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Z703605 Oligonucleotide Synthesis: Methods and Applications A collection of powerful techniques for oligonucleotide synthesis and for use of modified oligonucleotides in biotechnology. Among the protocol highlights are a novel two-step process that yields a high purity, less costly, DNA, the synthesis of phosphorothioates using new sulfur transfer agents, the synthesis of LNA, peptide conjugation methods to improve cellular delivery and cell-specific targeting, and triple helix formation. The applications include using molecular beacons to monitor the PCR amplification process, nuclease footprinting to study the sequence-selective binding of small molecules of DNA, nucleic acid libraries, and the use of small interference RNA (siRNA) as an inhibitor of gene expression.
Z703656 Optimization in Drug Discovery: In Vitro Methods Researchers and experts from leading universities and major pharmaceutical companies systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort
Z369330 Organic Chemistry A modern, student-oriented introduction to organic structures, reactions and mechanisms. It maintains a modern approach in three ways: it extends organic reaction mechanisms into biological systems, it introduces spectroscopy early and integrates it throughout subsequent chapters, and it consistently reinforces stereochemical ideas throughout the text.
Z552291 Organic Chemistry Principles and Industrial Practice Nylon, Plexiglas, epoxy resin, and Elmer’s glue; dynamite, rubber tires, and spandex. These are a few among the multitude of industrial products produced using the principles of organic chemistry, principles that are often taught to students without reference to the commercial and practical importance of the subject. Written for students, and also giving much information that could be used to enhance teaching of the subject, the book, presented in ten concise chapters, combines important industrial processes with the principles of organic chemistry.
Z703257 Organic Chemistry of Biological Pathways This text provides a contemporary and authoritative treatment of the molecular logic of the chemistry of life. The authors have chosen to organize the text not by organic reaction type but by metabolic pathway. Doing so allows them to explain not only the chemistry of any given step but also the molecular logic of the entire pathway. Readers thus gain a deeper understanding of how and why the organic molecules of life undergo their sequential transformations and interconversions. To integrate the information from earlier chapters, as well as tie in traditional modes of organic reaction classification, the authors conclude with a summary chapter of the most common reaction types encountered in metabolism.
Z702390 Organic Chemistry of Drug Design and Drug Action, 2nd ed. Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate to many related classes of drug molecules. The second edition reflects the significant changes in the drug industry over the past decade, and now includes color illustrations, chapter problems, and other elements that make concepts easier to understand.
Z411620 Organic Chemistry of Drug Synthesis 6 Volume Set This series is a guide to virtually all syntheses used in the preparation of compounds given generic names.
Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
Z411612 Organic Chemistry of Drug Synthesis Volume 6 This series is a guide to virtually all syntheses used in the preparation of compounds given generic names.
Volume 6 covers the literature on the synthesis of medicinal agents from 1994 to 1998. This well-received series meets the needs of practitioners in the field who seek a quick overview of the synthetic routes that have been used to access specific classes of therapeutic agents. While most books on medicinal chemistry are organized on the basis of therapeutic or biochemical classes, materials in this series are arranged and discussed in terms of chemical structure. Thus, the preparation and detailed organic chemistry of the classes are presented in a unified way. Only drugs that have been granted a U.S. Adopted Name are included in this series.
Z537071 Organic Chemistry of Enzyme-Catalyzed Reactions, Revised 2nd ed. For those in organic and medicinal chemistry and biochemistry, this unique text focuses on the mechanisms of enzyme-catalyzed reactions. Following a general introduction to the role of enzymes as catalysts, each chapter describes the organic reaction mechanisms that are used by enzymes to catalyze a particular family of organic transformations. The compilation includes a vast number of drawings to illustrate structures and mechanisms, and focuses on one or two examples of enzymes that catalyze the particular chemistry for that transformation. Extensive references refer to the many experiments that have helped to elucidate enzyme mechanisms
Z412449 Organic Coatings: Science and Technology, 2nd ed. Now in one easily accessible volume, this second edition of a highly- successful desk reference presents a thoroughly-updated treatment of coatings technology and its numerous applications. Providing extensive references to sources of detailed information, Organic Coatings: Science and Technology, Second Edition helps scientists, engineers, and paint formulators in all branches of the coatings industry to better understand the principles underlying the technology, and use them effectively in the production and application of various types of coatings.
Z557528 Organic Reaction Mechanisms 1999 Surveys research on organic reaction mechanisms as described in the literature.
The 35th volume in this highly successful series is a guide to the most recent developments in organic chemistry with excellent references, author and subject references, and well respected editors with many years experience in the field
Z404950 Organic Reactions in Aqueous Media Rather than using hazardous substances, chemists are now looking to using water as a solvent in synthesis. This book provides readers with a general understanding of the current thinking in the field, from basic theory to synthetic application. It presents information necessary for designing efficient synthesis using water.
Z152099 Organic Reactions Volume 13 The volumes of Organic Reactions are collections of chapters each devoted to a single reaction, or a definite phase of a reaction, of wide applicability. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure, and the selection of experimental techniques. Numerous detailed procedures illustrate the significant modifications of each method. Includes tables that contain all possible examples of the reaction under consideration.
Presents critical discussions of widely used organic reactions from a preparative view point.
Z152102 Organic Reactions Volume 14 The volumes of Organic Reactions are collections of chapters each devoted to a single reaction, or a definite phase of a reaction, of wide applicability. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure, and the selection of experimental techniques. Numerous detailed procedures illustrate the significant modifications of each method. Includes tables that contain all possible examples of the reaction under consideration.
Presents critical discussions of widely used organic reactions from a preparative view point.
Z152110 Organic Reactions Volume 15 The volumes of Organic Reactions are collections of chapters each devoted to a single reaction, or a definite phase of a reaction, of wide applicability. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure, and the selection of experimental techniques. Numerous detailed procedures illustrate the significant modifications of each method. Includes tables that contain all possible examples of the reaction under consideration.
Presents critical discussions of widely used organic reactions from a preparative view point.
Z152269 Organic Reactions Volume 28 The volumes of Organic Reactions are collections of chapters each devoted to a single reaction, or a definite phase of a reaction, of wide applicability. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure, and the selection of experimental techniques. Numerous detailed procedures illustrate the significant modifications of each method. Includes tables that contain all possible examples of the reaction under consideration.
Presents critical discussions of widely used organic reactions from a preparative view point.
Z513199 Organic Reactions Volume 32 Presents critical discussions of widely used organic reactions from a preparative view point.
Intramolecular Diels-Alder Reaction
Z234311 Organic Reactions Volume 42 Birch Reduction Presents critical discussions of widely used organic reactions from a preparative view point.
Z243957 Organic Reactions Volume 43 Carbonyl Methylenation
Presents critical discussions of widely used organic reactions from a preparative view point.
Z410284 Organic Reactions Volume 52 Retro Diels Alder Reaction
Presents critical discussions of widely used organic reactions from a preparative view point.
Z528951 Organic Reactions Volume 56 Hydroformylation Reaction
Presents critical discussions of widely used organic reactions from a preparative view point.
Z528986 Organic Reactions Volume 58 Simmons-Smith Cyclopropanation Reaction
Presents critical discussions of widely used organic reactions from a preparative view point.
Z514276 Organic Reactions Volume 59 Presents critical discussions of widely used organic reactions from a preparative view point.
Z703672 Organic Reactions Volume 65 Presents critical discussions of widely used organic reactions from a preparative view point.
Z400947 Organic Syntheses via Boranes Vol. 1, H.C.Brown Reprint of H.C. Brown's 1975 title containing a detailed discussion of organoboranes in organic synthesis.
Z400955 Organic Syntheses via Boranes Vol. 2, H.C. Brown Provides an account of recent developments in organoborane chemistry. Topics include Hydroboration with Borane, and with Borane Derivatives, Organoborane Conversions to Functional Groups, and Carbon-Carbon Bond Formation via Organoboranes. Each survey chapter is followed by a chapter providing detailed experimental procedures.
Z514306 Organic Syntheses via Boranes: Volume 3 Suzuki Coupling In this volume various aspects of the Suzuki coupling reaction are discussed such as preparation of organoboranes for Suzuki coupling and coupling with Alkyl-, Alkenyl-, Alkynyl- and Arylboranes.
Z103535 Organic Syntheses, 2nd ed. Collective Volume 1 Volumes 1-9
Contains the procedures previously published in annual volumes 50-59, revised and updated where necessary. Efforts have been made to standardize the style of experimental procedures and the presentation of spectroscopic data. Increasing emphasis on the toxicology of organic compounds has led to the inclusion of additional hazard warnings, particularly for benzene, hexamethylphosphoric triamide (HMPA), and methyl iodide at the many places where they appear. Some experimental procedures have been improved, references have been added, and the index has been greatly expanded and simultaneously consolidated for efficient and easy use.
Z555711 Organic Syntheses, 2nd ed. Collective Volume 10 Organic Syntheses consists of protocols for the synthesis of useful chemical compounds. Each protocol is repeated in the laboratory of one of the editorial board members for accuracy or for missing experimental details prior to publication. For each protocol, safety warnings are presented along with detailed experimental descriptions for the preparation, purification, and identification of the compound. Additionally, special reaction conditions are detailed, along with the source of reagents, waste disposal information, a discussion of the results, references to the primary literature, and an appendix of nomenclature and registry numbers.
Z103543 Organic Syntheses, 2nd ed. Collective Volume 2 Volumes 10-19
Reflecting the increased pace of research and the many recent advances in organic chemistry, this series serves as a single-source compendium of the most up-to-date and significant procedures currently in use.
Z103551 Organic Syntheses, 2nd ed. Collective Volume 3 Volumes 20-29
Reflecting the increased pace of research and the many recent advances in organic chemistry, this series serves as a single-source compendium of the most up-to-date and significant procedures currently in use.
Z103578 Organic Syntheses, 2nd ed. Collective Volume 4 Volumes 30-39
Reflecting the increased pace of research and the many recent advances in organic chemistry, this series serves as a single-source compendium of the most up-to-date and significant procedures currently in use.
Z209031 Organic Syntheses, 2nd ed. Collective Volume 7 Volumes 60-64
Reflecting the increased pace of research and the many recent advances in organic chemistry, this series serves as a single-source compendium of the most up-to-date and significant procedures currently in use.
Z411655 Organic Syntheses, 2nd ed. Collective Volume 9 Reflecting the increased pace of research and the many recent advances in organic chemistry, this series serves as a single-source compendium of the most up-to-date and significant procedures currently in use.
Z547433 Organic Synthesis: Concepts and Methods, 3rd edition revised and enlarged The text has been enlarged to include new chapters on combinatoric chemistry, non-covalent molecular assemblies and the use of the Internet for searching chemical compounds. The authors have chosen the methods included here for their efficiency, elegance, and didactic value and have highlighted important reactions within the text.
Z730564 Organic Synthesis: State of the art 2003-2005 The first in a new series, this book provides chemists an effective, much-needed way to stay abreast of recent developments in organic synthesis. The 103 articles review the leading synthetic procedures developed from 2003 - 2005, discussing their significance and their applications. More than 100 reactions are covered, including Heterocycle Construction by Grubbs Metathesis, Enantioselective C-C Bond Construction, and Organic Reactions in Ionic Liquids.
Z514225 Organic-Chemical Drugs and Their Synonyms, 8th ed. For all scientists concerned with the development of new drugs, this standard work is well-known as "the Negwer". The 8th edition of the Negwer once again shows an impressive enlargement: Including more than 4.000 newly developed drugs, it now compiles more than 16.000 chemically unique drugs with more than 125.000 synonyms. The main part of the book (volumes 1-4) consists of the list of organo-chemical drugs arranged by increasing molecular formulas. The following items are given for each of the drugs included: molecular formula, CAS number, structure, references, synonyms, characterization and therapeutic use. The indices to facilitate working with the list are assembled in volumes 5 and 6: a group index (for finding drugs related to each other chemically or pharmacologically), the CAS number index, and the index of synonyms.
Z705799 Organometaliics 3rd ed. The original German version of this book is already a classic, and this comprehensive up-to-date English edition is THE organometallic textbook for all graduate students and lecturers of inorganic, organic, bioinorganic, coordination, and organometallic chemistry. This completely revised book has been expanded and updated to incorporate important developments in the field since the previous editions: the chapter on organometallic catalysis in synthesis and production appears for the first time in this form, bioorganometallic chemistry has considerably strengthened and a new section on the organometallic chemistry of the lanthanoids and actinoids has been added.
Z703931 Organometallic Chemistry of the Transition Metals, 4th ed. Fully updated and expanded to reflect recent advances, this Fourth Edition of the classic text provides students and professional chemists with an excellent introduction to the principles and general properties of organometallic compounds, as well as including practical information on reaction mechanisms and detailed descriptions of contemporary applications
Z422479 Organoselenium Chemistry: A Practical Approach Organoselenium chemistry has emerged as an important tool in the synthesis of complex organic molecules. This volume provides a hands-on survey of the most important techniques, complete with detailed procedures for the most useful transformations.
Z552321 Organosilicon Chemistry V: From Molecules to Materials Presents a comprehensive and detailed overview of the latest results in organosilicon chemistry. Contains synthesis and characterization of new organosilicon compounds, applications in polymer and materials science, and a summary of the latest research results.
Z251607 Oxford Chemistry Primers No. 14: Cluster Molecules of the p-Block Elements This concise text is the first to survey clusters of the elemental state (P4 and C60) as well as compounds, including boranes, cubanes, etc. The text is a balanced survey with worked examples. Graduate chemistry students working with main group and cluster chemistry courses will find it indispensable
Z233935 Oxford Chemistry Primers No. 2, Aromatic Heterocyclic Chemistry Focuses on synthetic aspects, rather than properties, and it covers the essential details and basic principles with reference to all the important classes of heterocyclic compounds. Instructional problems are included as an aid to comprehension, and references to more detailed texts are provided.
Z271454 Oxford Chemistry Primers No. 30: Process Development: Fine Chemicals From Grams to Kilograms Process development bridges the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. This concise and readable text uses real examples and case histories from ICI/Zeneca Pharmaceuticals to show the problems which may be encountered in scaling up chemical synthesis, and the ways these problems may be overcome. It shows how it is possible to synthesize multi-kilogram quantities of a new organic compound which has been made in the laboratory only in the milligram scale. A wide range of aliphatic, aromatic, and heterocyclic compounds is covered. This book will be invaluable both to the research chemist involved in the development phase of novel compounds, and the advanced undergraduate interested in the fine chemicals industry.
Z307939 Oxford Chemistry Primers No. 37: Introduction to Quantum Theory and Atomic Structure This book illuminates the basic concepts of quantum chemistry, and emphasizes atomic structure but not molecular applications. The author starts with a survey of the basic ideas and problems of wave/particle duality, the nature of wave function, and its statistical interpretation. He then discusses some important applications of Schrodinger's equation to chemically relevant situations, and probes the structure of the hydrogen atom, multiple-electron atoms and the periodic table of elements. The emphasis throughout is on the physical concepts and their concrete application.
Z307971 Oxford Chemistry Primers No. 41: Electrode Potentials Offering a comprehensive introduction to equilibrium electrochemistry, this primer deals with electrode potentials and their applications. It builds on a knowledge of elementary thermodynamics, informs the reader of the origin of electrode potentials, and shows how these are used to deduce a wealth of chemically important information such as equilibrium constants, free energy, enthalpy and entropy changes of chemical reactions, activity coefficients, and the selective sensing of ions. The emphasis throughout is on understanding the foundations of this discipline and how it may be used to study problems of chemical interest. The authors have minimized the mathematical aspects of the subject without any sacrifices in cla
Z307998 Oxford Chemistry Primers No. 42: Two-phase flow & heat transfer This concise and heavily illustrated book is exclusively concerned with gas-liquid two-phase flows. The first part deals with adiabatic flows, that is flows without the addition or removal of heat. Topics include flow pattern maps and homogenous flow. The second part covers heat-transfer in two-phase flows: boiling and condensation. It is concerned with issues like pressure drop flow, flooding, the drift flux model, and nucleation. The various types of heat transfer are identified and methods to calculate them are provided. Two-phase flow and heat transfer processes are commonly encountered in heat exchanges (distillation and condensation) and in pipelines. The book is intended for readers interested in chemical and mechanical engineering
Z402230 Oxford Chemistry Primers No. 50: Heat Transfer This primer follows a classical approach to the study of heat transfer with main chapters on conduction, forced convection, natural convection and radiation. Practical problems, however, do not normally divide neatly into purely conduction problems, purely forced convection and so on, although texts often assume this. To overcome this barrier, the author demonstrates in examples and problems that more than one aspect of heat transfer may be needed to solve a single practical problem. The book covers the essential material of a text twice its length, making it easier for the reader to find and understand key principles. It will be of particular interest to undergraduate students in engineering, especially in mechanical and chemical engineering, and to professional engineers working on heat transfer.
O8006 Oxford Handbook of Nucleic Acid Structure A comprehensive reference on all aspects of nucleic acid structure, with particular emphasis on results from x-ray crystallography and NMR studies. It describes in detail the variety of structural types discovered to date. It is set out in a systematic manner, progressing through the polymorphs of double helical DNA through to the higher order organizations of triplexes, quadruplexes and junctions, then to RNA structures in their various degrees of complexity.