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Proteomics books

Best Books for the Best Minds

Our proteomics research books gives scientists a variety of resources on the dynamic nature of gene expression and regulation with protein profiling.

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Image	Product #	Book Title	Description
	P2481	2-D Proteome Analysis Protocols	Leading investigators in the field show how to make protein extracts, reproducibly run them on 2-D gels, detect them, analyze the data, and precisely identify each protein. The book covers the latest methods of using carrier ampholytes in the 1st dimension, casting and running immobilized pH gradient 2-D gels, MALDI-TOF-based peptide mapping, automated tandem mass spectrometry, and nanoelectrospray ionization technology. For the 2nd dimension, there are methods for running flatbed or vertical gels and for protein detection using autoradiography, and Coomassie, silver, and reversible metal-chelate stains.
	A9718	Actin	This book describes actins as highly conserved proteins found in virtually all eukaryotic cells. They have prolific roles in cell motility, from the contraction of striated muscle to the movement of organelles within cells, and are known to interact with a diverse number of proteins. This edition gives a comprehensive account of actin sequence, mutation, and structure as well as providing insight into ligand-binding sites and drug and toxin binding.
	A2719	Adhesion Protein Protocols	The cutting edge methods in this title will enable both novice and experienced researchers readily to identify and clone new adhesion proteins, to successfully produce inhibitors of the adhesive activity, to develop biological models for the assay of cell-to-matrix and cell-to-cell adhesion in vitro, and to measure the signaling activities of adhesion proteins. By illuminating these adhesive molecules and the possibilities for manipulating them, the new experimental strategies collected here will have considerable clinical potential for the regulation of immunity, inflammation, tissue remodeling, and embryonic development.
	Z374113	All About Albumin: Biochemistry, Genetics, and Medical Applications	Provides complete coverage of all aspects of serum albumin in one volume. It summarizes the chemistry, genetics, metabolism, clinical implications, and commercial aspects of this essential protein. Additionally, up-to-date sequences, structures, and compositions of many species can be found.
	A2344	Antibody Fusion Proteins	Antibody fusion proteins are genetically-engineered proteins that result from fusion of immunoglobin with non-immunoglobin cDNA sequences. Using different types of genetically-engineered fusion molecules from antibodies as examples, this book examines antibody fusion proteins which are being used for a number of clinical applications. It will guide the biotechnologist through the principles and applications of these proteins for use in research and clinical medicine.
	Z703079	Biomedical Applications of Proteomics	The first book to provide an overview over applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets. Examples of applications are presented for the most important diseases like heart and cardiovascular disorders, cancer, infectious diseases and diseases of the nervous system. Aspects of pharmatoxicology as well as bioinformatics are also included. Authors form the U.S., Europe and Australia contribute with their specific expertise.
	Z378305	Bioseparation of Proteins: Unfolding/Folding and Validation	A detailed critical review of literature on effectiveness, economics, and validation of bioseparation processes for drugs and other biological products. Key contents include: stability under various separation conditions case studies on methods development protein refolding and inactivation mechanisms. Coverage includes classical as well as modern bioseparation techniques.
	C3362	Calcium-Binding Protein Protocols, Vol. 2: Methods and Techniques	Researchers review protein chemistry and behavior of this class of proteins, and provide experimental techniques for studying it both in vitro and in vivo. This second volume focuses on techniques for studying the solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding proteins in general. In addition to enzymatic assays and more routine spectroscopic and protein chemistry techniques, there are also NMR approaches, thermodynamic analyses, kinetic measurements such as surface plasmon resonance, strategies for amino acid sequence alignments, and fluorescence methods to study the distribution of calcium and calcium-binding proteins in cells.
	Z702641	Capillary Electrophoresis of Proteins and Peptides	Expert academic and pharmaceutical researchers describe their best capillary electrophoresis techniques for protein and peptide analysis. The authors present cutting-edge techniques for both capillary coatings and analytic detection via laser-induced fluorescence, for the development and commercialization of biopharmaceuticals, and for affinity capillary electrophoresis in the evaluation of protein binding, including the use of protein charge ladders. Areas of special interest covered include combining CE and capillary isoelectric focusing with electrospray mass spectrometry detection to perform proteomic studies and applications in the field of protein-ligand binding
	Z704393	Chemical Genomics: Reviews and Protocols	An up-to-date introduction for the uninitiated into the various “flavors” of chemical genomics with a series of readily reproducible techniques for applications in organic chemistry, protein chemistry, and computer science, emphasizing the high-throughput approaches that are the essence of chemical genomics. The techniques range from the classic design of small molecules as affinity ligands for specific protein families, to in silico docking for computational approaches to protein–small molecule interactions, to producing highly diverse collections of proteins, carbohydrates, and small molecules for use in arrays containing large numbers of these molecules. There are also methods for the production of proteins and carbohydrates using different expression systems, for analyzing proteins using mass spectrometry, and for arraying proteins and carbohydrates on solid supports.
	Z703303	Chemical Reagents for Protein Modification, 3rd ed.	Revised and updated, the third edition is an encyclopedic work describing the many approaches to the site-specific modification of proteins. More than 2,000 references are cited describing the development of the various reagents. The book explores how the use of site-specific protein modification relates to a wide variety of biotechnology processes and products, such as protein microarrays, hydrogels, controlled-release pharmaceuticals, and biotherapeutics, and proteomics. This edition presents the most frequently used methods for the site-specific chemical modification of proteins, techniques for protein characterization, precise laboratory data for factors that influence reactivity and reproducibility, and industry-specific resources.
	C8430	Chemistry of Protein Conjugation and Cross-Linking	This book explains the mechanisms of chemical modification. It also surveys the bifunctional reagents used in bioconjugation and cross-linking, and provides a review of practical applications of these reagents.
	Z702161	Co- and Posttranslational Proteolysis of Proteins: the Enzymes Vol. XXII	This volume examines a number of different proteases, a type of enzyme, that are required in order for the change to a biologically active mature protein to occur. The discussion of these various proteases is rarely undertaken in one volume and will serve as a great resource for scientists studying the group of proteases on signal peptide processing as well as those working on propeptide processing. These areas of research do not normally overlap, and yet they are each of common importance to the same cell processes.
	Z701211	Directed Evolution Library Creation: Methods and Protocols	A compendium of cutting-edge protocols for the generation of molecular diversity. These protocols include reproducible methods for random mutagenesis of entire genes or segments of genes, for homologous and nonhomologus recombination, and for constructing in vivo libraries in bacteria and yeast. This volume also describes ways to analyze libraries, particularly those made by recombination. This volume describes methods for the creation of mutated DNA molecules, or DNA libraries, encoding variants of desired proteins. An accomapnying volume is Directed Enzyme Evolution: Screening and Selection Methods (see Z70,131-9)
	D5066	Drug Discovery and Design: Advances in Protein Chemistry, Volume 56	Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents.
	Z700622	E. coli Gene Expression Protocols	This book is a collection of popular and emerging methodologies that take advantage of E. coli's ability to quickly and inexpensively express recombinant proteins. The author's focus on two areas of interest: the use of E. coli vectors and strains for production of pure, functional protein, and the use of E. coli as host for the functional screening of large collections of proteins and peptides. Among the techniques demonstrated are those for rapid high-level expression and purification of soluble and functional recombinant protein and those essential to functional genomics, proteomics, and protein engineering.
	Z705217	Green Fluorescent Protein: Properties, Applications and Protocols, 2nd ed.	This text tackles both theory and practice, offering numerous case studies, examples, illustrations, and troubleshooting tips. It examines how Ps are tailored for specific systems and used to maximize expression, and how variants are generated with altered properties. The text also explores new ways to use FPs and methods for enhancing detection in a variety of organisms and cell types. This updated and expanded edition places emphasis on the rise of FPs and their applications in industry and biosensor research. It provides new chapters on FPs, biosensors, and advances in the use of FPs in the biotechnology and pharmaceutical industries, detailed information about protocols using FPs, and three-dimensional structure, and molecular biology and mutation of FPs.
	Z701890	HPLC of Peptides and Proteins: Methods and Protocols	Hands-on experts from academia and industry describe how to successfully perform all the critical HPLC techniques needed for the analysis of peptides and proteins. The methods range from commonly used techniques to those for capillary to large-scale preparative isolation. The authors have also presented a number of specific applications as case studies to illustrate the analytical approaches to a particular separation or assay challenge, with examples drawn from contemporary fields in biochemistry and biotechnology
	Z701289	Handbook of Proteomic Methods	A compendium of thirty-four powerful techniques for identifying and analyzing the diversity of proteins expressed in cells. These readily reproducible proteomic methods range from general to specific techniques, and include methods for data analysis, posttranslational modification, and its variants and isoforms. Additional methods demonstrate the application of proteomics to the discovery of serological tumor markers, to identifying the determinants of sensitivity to antitumor drugs, and to specialized fields, such as endocrinology, plant biology, nephrology, and urology.
	Z378283	Heparin-Binding Proteins	By way of review, this volume starts with the structure and biosynthesis of heparin and heparan sulfates (heparinoids). The remainder concentrates on the metabolism, characterization, and biological roles of heparinoid proteoglycans. Because they are so diverse, the discussion enters into hemostasis, lipoprotein metabolism, fibroblast growth factors, and superoxide dismutase activity. A brief but key discussion focuses on using affinity chromatography for purifying and analyzing proteoglycans.
	Z704016	Industrial Proteomics: Applications for Biotechnology and Pharmaceuticals	This book covers both basic elements and the state-of-the-art in applications of proteomics. The first section gives an introduction to the field, from differential approaches to functional proteomics, including yeast two-hybrid, mass spectrometry, mapping of post-translational modifications, and NMR spectroscopy. The second section offers a complete picture of industry studies in proteomics for human health and biotechnology applications. The final section addresses the future, looking at the most promising areas such as protein arrays and the integration of genomic and proteomic tools.
	I6029	Interpreting Protein Mass Spectra: A Comprehensive Resource	This guide for researchers investigating structures of proteins and peptides focusses on interpretation of structural information gathered through electrospray ionization-mass spectrometry (ESI-MS). It will also provide background and protocols for anyone using matrix-assisted laser desorption/ionization (MALDI), fast atom bombardment (FAB), and secondary ion mass spectrometry (SIMS). It includes practical examples, discussions of experimental setups, and hints for troubleshooting both methods and handling of materials.
	Z701033	Introduction to Macromolecular Crystallography	This book provides a comprehensive summary of the field of crystallography, fundamental theory of diffraction and properties of crystals, and applications in determining macromolecular structure. Without assuming a background in physics or math, book’s contents flow logically from basic principles to methods, such as those for solving phase problems, interpretation of Patterson maps, and the difference Fourier method. This introduction includes practical instruction on interpretation of data and methods for determining phases and also illustrates concepts throughout to clarify difficult ideas; integrates analogies to illuminate the text; equips the reader to employ the range of programs in crystallography.
	I3529	Introduction to Protein Architecture	The structures and functions of proteins unlock the secrets inherent in genomes. The emphasis is on proteins as three-dimensional patterns. It explains the general characteristics of proteins that underlie the great variety of folding patterns observed in nature. Topics treated include: Pattern and form in protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why).
	I0891	Introduction to Protein Structure, 2nd ed.	This edition gives an account of the principles of protein structure, with examples of key proteins in their biological context illustrated to illuminate the structural principles described. The first chapters introduce the general principles of protein structure. Subsequent chapters use specific examples of proteins to show how they fulfill a wide range of biological functions. It concludes with chapters on the experimental approaches to determining and predicting protein structure, as well as engineering new proteins to modify their functions.
	P0741	Introduction to Proteomics:Tools for the New Biology	This is an introduction to proteomics, a hot area in the biological sciences which enables scientists to study the protein complement of the genome. It refers to studying the functions of many proteins at one time, as opposed to how research was conducted in the mid-90's where the technology did not enable the study of the entire protein system. From this, one is able to develop an overview of the way a genome functions and the role it plays in health and disease.
	Z702242	Isolation and Purification of Proteins	This book discusses rational design of downstream protein processing; product release from cells and tissues by mechanical disruption, chemical agency and enzymatic lysis; genetic strategies to facilitate purification of recombinant proteins; solid-liquid spearation via centrifugation, flocculation, filtration and filter aids; the usage of membrane filtration for protein isolation; nonselective and selective precipitation; protein crystallization on a large scale; extraction in aqueous two-phase systems and expanded bed absorption for rapid protein isolation; robust, superporous chromatography matrices for in crude feeds, and more.
	M9937	Mechanisms of Protein Folding, 2nd ed.	Process by which polypeptide chains become their final 3-dimensional protein forms is clearly explained. Second edition incorporates significant improvements such as advances in interpreting observed kinetic data, development of technology to observe fast folding reactions, molten globule state, and vital role of chaperone proteins in protein folding. New discoveries of the central importance of protein folding and unfolding reactions in biology and medicine, including mutation and misfolding, are explored. Three case studies elucidate the difficulties of studying protein folding in vivo.
	Z701203	Membrane Protein Protocols: Expression, Purification, and Characterization	A collection of key techniques for the study of receptors and transport proteins. The book provides examples of how different membrane proteins can be overexpressed in both prokaryotic and eukaryotic expression systems, how natural and overexpressed proteins can be solubilized from their host membranes, and how the solubilized protein can be purified in active form. Each protocols contains step-by-step instructions, troubleshooting advice, lists of reagents, and tips on avoiding pitfalls.
	Z703737	Metabolomics by In Vivo NMR	This book is unique in linking in vivo ¹³C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states. It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders It will inspire future research directions
	Z702463	Methods and Results in Crystallization of Membrane Proteins	Parts I and II of this book deal with general principles and techniques in membrane protein crystallization in a clear and concise fashion, with an excellent general introdution followed by chapters covering the use of detergents, crystallization in lipidic cubic phases, the use and generation of antibody fragements, porin as a model and crystalliztion of membrane proteins in oil. Part III focuses on specific examples of membrane proteins whose structures have been solved. The examples cover the gamut of membrane proteins from those involved in photosynthesis to respiratory complexes to channels, receptors and the outer membrane protein phospholipase A.
	M9807	Microcharacterization of Proteins, 2nd Edition	This thorough introduction and laboratory guide details the most recent developments in protein separation and characterization, fragmentation and micro sequencing. It offers a stimulating combination of basic concepts and practical applications and presents the latest information in the rapidly emerging area of protein characterization.
	M9814	Modern Protein Chemistry: Practical Aspects	This is a lab cookbook covering all the advanced techniques for working with proteins. Simple directions for each technique are presented along with references, estimated of time, special equipment required, and points on troubleshooting. This gives researchers a "cost-benefit" analysis of these techniques. It also provides hands-on information to complement theoretical understanding. No other guide exists that enables a researcher to make a practical evaluation of these methods.
	Z703508	Modular Protein Domains	Since the full functionality of any given protein can only be understood in terms of its interaction with other, often regulatory proteins, this unique reference source covers all relevant protein domains, including SH2, SH3, PDZ, WW, PTB, EH, PH and PX. Its user-oriented concept combines broad coverage with easy retrieval of essential information, and includes a special section on Web-based tools and databases covering protein modules and functional peptide motifs. Essential for the study of protein-protein interactions in vivo or in silico, and a prerequisite for successful functional proteomics studies.
	Z705381	New and Emerging Proteomic Techniques	Leading researchers and innovators describe in step-by-step detail the latest techniques that promise to significantly impact the practice of proteomics, as well as its success in developing novel clinical agents. The methods span the entire spectrum of top-down and bottom-up approaches, including microarrays, gels, chromatography, and affinity separations, and address every aspect of the human proteome, both quantitatively and qualitatively. The techniques of protein detection utilized are diverse and range from fluorescence and resonance light scattering to surface plasmon resonance and mass spectrometry. The protocols follow the successful Methods in Molecular Biology™ series format.
	N6410	Novel Therapeutic Proteins: Selected Case Studies	This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins.
	Z700215	Peptide Arrays on Membrane Supports: Synthesis and Applications	Proteins interacting with diverse ligands - proteins, peptides or DNA - are the basic principles underlying many biological processes, such as antigen-antibody binding, signal transduction or receptor binding. The technique of oligopeptide synthesis on a cellulose membrane and the subsequent binding assays allow the investigation of protein interactions. A particular advantage of these peptide arrays (SPOT - technology) is the high number of oligopeptide probes that can be tested in parallel. Detailed protocols for peptide synthesis, and the analysis of protein-protein, protein-DNA interactions as well as epitope mapping are presented.
	Z704636	Posttranslational Modification of Proteins: Expanding Nature's Inventory	This book covers the wide range of posttranslational modifications found in Nature, many of which have been discovered relatively recently as a result of improved detection methods. It may be used as a reference or as a collection of the structural and functional variety of these modifications. The author covers the subject from the perspective of both the mechanism of formation of these protein conjugates and their biological function in processes like signal transduction and enzymatic catalysis. Several links are made between various modification processes and their roles in biological processes that tie together the heterogeneous collection of posttranslational modifications.
	P8742	Posttranslational Modification of Proteins: