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Z703761 G Protein Coupled Receptor-Protein Interactions This exciting volume elucidates how GPCRs organize signal transduction and control intracellular activities. Chapters written by the recognized expert in each respective topic offer state-of-the-art updates on the principles and technology, as well as stepwise protocols for methods currently applied to the analysis of protein-receptor interactions
Z704148 G Protein Coupled Receptors Handbook Authors describe the knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/ oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: role of GPCRs in mediating pain, development of receptor-type selective drugs based on the structural plasticity of receptor activation, and identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
Z379654 G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders Cutting-edge insights of leading basic and clinical investigators. The book combines critical overviews with detailed protocols for studying the involvement of G proteins and cellular signaling in psychiatric and neurological disease. The mental and neurological disorders covered range from Parkinson's disease and schizophrenia to manic depression, drug addiction, and mood and anxiety disorders.
M5565 G Protein Pathways Part B, G Proteins and their Regulators, Methods in Enzymology Vol 344 This volume covers topics such as the structure and identification of functional domains of G proteins, and activation of G proteins by receptors or other regulators. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modelling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume.
M5440 G Protein Pathways, Part A Receptors, Methods in Enzymology Vol 343 G Protein Pathways is the first of three volumes examining the nature of heterotrimeric G proteins. The text takes an integrated approach to studying common experimental questions at many different levels related to G proteins. Methods related to G proteins using molecular modeling, systems biology, protein engineering, protein biochemistry, cell biology, and physiology are all accessible in the same volume.
Z701416 G Protein Signaling: Methods and Protocols The involvement of G protein coupled systems in a range of biological processes in organisms from yeast to man has generated a large degree of interest. Due to the interdisciplinary nature of G protein coupled systems the types of techniques used to study their functions varies considerably. The methods contained in this text contain complementary biochemical, molecular biological and cell biological approaches to addressing questions so that they can be studied from multiple perspectives and adopted by different types of laboratories. These methods are of interest to scientists studying physiological roles of G protein systems, the signal transduction systems associated with these G proteins systems as well as the molecular nature of G proteins themselves.
G1540 G Protein-Coupled Receptors Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has utilized contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal microscopic methods and the search for endogenous ligands for orphan receptors.
G2415 G Proteins: Techniques of Analysis This book covers essential methods - with a commitment to those techniques of proven and current utility. This title includes expression and functional analysis of G proteins; evaluation of covalent modifications and other regulatory phenomena; and, mapping pathways established among receptors, G proteins, and effectors. Includes contributors from key institutions. Each author offers clear instructions to establish a synthesized, concise and consistent approach to each chapter, beneficial to all.
G3543 GTPase Protocols: The Ras Superfamily This is a collection of techniques to probe the function of these ubiquitous proteins both in vitro and in vivo. Each technique includes step-by-step instructions, tips on avoiding pitfalls and troubleshooting, and ancillary notes explaining how to adapt each procedure in the event of problems. The methods cover the spectrum of core techniques required for the five major GTPase subfamilies (Ras, Rho, Rab, Arf, and Ran) and permit a diversity of applications ranging from structural studies on a GTPase to real time in vivo analysis. This book illuminates the techniques used to study this family of proteins.
G9403 GTPases GTPases are proteins that act as molecular switches to control biochemical pathways within a cell. This book provides a complete guide to the properties and cellular roles of all the major families of GTPases, including the heterotrimeric G proteins and the small GTPases Ras, Rho, Rab, Arf and Ran. These proteins have caught the attention of those studying control of proliferation, differentiation, cell polarity, cell movement and vesicle and protein trafficking.
Z412546 Gardner’s chemical Synonyms and Trade Names, 11th ed. This essential reference contains some 35,000 entries, many of which have been added for the first time. Features a comprehensive selection of chemicals including bulk inorganic chemicals, major pesticides, dyestuffs, surfactants, metals, and alloys. Entries, whenever possible, contain detailed information on definitions, classifications, chemical composition, functions, applications, and suppliers. A feature new to this Edition is the inclusion of physical properties data for pure chemicals. Data that has been provided, as available, include the melting point, boiling point, density or specific gravity, refractive index, optical rotation, ultraviolet absorption, solubility, and acute toxicity.
Z528188 Gas Chromatography Simulation & Optimization Software Use GC-SOS to develop high efficiency capillary gas chromatography methods on your PC. This easy-to-use program provides an efficient and effective way to develop fully optimized GC methods. Off-line simulations can be rapidly and accurately performed to determine the effects of varying temperature, pressure, and/or column size conditions on your separations. Faster method development along with substantially improved separations can result in considerable cost savings along with increased run performance. Also serves as an invaluable tool for learning GC retention principles.
•Enter run conditions and retention data from actual data
•Import your chromatogram directly into GC-SOS
•Auto-Optimization feature finds an optimized set of run conditions for your separation
•Detailed printouts serve as a convenient method documentation tool
Z271756 Gas Chromatography, 2nd ed. This book presents an introduction to gas chromatography, including examples of applications. Shows readers malfunctions that can occur enabling them to recognize and fix faults.
Z651974 Gastrulation: From Cells to Embryo Gastrulation is the complex process of cell differentiation, following the division of a fertilised embryo, during which tissue layers are formed and the overall body plan is established. This book is the definitive guide to this vitally important period in embryonic development, providing authoritative and up to date information that includes the first comprehensive interspecies comparison, cell movements and patterning events, the roles of individual genes and gene families, and the evolution of gastrulation.
Z357413 Gel Electrophoresis: Essential Data Series This volume presents comprehensive data on gel electrophoresis of proteins, nucleic acids, nucleoproteins and carbohydrates. Also presented are sections on electrophoresis chemicals, types of apparatus, troubleshooting, and manufacturers and suppliers.
Z730351 Gene Cloning: Principles and Applications The ability to successfully clone genes underlies the majority of our knowledge in molecular and cellular biology. Existing textbooks describe what has been learnt from cloned genes but include little detail on how the cloning was achieved and how the techniques involved are carried out in the laboratory. Gene Cloning introduces the diverse array of techniques available to clone genes and how they can be used effectively both in the research laboratory, to gain knowledge about the gene, and for use in biotechnology, medicine, the pharmaceutical industry, and agriculture. It shows how cloning genes is an integral part of genomics and underlines its relevance in the post-genomic age, as a tool required to test predictions experimentally.
G2777 Gene Construction Kit Brochure Allows graphic manipulation of DNA Sequences and sophisticated plasmid drawing options. It has an award winning interface design that allows graphic manipulation of DNA sequences in addition to providing sophisticated drawing capabilities. GCK was named the "Best Plasmid Mapping Software" by the Biotechnology Software.
• Ideal for planning and tracking complex construction projects
• Manipulate actual DNA sequences through a unique and innovative graphical interface
• View construct either as a text sequence or graphically, linear or circular
• Automatically monitor and adjust DNA fragment ends during cutting and pasting
• Define thickness, pattern, shape, direction, and color for each DNA segment
• Search, download and import GenBank and EMBL files with all GenBank feature table items translated automatically into GCK features.
• Unique Chronography feature tracks the history of any given DNA segment and maintains alternative views
• Cut and paste DNA fragments from one construct to another (including segment history)
• View predicted electrophoresis patterns of restriction digests including partial digests
• Show DNA with protein sequence and/or with restriction enzyme or other sites of interest
• Create illustrations containing multiple constructs, gels, sequence listings, free text, legends and other graphics
• Create silent mutations to add or remove a restriction site from a sequence without changing the coding information
• Mark restriction sites using one or more completely editable and expandable enzyme lists
• Find Open Reading Frames using any codon table you specify
• Display the name of any region within the construct window
• Frame segments of DNA in the sequence display. Frames can encompass the site markers, sequence, and/or regions of a construct.
• Display and manipulate multiple constructs in the same illustration window

G0667 Gene Construction Kit For Windows Allows graphic manipulation of DNA Sequences and sophisticated plasmid drawing options. It has an award winning interface design that allows graphic manipulation of DNA sequences in addition to providing sophisticated drawing capabilities. GCK was named the "Best Plasmid Mapping Software" by the Biotechnology Software.
• Ideal for planning and tracking complex construction projects
• Manipulate actual DNA sequences through a unique and innovative graphical interface
• View construct either as a text sequence or graphically, linear or circular
• Automatically monitor and adjust DNA fragment ends during cutting and pasting
• Define thickness, pattern, shape, direction, and color for each DNA segment
• Search, download and import GenBank and EMBL files with all GenBank feature table items translated automatically into GCK features.
• Unique Chronography feature tracks the history of any given DNA segment and maintains alternative views
• Cut and paste DNA fragments from one construct to another (including segment history)
• View predicted electrophoresis patterns of restriction digests including partial digests
• Show DNA with protein sequence and/or with restriction enzyme or other sites of interest
• Create illustrations containing multiple constructs, gels, sequence listings, free text, legends and other graphics
• Create silent mutations to add or remove a restriction site from a sequence without changing the coding information
• Mark restriction sites using one or more completely editable and expandable enzyme lists
• Find Open Reading Frames using any codon table you specify
• Display the name of any region within the construct window
• Frame segments of DNA in the sequence display. Frames can encompass the site markers, sequence, and/or regions of a construct.
• Display and manipulate multiple constructs in the same illustration window

Z702358 Gene Expression Profiling: Methods and Protocols Leading scientists in gene expression methodology and bioinformatics data analysis describe readily reproducible methods for measuring RNA levels in cells and tissues. The techniques presented include new methods for applying the Affymetrix GeneChip, SAR-SAGE, StaRT-PCR, SSH, the Invader Assay, and ADGEM. The authors also provide critical bioinformatics insight and resources for data analysis and management. By distilling the basic underlying principles of many methods to a few straightforward concepts, investigators can easily choose the method most appropriate to their application
Z373974 Gene Isolation and Mapping Protocols: Methods in Molecular Biology, Vol. 68 A collection of the most up-to-date techniques for gene isolation and mapping, including the latest methods for gene characterization using data base analyses. Also, numerous time-saving techniques and informative explanations about certain steps are included.
G5916 Gene Knockout Protocols Highly skilled investigators in gene targeting and mouse genetics describe their best techniques for the design of targeting constructs and for the analysis of the mouse phenotype. These include embryo transplantation, in vitro embryonic stem cell differentiation, creation of aggregation chimeras, mouse pathology, embryo cryopreservation, and transplantation. State-of-the-art and highly practical, it constitutes an invaluable source of readily reproducible techniques for genetic researchers today.
Z730165 Gene Mapping, Discovery, and Expression: Method and Protocols A collection of cutting-edge computational tools and experimental techniques to study how genes are regulated, and to reconstruct the regulatory networks through which various cell-types are produced. On the computational side, web-based technologies to localize genes, to access and retrieve data from microarray databases, to conduct comparative genomics, and to discover the potential “codes” in genomic DNA that may control the expression of protein-coding genes. Detailed experimental techniques described include methods for studying chromatin structure and allele-specific gene expression, methods for high-throughput analysis to characterize the transcription factor binding elements, and methods for isolating and identifying proteins that interact with DNA.
Z306177 Gene Probes 1 Over 85 key protocols for the synthesis, labeling, detection, and quantification of DNA, RNA, oligodeoxynucleotide, and antibody probes are provided. It brings together key practical advice and step-by-step protocols for all of the major methods of probe labeling and detection.
Z306185 Gene Probes 2 Over 100 protocols for using DNA, RNA, oligodeoxynucleotide, and antibody probes in screening gene libraries, mapping, gene structure determination, analysis of gene expression, and mutational studies, are presented.
G1793 Gene Probes: Principles and Protocols Volume 179 of the Methods in Molecular Biology series contains an outstanding collection of time-tested protocols for designing and using genes probes in wide variety of applications. The applications covered range from searching for specific genes in the human chromosome to the detection of microorganisms and their toxins in the environment and in food samples, as well as in the diagnosis of human disease. Helpful tutorials explain the principles of gene probe design, labeling, detection, target formation, and hybridization conditions
Z730327 Gene Regulation 5th ed. Gene regulation is an essential process in the development and maintenance of a healthy body. This Fifth Edition provides a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview. For this edition, in addition to updating of existing material, sections on important methodologies have been expanded, and a new section included on regulation by small interfering RNAs. More detail has been added on the role of multi-protein complexes in transcriptional activation, and to the discussion of the regulation of transcription factor activity by specific modifications, to include acetylation and ubiquitination, as well as phosphorylation. The final chapter on gene regulation and human disease now includes additional novel examples, and a new section on the therapeutic potential of gene regulation.
Z340790 Gene Targeting: A Practical Approach, 2nd Edition This updated version includes the major new techniques and tried-and-tested practical protocols. It concentrates on gene targeting in mouse ES cells, but the techniques can be adapted to applications in tissue culture, including human cells.
G3918 Gene Therapy Protocols, 2nd ed. In this revised edition experts detail their most effective viral and nonviral methods of gene transfer, as well as discuss their applications in different organ systems. These methods range from those in which new molecular conjugates show great promise for targeting gene transfer and regulating transgene expression, to those used in such exciting applications as the delivery of therapeutic proteins, vaccination, and tissue engineering. This edition offers a compilation of the revolutionary advances that have recently occurred in gene transfer technology, with each article providing proven the step-by-step procedures that enable its successful therapeutic application.
G9291 Gene Therapy: Therapeutic Mechanisms and Strategies This reference covers all aspects of gene therapy, including viral and nonviral delivery systems, targeted diseases, regulatory issues, and FDA requirements. It investigates genetic bullets to block HIV-1 replication and genetic guns to deliver antiviral agents. It examines donor cells, vector systems, and functional genes; defines extra- and intracellular pathways and barriers for gene delivery; addresses the interaction of micelles and liposomes with nucleic acids; describes the formulations, pharmacology, and toxicology of oligonucleotides; considers RNA catalysis and decoy RNAs; and outlines hematopoietic stem cell procurement.
G8416 Gene Transfer Methods: Introducing DNA Into Living Cells and Organisms A critical aspect of the molecular revolution is that DNA frequently must be re-introduced into living cells to determine activity. The goal of this book is to compile a core set of numerous DNA transfer methods within a single volume. Chapters discuss DNA transfer into cells of bacterial, fungal, and mammalian origin, as well as into the germlines of flies, mice, and plants. Each chapter includes supplementary information such as common problems and specific troubleshooting suggestions. Progress and hurdles in the field of human gene therapy are presented.
Z703729 Gene Transfer to Animal Cells Gene transfer to animal cells was first achieved more than 30 years ago. Since then, transformation technology has developed rapidly, resulting in a multitude of techniques for cell transformation and the creation of transgenic animals. As with any expanding technology, it becomes difficult to keep track of all the developments and to find a concise and comprehensive source of information that explains all the underlying principles. This book describes the principles behind gene transfer technologies, how gene expression is controlled in animal cells and how advanced strategies can be used to add, exchange or delete sequences from animal genomes in a conditional manner. The final chapter provides an overview of all the applications of animal cell transformation.
Z730033 Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual Understanding gene function and regulation requires rigorous testing in live cells and organisms. Recent advances have provided a variety of new strategies for delivering DNA and RNA into cells and probing their expression, as well as new clinical applications that rely upon the introduction of genetic material. The vast number of available techniques for clinical and laboratory research often makes selecting the optimal method a difficult process. This book provides the first comprehensive guide to technical approaches for delivering nucleic acids into cells and organisms and of ensuring (even manipulating) appropriate expression. The detailed, step-by-step protocols include viral and nonviral methods of gene delivery, transgenic approaches, strategies for the regulation of transgene expression, and modification of the host response.
Z702617 Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 2nd ed. This edition offers current data on delivery systems and therapeutic strategies, gene expression and detection, and disease targets and therapeutic strategies. It presents results and prospects in gene therapy clinical trials, other cell-based therapies and trials, and regulatory issues. Topics include optimization of non-viral gene therapeutics, gene therapy for cancer, and DNA vaccines.
P5980 Gene cloning and analysis by RT-PCR This new laboratory protocols manual provides investigators with up-to-date RT-PCR based methods for gene cloning and analysis. Since RT-PCR was first described for the detection of low-abundance mRNAs, the method has been extended to quantitative measurements of relative and absolute levels of single and multiple mRNAs. Methods for obtaining RNA for RT-PCR have also been extended to include analysis of mRNA levels in clinical samples and even in single cells.
Z700991 Generation of cDNA Libraries:Methods and Protocols Expert researchers and inventors in the field describe their own proven techniques for generating cDNA/mRNA libraries to identify the functions of specific decoded gene sequences. A wide variety of techniques is presented for enhancing the generation of complete and full-length libraries, and for confirming the quality of the cDNAs generated. Among the applications detailed are electrophoresis, Northern blotting, single cell microarray analysis, subtractive hybridization, subtractive cloning, gene cloning, and peptide library generation. Each method includes background information, step-by-step instructions, a list of reagents, operational tips, and notes on instrumentation.
Z702420 Genes VIII Two decades ago Benjamin Lewin's Genes revolutionized the teaching of molecular biology and molecular genetics by introducing a unified approach to bacteria and higher organisms. Genes has remained at the cutting edge of molecular biology, covering gene structure, organization, and expression. Originally the text opened with the genetic code and worked toward genome structure. Genes VIII changed the approach to begin with the sequence of the human and other genomes and starts with complete coverage of recent advances in genomics. The coverage of genomics is then integrated throughout the text.
G6292 Genes and Signals: Imposing Specificity on Enzymes by Recruitment Many cellular functions require the orderly switching on and off of gene transcription, often in response to signals from other cells or the environment. This concise, attractively illustrated volume is a textbook on gene regulation and its importance in development and evolution. But the book also argues that understanding how transcription-related enzymes are controlled will reveal much about the regulation of enzymes in other biological processes as well.
Z700177 Genetic Library Construction and Screening This volume is designed to provide an easily accessible introduction to core strategies in the application of modern recombinant DNA technology. The first chapters directly address the applications of polymerase chain reaction to a variety of problems in DNA cloning th