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Molecular Biology books

Best Books for the Best Minds

Our Molecular Biology books cover various topics such as PCR, genomics, DNA sequencing and repair, microarrays, and cloning.

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Image	Product #	Book Title	Description
	Z702439	A-Z of Quantitative PCR	This is not just a cookbook for real-time quantitative PCR (qPCR). Admittedly, there are lots of recipes from distinguished contributors and Bustin has attempted to collect, sift through and rationalize the vast amount of information that is available on this subject. And yes, this book was conceived as a comprehensive hands-on manual to allow both the novice researcher and the expert to set up and carry out qPCR assays from scratch. However, this book also sets out to explain as many features of qPCR as possible, provide alternative viewpoints and methods and, perhaps most importantly, aims to stimulate the researcher into generating, interpreting and publishing data that are reproducible, reliable and biologically meaningful.
	Z704083	Analytical Techniques in DNA Sequencing	This text takes a look at the various DNA sequencing techniques that were developed and put to use during and after the Human Genome Project. Special attention is paid to the breakthrough Sanger Method, as well as to several other techniques that improved the accuracy, improved the detection limits, and in a variety of ways dramatically reduced the time needed to generate a DNA sequence. This volume describes the improvements in DNA separation based on advanced capillary electrophoresis and microchip sequencing. It also looks at the use of mass spectrometry and single molecule detection, and takes an in-depth look at the use of various fluorescence methods for the detection of sequencing fragments. One chapter is dedicated to chip-based microfabricated sequencing systems, which could well be the future of DNA sequencing.
	Z718262	Analyzing DNA	A genome revolution is transforming biomedical research in the leading laboratories. Now, a series of manuals from Cold Spring Harbor puts the tools of the revolution in everyone's hands. Assuming only a basic knowledge of molecular biology, these manuals explain how to clone, manipulate, analyze, and sequence large segments of DNA, and relate expressed sequence to phenotypic variation. The techniques are written for application to animal DNA as well as human genomes. They deal plainly with sources of failure - and solutions. Assembled by experienced CSH course instructors, the protocols are written by experts, often the methods' creators, and have been rigorously edited to Cold Spring Harbor standards of accuracy, consistency, and completeness. A complement to the bible of recombinant DNA, Molecular Cloning, these manuals are essential for every laboratory in which genes are being studied.
	Z705780	Aptamer Handbook: Fundamental Oligonucleotides and their Applications	In this book, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes). Basic concepts and technologies describing in detail how these functional oligonucleotides can be identified are presented. Numerous examples demonstrate the versatility of in vitro selected oligonucleotides. Special emphasis has been put on a section that shows the broad applicability of aptamers, e. g. in target validation, for analytics, or as new therapeutics. This first overview in the field is of prime interest for a broad audience of scientists both in academia and in industry who wish to expand their knowledge on the potential of new oligonucleotide functions and their applications.
	Z703028	B Cell Protocols	Recent advances in genetics, synergized by many exciting developments in cellular and molecular biology, have provided powerful new experimental tools for the study of not only B-lymphocyte development and function, but also the physiology and pathology of the immune system in higher animals. This book is a diverse collection of protocols ranging from the latest inventions and applications to some classic, but still frequently used, methods in B cell biology. These readily reproducible protocols follow the successful Methods in Molecular Biology series format.
	B7157	Baculovirus Expression Vectors: A Laboratory Manual	This laboratory manual simplifies the selection of the most appropriate vector design for a given problem and describes each step in the implementation process from vector construction to large-scale protein production.
	B5678	Basic Molecular Biology: Essential Techniques	Begins with a brief overview and then focuses on simple step-by-step protocols of the core techniques. It provides not only a theoretical outline, but also valuable advice on real-world problems and estimates on how much time is required to perform each technique.
	Z701718	Bioinformatics and Functional Genomics	Encompassing the field of bioinformatics, from sequence analysis, gene expression, microarrays, and proteomics to molecular phylogenics and whole genome studies, this text shows how bioinformatics applies to biological questions at different levels, such as gene/protein, disease, and protein structures. The author emphasizes practical skills, such as how to analyze genes and proteins, how to make trees using phylogenic software, how to extract data, and how to identify genes and proteins implicated in disease. It provides a systematic three-part format, beginning with the analysis of biological sequence data, continuing with functional genomics (from microarrays to proteomics), and ending with coverage of genomes.
	Z718599	Bioinformatics: Sequence and Genome Analysis	The application of computational methods to DNA and protein science is a new and exciting development in biology. Bioinformatics: Sequence and Genome Analysis is a comprehensive introduction to this emerging field of study. The book has many unique and valuable features: It is written for any biologist who wants to understand methods of sequence and structure analysis and how the necessary computer programs work Sequence alignment, structure prediction, phylogenetic and gene prediction, database searching, and genome analysis are clearly explained and amply illustrated Underlying algorithms and assumptions are clearly explained for the non-specialist Examples are presented in simple numerical terms rather than complex formulas and notation Theoretical underpinnings are linked to biological problems and their solutions Extensive tables provide descriptions and Web sources for a broad range of publicly available software. Based on the author's extensive experience as a molecular geneticist and bioinformaticist at the University of Arizona, this is a uniquely educational book, ideal as a laboratory reference for investigators and also as teaching reference for graduate and undergraduate students studying this fast-changing discipline.
	Z718637	Biological Responses to DNA Damage	Living cells have evolved many ways of coping with metabolic events and environmental influences that damage DNA. These mechanisms, and the frequent progression to cancer that results when they go awry, are reviewed in this volume by authors from over sixty of the world’s leading laboratories. The topics discussed include DNA repair, mutagenesis and other damage-tolerance functions, checkpoint control, apoptosis, and adaptation. They draw from studies on human and yeast cells. Current, but with a valuable historical perspective, this volume has the depth and lasting value typical of this most prestigious series and is essential reading for investigators of DNA replication, cell cycle control, and tumorigenesis.
	Z718645	Biological Responses to DNA Damage	Living cells have evolved many ways of coping with metabolic events and environmental influences that damage DNA. These mechanisms, and the frequent progression to cancer that results when they go awry, are reviewed in this volume by authors from over sixty of the world’s leading laboratories. The topics discussed include DNA repair, mutagenesis and other damage-tolerance functions, checkpoint control, apoptosis, and adaptation. They draw from studies on human and yeast cells. Current, but with a valuable historical perspective, this volume has the depth and lasting value typical of this most prestigious series and is essential reading for investigators of DNA replication, cell cycle control, and tumorigenesis.
	Z702838	Calculations for Molecular Biology and Biotechnology: A Guide to Mathematics in the Laboratory	This book is the first comprehensive guide devoted exclusively to calculations encountered in the genetic engineering laboratory. This guide, written for students, technicians, and scientists, provides example calculations for the most frequently confronted problems encountered in gene discovery and analysis. The text and sample calculations are written in an easy-to-follow format. It is the perfect laboratory companion for anyone working in DNA manipulation and analysis.
	C8360	Cell and Molecular Biology: Concepts and Experiments, 3rd ed.	This text balances coverage of the concepts of cell and molecular biology, using examples of experimentation to support those concepts. As experimental techniques become more diverse and complex, it is increasingly necessary to identify individual studies that have a broad impact on our understanding of cell biology. This text describes in detail some of the key experimental findings, along with the original data and figures. "CellView" interactive CD is included with text.
	Z364320	Cell and Molecular Biology: Essential Data Series	This handy reference brings together a wide range of core information needed by all researchers in the biomolecular sciences and additional selected information from the areas of biochemistry, cell biology, genetics and molecular biology.
	C1854	Chromatin Protocols	Collection of protocols is designed to analyze the relationship between chromatin structure and function, and to elucidate molecular mechanisms that control vital cellular functions such as transcription, replication, recombination, and DNA repair. Methods cover topics from cell-free systems for the constitution of chromatin heterogeneity in vitro, to techniques for in vivo analysis of protein–DNA interactions. Methods include instructions to ensure successful replication and to avoid pitfalls.
	C5224	Chromatin: A Practical Approach	This title provides clear explanations of a wide range of techniques from the initial isolation and fractionation of chromatin and linker histones, to the in vitro assembly of chromatin and nuclear structures in Xenopus egg extracts.
	C4862	Cloning and Expression Vectors for Gene Function Analysis	This describes the latest modifications to important and original research initially published in the leading methods journal BioTechniques. This new volume brings together, in one collection, some of the best articles published in the exciting field of gene cloning and protein expression and presents updated protocols selected from some of the most widely used techniques practiced in the modern molecular biology laboratory. Specific chapters include the latest information on constructing cDNA libraries, PCR conditions, choosing the correct expression system, and purification strategies.
	Z700592	Cloning, Gene Expression, and Protein Purification: Experimental Procedures and Process Rationale	This resource presents protocols for isolating a gene, cloning and characterizing it, expressing its encoded protein, and purifying and characterizing the protein's physical properties. It includes background and procedures and is structured around 20 experiments that demonstrate how to prepare, manipulate, and analyze plasmids, produce fusion proteins in bacteria, and purify these proteins based on chemical properties or substrate affinities. It describes topics such as the use of antibodies and techniques developed to transform their structures, and approaches designed to manipulate structure and functions of proteins and nucleic acids.
	Z718475	Coiled Spring: How Life begins soft cover	A concise, readable account of the principles underlying embryonic and appendage development in animals and plants, illustrated with colorful artwork and interviews with prominent investigators. Highly recommended for use in undergraduate and graduate courses.
	Z718467	Coiled Spring: How life begins hard cover	A concise, readable account of the principles underlying embryonic and appendage development in animals and plants, illustrated with colorful artwork and interviews with prominent investigators. Highly recommended for use in undergraduate and graduate courses.
	C2600	Concise Dictionary of Biomedicine and Molecular Biology on CD-ROM	The more than 23,000 entries include: • 4,000 chemical structures and their functions • 1100 equations of enzymatic reactions •approximately 600 restriction endonucleases and their specific activities •trade or brand names of drugs •mechanisms of action •medicinal applications of antibiotics.
	Z705357	Condensed Protocols from Molecular Cloning: A Laboratory Manual Hardback	Molecular Cloning: Condensed Protocols is a single-volume adaptation of the three-volume third edition of Molecular Cloning: A Laboratory Manual. The book contains only the step-by-step portions of the protocols, accompanied by the appendices. Each protocol is cross-referenced to the appropriate pages in the original book. This affordable volume, designed for bench use, offers individual investigators the opportunity to have their own personal collection of short protocols from the world's best-selling manual of molecular biology techniques.
	Z704881	Condensed Protocols from Molecular Cloning: A Laboratory Manual Paperback	Molecular Cloning: Condensed Protocols is a single-volume adaptation of the three-volume third edition of Molecular Cloning: A Laboratory Manual. The book contains only the step-by-step portions of the protocols, accompanied by the appendices. Each protocol is cross-referenced to the appropriate pages in the original book. This affordable volume, designed for bench use, offers individual investigators the opportunity to have their own personal collection of short protocols from the world's best-selling manual of molecular biology techniques.
	C2606	Cytokine Molecular Biology: A Practical Approach	This manual concentrates on molecular biology techniques for the study of cytokines, cytokine receptors, and cytokine driven processes. Topics include the cloning and expressing of cytokine genes, the analysis of cytokine mRNA by RT-PCR, cDNA array systems and in situ hybridization, the study of cytokine gene polymorphisms, the analysis of cytokine signaling via PC-specific phospholipase C and sphingomyelinases, the Jak/STAT and MAPK signaling pathways, and gene modification in transgenic and mutant mice.
	Z700320	DNA Array Image Analysis: Nuts & Bolts	DNA Microarrays are an indispensable tool in molecular biology, which allows researchers to gain insight into the intricate mechanisms of gene expression. Common to all array-based technologies is the necessity to analyze digital images of the scanned DNA array. This book emphasizes aspects of both theory and application. It offers the basics of machine vision and image analysis for biologists, "how-to" approach to microarray image analysis, and practical tips for both the novice in the field and the advanced user.
	D6064	DNA Arrays: Methods and Protocols	Microarray technology is used in research of gene expression, mutation analysis, proteomics and gene sequencing. Protocols provide instruction in designing and constructing DNA arrays as well as hybridizing them with biological samples for analysis. Details include how to attach or print arrays on various matrices, biological sample preparation (DNA and RNA), hybridization conditions, signal detection, probe optimization, different printing technologies and data collection and analysis. Other topics are genotyping, sequencing by hybridization, antisense reagents, gene expression analysis, and business aspects of biochip technology.
	D5565	DNA Arrays: Technologies and Experimental Strategies	A giant leap in technology took place with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of thousands of genes. This book offers a view of different aspects of this rapidly developing technology, including oligonucleotides and electrochemical arrays. Up-to-date insights into methodological fundamentals of construction of DNA arrays, optimization of hybridization conditions, the use of expression data in bioinformatics, different software tools, and the application of microarray technology for drug discovery process are provided.
	D4816	DNA Chromatography	This book describes DNA Chromatography a powerful and effective tool for the molecular biologist researcher. The technology is useful for a variety of applications including the analysis of mutations (SNPs, insertions, and deletions), the size determination of PCR products, the purification of single- and double-stranded nucleic acids, analysis of enzymatic reaction products and many others. DNA Chromatography is automated and can replace many of the gel electrophoresis technologies being used resulting in faster and more accurate analysis.
	Z362360	DNA Cloning: A Practical Approach, 2nd ed. Volume 1: Core Techniques	Topics include transformation, construction of cDNA and genomic libraries, probe preparation, analysis of gene organization and gene expression, in vitro mutagenesis, and DNA sequencing.
	Z362379	DNA Cloning: A Practical Approach, 2nd ed. Volume 2: Expression Systems	This volume provides essential information and full details of current procedures for the expression of cDNA clones in E. coli, lambda-phage, yeast, and baculovirus expression systems. Also covered are the isolation and purification of recombinant protein(s), and the generation of monoclonal and polyclonal antibodies.
	Z306193	DNA Cloning: A Practical Approach, 2nd ed. Volume 3: Complex Genomes
	Z306207	DNA Cloning: A Practical Approach, 2nd ed. Volume 4: Mammalian Systems	Topics covered include: high efficiency gene transfer into mammalian cells, use of vectors based on gene amplification, retroviral vectors, genetic manipulation of embryonic stem cells, production of transgenic rodents, genomic and expression analysis of transgenic animals, expression using a defective HSV-1 vector system, and adenovirus vectors.
	Z719005	DNA From The Beginning	DNA from the Beginning (a 3–CD set) is a multimedia primer on the basics of DNA, genes, and heredity. It is an ideal teaching tool for high school students and will also interest adults with a non-technical background who wish to learn more about the impact that DNA science is having on our lives. The content in DNA from the Beginning is built on a progressive series of important but simply stated concepts such as Children resemble their parents. An understanding of the concept is then conveyed in clear,understandable terms with the aid of links to animations, photographs, and video clips, and biographies or interviews featuring key scientists. A wealth of other information and links to web resources are included. Problems and their solutions are included to allow teaching through self-examination. Based on the award-winning web site, the DNA from the BeginningCD–ROM set provides over 72 hours of study time. It runs on Macintosh computers and PCs, and gives immediate access to all the online content, in attractive, uncluttered screens, without the need for network connections.
	Z719013	DNA Interactive DVD	DNA Interactive (DNAi) is a multimedia resource for high school and introductory college biology that shows how we came to understand the language of DNA, how we bend it to our own service, and what it can tell us about who we are. The DNAi products an award winning website (http://www.dnai.org) and the DVDare the result of a two year collaboration between scientists, educators, and film makers on three continents. It includes more than 200 video clips and animations; video interviews with 11 Nobel Laureates and more than 50 other scientists, clinicians, and patients; and spectacular 3 D animations that illustrate intracellular processes and explore aspects of DNA science.
	D4691	DNA Methylation Protocols	This book offers a set of readily reproducible protocols of the analysis of DNA methylation and methylases. These powerful methods provide the tools necessary for studying methylation at both the global level and the level of sequence, and include many techniques for identifying genes that might be aberrantly methylated in cancer and aging. Additional methods cover genome-wide analysis of abnormal DNA methylation and the isolation and measurement of demethylases and related proteins.
	Z704199	DNA Methylation: Approaches, Methods and Applications	A guide to understanding the complex regulatory roles of DNA methylation, this volume describes the relation that this biological mechanism has to gene silencing in disease and explores its promising role in treating cancer. The book is a state-of-the-art reference for understanding the role DNA methylation plays in human disease, particularly cancer. This compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book provides a balance between articles clarifying methodological details and more general review chapters.
	D5440	DNA Microarrays: A Molecular Cloning Manual	DNA microarray, or DNA chip technology is a new and powerful means of discovering, characterizing and analyzing genes and their expression patterns. This manual assembles and synthesizes the expertise of over 30 innovators in this emerging field to provide authoritative, detailed instruction on the design, construction, and applications of microarrays, as well as comprehensive descriptions of the software tools and strategies required for extensive image and data analysis. It complements the best selling manual "Molecular Cloning".
	Z718750	DNA Microarrays: A Molecular Cloning Manual	DNA microarray technology is a new and powerful means to analyze genomes and characterize patterns of gene expression. Its applications are widespread across the many fields of plant and animal biological and biomedical research. This manual, designed to extend and to complement the information in the bestselling Molecular Cloning, is a synthesis of the expertise and experience of more than 30 contributors - all innovators in a fast-moving field. DNA Microarrays provides authoritative, detailed instruction on the design, construction, and applications of microarrays, as well as comprehensive descriptions of the software tools and strategies required for analysis of images and data.