrays as well as hybridizing them with biological samples for analysis. Details include how to attach or print arrays on various matrices, biological sample preparation (DNA and RNA), hybridization conditions, signal detection, probe optimization, different printing technologies and data collection and analysis. Other topics are genotyping, sequencing by hybridization, antisense reagents, gene expression analysis, and business aspects of biochip technology.
	D5565	DNA Arrays: Technologies and Experimental Strategies	A giant leap in technology took place with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of thousands of genes. This book offers a view of different aspects of this rapidly developing technology, including oligonucleotides and electrochemical arrays. Up-to-date insights into methodological fundamentals of construction of DNA arrays, optimization of hybridization conditions, the use of expression data in bioinformatics, different software tools, and the application of microarray technology for drug discovery process are provided.
	D5440	DNA Microarrays: A Molecular Cloning Manual	DNA microarray, or DNA chip technology is a new and powerful means of discovering, characterizing and analyzing genes and their expression patterns. This manual assembles and synthesizes the expertise of over 30 innovators in this emerging field to provide authoritative, detailed instruction on the design, construction, and applications of microarrays, as well as comprehensive descriptions of the software tools and strategies required for extensive image and data analysis. It complements the best selling manual "Molecular Cloning".
	D6187	DNA Microarrays: A Practical Approach	Written and edited by experts in the field, this book provides valuable insight into the remarkable advancement of DNA microarrays. It is essential for researchers investigating patterns of gene expression and useful for all those interested in the use of biochips.
	Z700185	DNA Microarrays: Gene Expression Applications	This complete and practical manual on expression measurement using DNA arrays covers the existing methods (from nylon macroarrays to oligonucleotide chips) and includes detailed protocols. It has been written by scientists who have experienced the difficulties involved in actually using microarrays, and provides helpful advice and hints on setting up these powerful but tricky methods. Software, data mining procedures and probable future developments, which should be useful to anyone interested in expression measurement, are also covered. It provides detailed protocols as well as many helpful hints to achieve experimental success and to avoid pitfalls.
	Z704504	Drug Discovery Handbook	This book gives professionals a tool to facilitate drug discovery by bringing together for the first time, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology; Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more; Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques.
	D5066	Drug Discovery and Design: Advances in Protein Chemistry, Volume 56	Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents.
	Z701025	Drug Discovery and Evaluation: Pharmacological Assays, 6th ed.	This edition contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic respiratory, renal and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed CD-ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments will help one plan experiments more effectively.
	Z703370	Drug Discovery for Nervous System Diseases