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Z731196 MALDI MS: A Practical Guide to Instrumentation, Methods and Applications The introduction of the matrix-assisted laser desorption ionization technique (MALDI) changed mass spectrometry (MS) into a powerful tool for biomedical analysis that is now widely employed in academic as well as industrial laboratories. The 2002 Nobel Prize was awarded for the development of methods for identification and structure analyses of biological macromolecules. MALDI is one of the two mass spectrometric methods besides Electrospray which is universally used for this purpose.
Z701947 MAP Kinase Signaling Protocols A collection of techniques for the detection and measurement of mitogen-activated protein kinase (MAPK) signaling cascades. Protocols include methods for the determination of the subcellular localization of these components, structural and biophysical analysis of the components, and identification of novel components of known and unknown signaling cascades. Additional methods examine the upstream mechanisms of activation of MAPK cascades by various receptors, mechanisms involved in the down regulation of the MAPK cascades, and identification of targets of the MAPK cascades. It offers all the techniques needed in to conduct productive studies of MAPK signaling in health and disease, in measuring the influence of drugs, and in a broad range of experimental systems.
Z528277 MSDS Digital Filing Cabinet® Pro Priority support contract, 1 year 1 year priority support contract for Z52,826-9.
Provides a cost-effective solution to automating MSDS management. Easily scan, import, archive, search, track, view, print, and fax MSDS forms and all related documents. Import documents of all types from virtually any source. Use a scanner, fax, modem, keyboard, the Internet, or other programs to import documents into the digital filing cabinet. Works seamlessly with CISPro® inventory management software.
• Supports 3 hazard classification standards: NFPA, HMIS, and WHMIS (Canadian)
• Supports automatic document feed scanners for unattended scanning (typically 30s/page)
• Scan and store all support documents associated with a chemical (shipping manifests, receipts, batch records)
• Multi-level password protections for database access
• Automatic backup to local or network hard drive for added safety
• MSDS import wizard automatically imports electronic format MSDS from MSDS database systems, the Internet, and user-defined formats
• Built-in MSDS worksheet templates allow you to create simple MSDS forms
• Automatically generate update requests for out-of-date MSDS
Z702188 Macrolide Antibiotics: Chemistry, Biology and Practice, 2nd ed. This book explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. It discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treatment
M6185 Macrophages: A Practical Approach A variety of current techniques for the measurement of a broad range of macrophage activities have been brought together in one affordable volume. It provides succinct information on the isolation, activation and monitoring of diverse macrophage activities. Analysis of antigen processing and presentation, macrophage lytic functions, macrophage activity in vivo, and gene expression in mononuclear phagocytes are included.
Z547190 Magnetic Nanostructures Brings together all aspects of current research advances and emerging technologies on magnetic nanostructures for a wide range of readers. Covers a highly useful overview of specific topics related to nanostructured magnetic materials, their preparative methods, processing into nanoscale multilayers, thin films, particles, wires and dots, spectroscopic characterization, micro/nanostructures, physical properties, and potential industrial-oriented applications such as magnetic data storage, magnetic sensors, magnetic tunnel junctions, random access memories, spintronic divices, etc.
Z557730 Main Group Metals in Organic Synthesis, 2-volume set This is the first handbook to cover in detail all aspects of this fascinating field of chemistry. In two handy volumes, readers will instantly find the information they need, clearly structured according to the individual elements of the periodic table, hitherto only accessible after much time-consuming research. In short, a must for every organic chemist.
Z730378 Making and Using Antibodies: A Practical Handbook Written for professionals in the fields of biomedical research, this text uses a cookbook approach to presenting methods for the production, characterization, and use of antibodies. The book focuses on specific aspects of antibodies and takes readers on a step-by-step process from antigen preparation to immunizations, adjuvants, screening, purification, storage, and applications. Introductory material accompanies each chapter, giving readers a better understanding of the methods and applications. It covers basic techniques including enzyme-linked immunosorbent assay (ELISA), Western blotting, immunohistochemistry, and flow cytometry.
Z703176 Managing Scientists: Leadership Strategies in Scientific Research, 2nd ed. This updated edition provides managers with a practical guide focused on the particular management needs for research and development in biotechnology and pharmaceutical industries. It offers a way to improve the quality of interactions and creativity output in R&D, with real life case studies to illustrate key points.
Z700401 Manipulating the Mouse Embryo: A Laboratory Manual, 3rd ed. Regarded as the "Bible" of mammalian embryo manipulation techniques, the third edition has been completely reorganized and rewritten. The result is a compilation of new, cutting-edge protocols that include embryonic stem cell production and genetic manipulation, mouse chimeras, mouse cloning, assisted reproduction strategies (including intracytoplasmic sperm injection and in vitro fertilization), whole embryo culture systems, electroporation, embryo and gamete cryopreservation and rederivation, and gene expression, as well as more extensive background information on the use of these techniques.
Z379743 Manipulation and Expression of Recombinant DNA: A Laboratory Manual The techniques used in basic molecular biology research, presented as a series of tested protocols for students. Experiments are modular, allowing the instructor maximum flexibility for adapting to course curricula. The “project” approach give students an overview of an entire series of processes. Covers all important techniques and protocols, including some immunological techniques. Each lab session includes an introduction to the theoretical aspects of new techniques, references, and a list of materials used.
Z160059 Manipulation of Air-Sensitive Compounds, 2nd Ed. Revised to reflect the continuing and growing importance of research and development within this field, this second edition offers state-of-the-art methods used in handling air-sensitive compounds, including gases. Part One covers inert atmosphere techniques, while Part Two treats vacuum line techniques. Appendixes provide safety data, information on materials used to construct apparatus, and a table of vapor pressures of common volatile substances.
Z701300 Manual of Clinical Microbiology, 8th ed. Expanded into two volumes, "MCM" is the definitive resource for the microbiology, epidemiology, and clinical significance of all clinically significant bacteria, viruses, fungi, and parasites. No other single resource offers extensive, up-to-date information. It sets the standard for reliability and utility as a reference work. These volumes focus on the when and why of diagnostic procedures, as well as the how. It presents an approach to organizing information with thorough but concise treatments of all the major areas of microbiology, including new microbial discoveries, changing diagnostic methods, and emerging therapeutic challenges facing clinicians.
M0308 Manual of Immunological Methods The Manual of Immunological Methods presents validated assays that are accompanied by a series of tools that will guide readers in performing their own laboratory work. It covers specific methodologies including sample collection, preparation of cells, assay conditions, and data evaluation. Discussion of species differences and comparisons of a wide variety of species is an important feature. Both graduate students and practicing researchers in the areas of immunology and immunotoxicology will appreciate the Manual of Immunological Methods as a guide to standard operating procedures in the laboratory.
Z705950 March’s Advanced Organic Chemistry, 6th ed. The Sixth Edition clearly explains the theories and examples of organic chemistry, providing the most comprehensive textbook in organic chemistry available. Readers are guided on planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions. The Sixth Edition carries on the tradition of excellence with such new features as:
• More than 25,000 references to the literature to facilitate further research
• Revised mechanisms, where required, that explain concepts in clear modern terms
• Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries
• A revised Appendix B to facilitate correlating chapter sections with synthetic transformations

Z730025 Martindale: The Complete Drug Reference 35th ed. Martindale provides reliable, unbiased and evaluated information on drugs and medicines used throughout the world - no other source has the breadth and depth of coverage with 5,500 drug monographs; 128,000 preparations; 40,700 reference citations; 10,900 manufacturers
New for the thirty-fifth edition
• Now in 2 volumes and Chapters reorganized to better reflect the clinical use of drugs
• International Nonproprietary Names now in English, French, Latin, Russian and Spanish
• Increase in synonyms from Scandinavia, Baltic and Eastern European areas
• Increased coverage of 'street names' for drugs and substances liable to abuse
• Indication of drugs restricted or banned by sports authorities
• Molecular structural formulae included for selected drugs
• Coverage of proprietary preparations expanded to 36 countries, now including Czech Republic, Hungary, Russia and Venezuela
Z703052 Mass Spectra of Organic Compounds (SpecData) The collection contains 37,055 mass spectra of organic compounds. The data resulted from quality control in combinatorial synthesis and cover a wide range of structure classes. The compounds are applied for screening purposes in drug discovery. Additional information: Chemical structure ; Chemical name ; Molecular formula ; Molecular weight (Nominal mass) ; Base peak ; Reference ; Measurement condition
The software is available for Benchtop/SPC, Excalibur, Finnigan ICIS, Finnigan INCOS, Finnigan Ion-Trap, Finnigan Magnum, Finnigan GCQ, Finnigan SSQ, Finnigan TSQ, Finnigan ITS-40, Fisons VG Masslab, Fisons VG LabBase, Agilent Chemstation , NetCDF, NIST MSSEARCH, PE Turbomass, Shimadzu QP-5000, and Varian Saturn.
Z703060 Mass Spectra of Volatiles in Food (SpecData) 2nd ed. CD-ROM The Volatile Compounds in Food collection includes 1,620 reference mass spectra and covers the whole range of volatile compounds in food. Apart from the large number of natural, nature-identical and artificial flavours and aromas, there are, among others, food additives and solvents, pesticides and veterinary pharmaceutical compounds, which are frequently found as residues. Derivatives of non-volatile compounds such as sugars or polyhydroxyphenols are also available. A substantial number of the flavour and aroma compounds in this collection contain oxygen functional groups.

The following are frequently present: alcohols, ethers, aldehydes, ketones, acetals, ketals, acids and esters. Additional information: Chemical structure ; Chemical name ; Molecular formula ; Molecular weight (Nominal mass) ; Base peak ; Reference ; Measurement condition.
Z730211 Mass Spectrometry Data Analysis in Proteomics This book is a guide to analyzing raw mass spectrometry (MS) data in proteomics. As MS is a high throughput technique, proteomic researchers must attend carefully to the associated field of data analysis, and this volume outlines available bioinformatics programs, algorithms, and databases available for MS data analysis. Guidelines for data analysis using search engines such as Mascot, Xtandem, and VEMS are provided. Several different types of MS data are discussed, followed by a description of optimal methods for conversion of raw data into peak lists for input to search engines. Methods for assembling expressed sequence tags (ESTs) into assembled nonredundant databases are provided, along with protocols for further processing the sequences into a format suitable for MS data.
M6441 Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research In analyzing the effects of experimental drugs on the brain, mass spectrometry is the sole technique for identifying the presence and structure of neuropeptides–substances that indicate the effect of the drug. This book explains how to apply the technology to this process. It is written by mass spectrometry users, not mass spectrometrists, so the focus remains on practical applications. Readers will learn why mass spectrometry provides more outcome features than other techniques in neuropeptide analysis, including simultaneous detection, identification of substances present in mixtures, and sequence information even when the residues are modified, blocked, or unusual.
M6566 Mass Spectrometry in Cancer Research Cancer research is becoming multidisciplinary. Complex structural and therapeutic problems require synergistic approaches employing an assortment of biochemical manipulations, chromatographic or electrophoretic separations, sequencing strategies, and much more mass spectrometry. This book provides a broad examination of current strategies and techniques and their application to the study of occupational and environmental carcinogens; antineoplastic and chemopreventive agents; pertinent proteins, lipids, nucleic acids and glycoconjugates. Included is a chapter on instrumentation and methodologies.
M1066 Mass Spectrometry in Drug Discovery This reference summarizes the theory, instrumentation, and application of mass spectrometry and atmospheric pressure ionization to screen, evaluate, and improve the performance and quality of drug candidates. It covers: recent advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing; cassette dosing; the utilization of liquid chromatography/mass spectrometry (LC/MS) in chemical library characterization, combinatorial chemistry, drug transport, and in vivo microdialysis; reliable methods of sample preparation and handling; novel strategies to determine and characterize metabolite structures; the impact of absorption, distribution, metabolism, and elimination properties on drug discovery.
Z704695 Mass Spectrometry of Inorganic and Organometallic Compounds This is the first modern book to treat inorganic and organometallic mass spectrometry simultaneously. It is textbook and handbook in one; as a textbook it introduces the techniques and gives hints on how to apply the various techniques, as a handbook it lists all available ionization techniques for just about any given compound. The book also includes non-mathematical explanations of how modern MS instruments work
Z514284 Mass Spectrometry: Principles and Applications, 2nd ed. Presents a complete overview of the principles, theories and key applications of modern mass spectrometry. Extensively revised and updated, the second edition of this highly successful introductory textbook focuses on recent developments in techniques and applications. All instrumental aspects of mass spectrometry are clearly and concisely described, with tandem mass spectrometry introduced early on and then developed in more detail in its own chapter. Now includes greater coverage of ESI and MALDI, with biological and pharmaceutical applications described.
Z506176 Materials Handbook : A Concise Desktop Reference This book describes a comprehensive group of materials used in science and engineering with particular emphasis being placed on industrial materials. Detailed appendices provide additional information and an extensive bibliography completes this guide. The index and format of the book are designed to enable the reader to locate and extract relevant information quickly and easily.
Z514543 Matheson® Gas Data Book, 7th ed. This updated edition is a comprehensive and convenient compendium of scientific data on gases. It includes a full spectrum of properties for 157 gases with unique temperature-dependency graphs and other handy charts. Also provides practical advice on equipment and procedures, including valves, leak detection, disposal of leaking cylinders, transport, safety equipment, and first aid.
M1563 Matrix Metalloproteinase Protocols Experts detail proven laboratory techniques for the study of MMPs. Methods include those for the expression and purification of MMPs and TIMPs, for the detection of MMPs and TIMPs at both the protein and mRNA levels, and for the assay of MMP and TIMP activities in a variety of circumstances. Each method includes step-by-step instructions and notes variant applications and pitfalls to avoid. A selective overview of the MMP arena states where the field has been, where it is, and where it is going.
M7184 Matrix Metalloproteinases and TIMPs This book contains comprehensive data about matrix metalloproteinases (MMPs), enzymes which break down the extracellular matrix. It covers their sequences, three-dimensional structure, activation, substrates, specificity, inhibition, biological roles and function, along with protein sequence alignments. MMPs are regulated by their inhibitors (TIMPs). This volume contains sequences, three-dimensional structures and biological roles of TIMPs along with over 1700 references on MMPs and TIMPs.
Z553174 McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed. For more than a quarter of a century, this comprehensive dictionary has been a standard international reference. Containing more than 115,000 terms and 125,000 definitions--from 100 areas of science and technology--this trusted resource provides definitions written in clear, simple language, yet is consistent with the specialized use of the term. The sixth edition includes thoroughly revised with 5,000 new terms. Each term includes a helpful pronunciation guide. Entries are complemented by 3,000 illustrations; appendices containing biographic listings, conversion tables, taxonomic classification charts, and more.
Z730297 Measuring Gene Expression In the post-genomic age, much biomedical research looks at when, where, and at what level genes are expressed. Measuring Gene Expression is an all-in-one introduction to the main methods of measuring gene expression, including RT-PCR, differential display, RNA interference, reporter genes, microarrays, and proteomics, as well as a section on RNA isolation and analysis. There is an overview of each method: its pros and cons, sample preparation, sources of error, and data interpretation.
M9439 Mechanics of the Cell Biological physics, the application of physics to provide an understanding of biological phenomena, is a new burgeoning subject. This explores the physics behind the architecture of a cell's envelope and internal scaffolding, as well as the properties of its soft components. It discusses the properties of individual flexible polymers, networks and membranes, and then considers simple composite assemblages such as bacteria and synthetic cells. Analysis is performed within a consistent mathematical framework, although readers can navigate from the introductory material to biological applications without working through the intervening mathematics.
M9937 Mechanisms of Protein Folding, 2nd ed. Process by which polypeptide chains become their final 3-dimensional protein forms is clearly explained. Second edition incorporates significant improvements such as advances in interpreting observed kinetic data, development of technology to observe fast folding reactions, molten globule state, and vital role of chaperone proteins in protein folding. New discoveries of the central importance of protein folding and unfolding reactions in biology and medicine, including mutation and misfolding, are explored. Three case studies elucidate the difficulties of studying protein folding in vivo.
Z306290 Medical Virology: A Practical Approach Like other biomedical sciences, medical virology has undergone a revolution of diagnostic and scientific approaches through the advent of molecular biological techniques. Developing and maintaining an appropriate mixture of classical and molecular techniques for viral analysis is one of the challenges of medical virology today, and this volume addresses these issues. Topics covered include a broad description of "classical" techniques in viral diagnosis, nucleic acid detection by extraction and hybridization, use of the polymerase chain reaction, the application of various molecular techniques to aspects of the epidemiology of virus infections, and the principles and practical approaches to the analysis of viral evolution.
Z704709 Medicinal Chemistry of Bioactive Natural Products This book contains articles dealing with discovery, structure elucidation, and elegant synthetic strategies developed for natural products, with an emphasis on the structure activity relationship of bioactive natural products. The topics are selected carefully since bioactive natural products are clinically useful pharmaceuticals or the primary compounds under extensive medicinal chemistry exploration. The book provides examples with updated research results while also bringing a historical perspective to the chemistry and biology, a technique which could inform researchers about the process of developing pharmaceuticals, from discovery to application as drugs.
Z547948 Medicinal Chemistry: Principles and Practices, 2nd edition This book covers the key topics for drug discovery from the perspective of the practising industrial scientist and manager. Presenting all aspects of the subject from initial lead through to final development, this new edition builds on the highly successful foundations laid by the first edition by introducing new topics such as combinatorial chemistry, genomics and cheminformatics, alongside revised and updated original chapters.
Z700878 Medicinal Plants of the World, Volume 1: Chemical Constituents, Traditional and Modern Medicinal Uses, 2nd ed. Ross takes advantage of the growth in the amount of new data available to update and expand his first edition. This edition compiles new clinical research and references 26 widely used medicinal plants, including Allium sativum, Mangifera indica, Punica granatum;, Momoridica charantia, Mucuna pruriens; Arbus precatorius; Moringa pterysgosperma, Phyllanthus niruri, and Jatrpha curcas. Each chapter on a particular plant species contains: Common Names, Botanical Description, Origin and Distribution, Traditional Medicinal Uses, Chemical Constituents, and Pharmacological Activities and Clinical Trials.
Z731137 Medicines from Animal Cell Culture This book focuses on the use of animal cell culture, which has been used to produce human and veterinary vaccines, interferon, monoclonal antibodies and genetically engineered products such as tPA and erythropoietin. It also addresses the recent dramatic expansion in cell-based therapies, including the use of live cells for tissue regeneration and the culture of stem cells. It provides comprehensive descriptions of methods for cell culture and nutrition as well as the technologies for the preservation and characterization of both the cells and the derived products and describes the preparation of stem cells and others for use in cell-based therapies. The book includes experimental examples to indicate expected results and addresses the key issues of standardization and validation with chapters on GLP and GMP for cell culture processes
Z703613 Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine Cutting-edge articles review the current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.
Z364053 Membrane Protein Expression Systems: A User’s Guide This book is a simple-to-read laboratory manual describing the principles behind the commonly used expression systems, e.g. Escherichia coli, cell culture systems, Xenopus oocytes, baculovirus, vaccinia and yeast. Detailed experimental protocols for each system are provided in an easy-to-use, step-by-step format. The benefits of each system, as well as the likely pitfalls that newcomers might encounter, are discussed in each case.
Z701203 Membrane Protein Protocols: Expression, Purification, and Characterization A collection of key techniques for the study of receptors and transport proteins. The book provides examples of how different membrane proteins can be overexpressed in both prokaryotic and eukaryotic expression systems, how natural and overexpressed proteins can be solubilized from their host membranes, and how the solubilized protein can be purified in active form. Each protocols contains step-by-step instructions, troubleshooting advice, lists of reagents, and tips on avoiding pitfalls.
M4684 Membrane Transport: A Practical Approach This book will be of interest to those working on the mechanism of solute transport across biological membranes. Its scope is broad,