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Image	Product #	Book Title	Description
	Z251917	Tactics Of Organic Synthesis	This reference emphasizes the tactical considerations needed to optimize synthetic results in the laboratory--an area most books neglect. Bringing together information that currently lies scattered throughout the literature, it approaches synthesis from a modern point of view. Ho presents both the general aspects of molecular assembly and important new reactions and reaction combinations. Includes over 500 flowcharts and illustrations that clearly demonstrate the subjects discussed.
	Z730645	Target Validation in Drug Discovery	This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book
	Z422444	Tartaric and Malic Acids in Synthesis: A Source Book of Building Blocks, Ligands, Auxiliaries, and Resolving Agents	Tartaric and malic acids are chiral (left- and right-handed) acids that occur in nature. Their derivatives are very useful as building blocks for synthesis of larger organic molecules. Such syntheses are extremely important in natural products research, the fine chemicals industry, and the pharmaceutical industry. This sourcebook offers concise, comprehensive reviews of the chemical properties and synthetic applications of all derivatives of tartaric and malic acids.
	Z553719	Techniques in Organic Chemistry	This manual is the most comprehensive and detailed presentation of lab techniques available written for organic chemistry students. Like no other techniques manual, it offers specific instructions for 3 different kinds of laboratory glassware (miniscale, standard-taper microscale, and Williamson microscale) plus extensive coverage of spectroscopic techniques, (NMR, IR, Mass Spectroscopy) and a strong emphasis on safety issues.
	Z374180	Techniques in Protein Chemistry VII	This bench-top reference highlights current methods for protein design and engineering, protein sequencing, protein folding, and amino acid analysis. Included in this book is information on mass spectral analysis of peptides and proteins and high-sensitivity protein and peptide separations.
	Z364444	Techniques in Protein Modification	Encyclopedic coverage of chemical methods for site-specific protein modification and methods for characterizing modified proteins. Appendices list commonly used reagents and preferred suppliers, and a discussion of general protein assay methods.
	Z369470	Telomeres	A comprehensive account of telomere structure and function in a variety of organisms including yeast, Drosophila, ciliates, plants and mammals is presented. Topics covered include: an historical overview, telomere dynamics, localization, transcriptional silencing and the significance of length regulation.
	T8448	Telomeres and Telomerase: Methods and Protocols	This book contains techniques for studying telomeres and telomerase. These reproducible methods provide cutting-edge tools to identify, measure, and analyze telomeres, to determine telomerase expression at the RNA level, to determine telomerase activity, and to detect potential modifiers of this activity. The techniques for assaying telomerase activity range from standard radiological TRAP assays to nonradioactive methods, from non PCR-based methods to techniques using real-time PCR. This book provides the array of techniques needed to develop telomerase inhibitors or telomerase markers.
	Z719129	Telomeres, 2nd ed.	An up-to-date survey of the current exciting state of telomere biology. Telomeres, specialized structures found at the ends of chromosomes, are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.
	Z704989	Ten Most Wanted Solutions in Protein Bioinformatics	The book considers the ten most significant problems for those looking to identify the biological properties and functional roles of proteins. Problem One considers the challenge involved with detecting the existence of an evolutionary relationship between proteins. Two and Three studies the detection of local similarities between protein sequences and analysis in order to determine functional assignment. Four, Five, and Six look at how the knowledge of the three-dimensional structures of proteins can be experimentally determined or inferred, and then exploited to understand the role of a protein. Seven and Eight explore how proteins interact with each other and with ligands. Nine moves us out of the realm of observation to discuss the possibility of designing completely new proteins tailored to specific tasks. Ten considers ways to modify the functional properties of proteins.
	Z700886	Textbook of Drug Design and Discovery, 3rd ed.	This edition has been thoroughly revised and updated to provide a complete source of information on all facets of drug design. The book follows drug design from the initial structure-activity relationship to the final processes of clinical evaluation and registration. Chapters investigate the design of drugs for particular cellular targets such as ion channels and receptors whilst others examine specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques and combinatorial approaches are also included.
	Z704946	Textbook of Medical Physiology, 11th ed.	Physiology's classic text continues to uphold its rich tradition -presenting key physiology concepts in a remarkably clear and engaging manner. This textbook covers all of the major systems in the human body, while emphasizing system interaction, homeostasis, and pathophysiology. This thoroughly updated, 11th Edition features a new full-color layout, short chapters, clinical vignettes, and shaded summary tables that allow for easy comprehension of the material. Elsevier titles with Student Consult will help you master difficult concepts and study more efficiently. Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. Each Student Consult title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.
	Z701971	Textbook of Receptor Pharmacology, 2nd ed.	In the bestselling first edition the innovative format united four major approaches to the study of receptors: molecular biology, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction systems. The second edition builds on this foundation. It streamlines the material and focuses on cell membrane receptors along with their immediate signal transducers. The section on the molecular structure of receptors reflects the advances in this area. This edition also includes two restructured new chapters, one on G-proteins and one on tyrosine kinases, as signal transductors.
	Z364223	The Telomere	Telomeres, specialized structures at the ends of chromosomes, are involved in genetic phenomena with a potential role in the aging and malignant transformation of cells. This book introduces the central questions concerning telomeres, examines experimental data, and provides a large number of recent references.
	Z273147	Theoretical & Physical Principles Of Organic Reactivity	This book covers the important topic of organic reactivity - how and why molecules react with each other - presenting both theory and applications. Places particular emphasis on valence bond theory.
	Z500003	Thin-Layer Chromatography	Emphasizes the general practices and instrumentation involving TLC and high performance TLC as well as their applications based on compound types, while providing a sound understanding of the underlying theory necessary for optimizing these techniques. Details novel qualitative and quantitative densitometric experiments on organic dyes, lipids, antibiotics, pharmaceuticals, organic acids, insecticides, and more! This latest edition also includes over 1,150 up-to-date references, new drawings of chromatograms, a glossary of important terms, and a list of supply and equipment sources.
	T8274	Thin-Layer Chromatography: Techniques of Chemistry, Vol. XIV, 2nd ed.	Written by the discoverer of modern day TLC, this volume remains one of the classics on this subject. It describes the aspects of TLC in two parts: Techniques and Applications.
	Z555479	Thiophenes	Contains a valuable distillation and critical evaluation of the Best Synthetic Methods for the formation and reaction of thiophenes (five membered heterocycles containing a ring sulfur) or polymers containing a thiophene functionality (thienyls). Emphasis is on describing efficient practical methods to effect the transformations described. The large number of experimental recipes enables the user to prepare a thiophene derivative without access to the original literature.
	Z730505	Times of Triumph, Times of Doubt: Science and the Battle for Public Trust	The intent and uses of science are a continuing preoccupation, especially in public debates on issues such as new pharmaceuticals, cloning, stem cells, genetically modified foods, and assisted reproduction. Times of Triumph, Times of Doubt, written by the eminent geneticist and historian Elof Carlson, explores the moral foundations of science and their role in these hot–button issues. Carlson chooses a variety of case histories and describes their scientific background and the part played by scientists in the application of their work, including their motivations and reactions to bad outcomes, both real and alleged. He examines why ethical lapses have occurred in these areas, why bad things happen when, for the most part, those who worked on the science had only good intentions in mind, and how such lapses can be prevented from occurring in the future.
	Z364282	Tissue Culture Techniques: An Introduction	A manual of tissue culture techniques for undergraduates in a first course; also useful to veteran culturists needing a quick review. Extensively illustrated, informal in style, complete with troubleshooting tips and problem sets.
	Z703907	Tissue Engineering: Essentials for Daily Laboratory Work	This practical book provides a fundamental insight into the complex world of tissue development and artificial cell culture using tissue engineering. The introductory chapters cover basic cell biology and cellular development as well as cell culture, with a main emphasis on ways of differentiating tissue and the critical evaluation of the properties of maturing tissue constructs. The authors also focus on the use of stem cells from the most varied sources in tissue engineering. The whole is rounded off by an exceptionally wide-ranging glossary containing some 1,000 key words from the fields of cell biology, cell culture development and tissue engineering.
	T8698	Transcription Factors	Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studing this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes, the factors involved in transcription and progresses to look at the regulatory systems which control this machinery both within the cell and also in the wider systems of the mammalian organism. Features include comprehensive review of an increasingly important subject area, a unique collection of all recent work, and covers both transcription factors and their control, and also both normal and disease states
	Z357553	Transcription Factors: A Practical Approach	Transcription factors are proteins that interact with specific DNA sequences to enable transcription to occur. This edition of a popular hands-on guide includes extensive updates and four new chapters, making it an ideal resource for standard techniques.
	T7442	Transcription Regulation in Prokaryotes	This provides a clear and concise summary of the flow of information from genes to proteins in simple prokaryotic cells. While most books cover transcription in a single chapter with a strong emphasis on eukaryotic transcription, this text is devoted to prokaryotic transcription and is perfect for molecular biology, microbiology, and technology courses. It includes a comparative chapter for parallel and divergent mechanisms in prokaryotic and eukaryotic transcription regulation
	T0698	Transgenesis Techniques: Principles and Protocols, 2nd ed.	This update presents techniques for generation and analysis of transgenic animals, with emphasis on manipulation of the mammalian genome. It concentrates on creation and maintenance of genetically modified murine strains, providing access to the germline by conventional pronuclear injection, and by retroviral and adenoviral infection. Emphasis is given to the generation, maintenance, and manipulation of embryonic stem cell lineages, with protocols for constitutive and conditional gene targeting. Chapters include techniques for cryopreservation of male and female germlines and for generation of transgenic sheep by nuclear transfer.
	Z700738	Transgenic Plants: Current Innovations and Future Trends	Recent major advances in transgenic plant technologies have generated a plethora of potential applications in agriculture and other areas (food safety, vaccine delivery etc). The authors review the current technologies as well as many of the potential applications. The book contains chapters on diverse topics, ranging from tree somatic embryogenesis, and chloroplast transformation, to in planta transformation. One feature is its focus on the future of transgenic plants. Site-specific recombination systems will certainly be part of that future as well as exciting applications such as edible vaccines and functional genomics.
	Z705764	Transgenic Plants: Methods and Protocols	A collection of readily reproducible techniques for the genetic transformation and regeneration of plants. The authors cover the most commonly used transformation systems for the regeneration of whole transgenic plants. Among the techniques discussed for the detection of transgenes are quantitative real-time PCR, RT-PCR, in situ hybridization, FISH, and TAIL-PCR. Risk assessment methods offer the opportunity to study Agrobacterium persistence in plant tissues and to investigate the possibility of transgene dispersal. Each protocol includes step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls
	Z507377	Transition Metal Reagents and Catalysts: Innovations in Organic Synthesis	Organometallic compounds of transition metals play a crucial role as reagents and catalysts in organic synthesis. Following up on Professor Tsuji's very well received 1991 volume, this state-of-the-art work provides complete coverage of transition metal reagents and catalysts from background theory to industrial applications.
	Z703451	Transition Metals for Organic Synthesis: Building Blocks and Fine Chemicals, 2nd ed.	Already in its second edition, here over 70 internationally renowned authors cover the vast range of possible applications for transition metals in industry as well as academia. This two-volume work presents the current state of research and applications in this economically and scientifically important area of organic synthesis as well as for the production of fine chemicals. Over 1,000 illustrations and the balanced presentation allow readers fast access to the thorough compilation of applications, making this an indispensable work for everyone working with such metals whether professionally or engaged in academic research.
	Z421804	Transition Metals in the Synthesis of Complex Organic Molecules, 2nd ed.	Written for organic chemists, this all-new second edition offers an easy entry into the field of organotransition metal chemistry without requiring a background in inorganic chemistry. The book first covers the basics of transition metal chemistry and gives a practical introduction to the mechanisms by which organometallic reactions occur. The organic chemistry of transition metals is then presented by class of metal complex, with many examples of applications in the synthesis of natural products, pharmaceuticals, polymers, and materials. Ideal for advanced undergraduate and graduate students as well as all practicing synthetic organic chemists.
	Z730106	Translational Control in Biology and Medicine	The new edition of this successful monograph has been both updated and broadened. Since the previous (second) edition was published in 2000, the structures of the bacterial and eukaryotic ribosomes have been published, advancing our basic understanding of translation and mechanisms involving protein and RNA regulators. In addition, as the title indicates, this edition has a new focus on the role of translational control in human development and disease. This book, with 30 chapters written by experts in the field, is essential reading for anyone interested in the process of translation, its regulation, and how its failure can be the cause of disease.
	Z705616	Transmembrane Signaling Protocols 2nd ed.	This fully updated and expanded second edition of Transmembrane Signaling Protocols demonstrates the use of such techniques as single cell imaging, bioluminecence resonance energy transfer, and global proteomics in the study of transmembrane signaling events. Highlights include the functional expression and genetic selection of mutant mammalian transmembrane receptors in yeast, real-time analysis of transmembrane receptor signaling in live cells, and bioluminescence energy transfer to monitor protein–protein interaction. Additional chapters use state-of-the-art methods to analyze gene expression and proteomic profiles related to transmembrane signaling events, as well as to genetically reconstitute bone marrow for the study of signal transduction ex vivo.
	Z702935	Trinucleotide Repeat Protocols	The protocols cover a variety of targets, ranging from DNA and RNA to proteins and whole animals, and focus not only on causal genes, but also on their affected products, such as transcription factors, neurotransmitter receptors, proteasomes, and mitochondria/oxidation damage. Experimental systems employed include E. coli, yeast, C. elegans, and mouse. Authors utilize a wide range of techniques, including gel electrophoresis, quantitative RT-PCR, immunological analysis, antibody usage and its applications, receptor assays using radioisotope handling, gene delivery by virus, brain cell and organotypic cultures, gender dependency, and neuron structure analysis.
	T3818	Troubleshooting HPLC Systems: A Bench Manual	This book provides a useful guide to the new generation of HPLC equipment and techniques. With emphasis on effective troubleshooting of HPLC systems, it covers system configuration and functions, problem-solving procedures, maintenance, and HPLC basics. It then guides users investigating the source of a malfunction through each system component-from solvents and reservoirs to sample preparation to columns and detectors. Special features include a detailed review of HPLC instrumentation and accessories, role of operating parameters as indicators of system performance, and tables and charts detailing solvents' properties.
	Z224014	Troubleshooting LC Systems	Provides all the fundamental principles of LC operation, including a microscopic description of all the elements of LC devices. This book is an essential laboratory handbook--one that empowers expert and novice chromatographer alike to solve every sort of practical laboratory problem on a day-to-day basis.
	Z731269	Troubleshooting and Maintenance Guide for Gas Chromatographers 4th revised ed.	This fourth edition of the classic guide for every user of gas chromatographic instrumentation is now updated to include such new topics as fast GC using narrow, short columns, electronic pressure control, and basic aspects of quantitative gas chromatography. The author shares his many years of experience in technical support for gas chromatography users, addressing the most common problems, questions and misconceptions in capillary gas chromatography. He structures and presents the material in a concise and practical manner.
	Z702498	Tumor Necrosis Factor: Methods and Protocols	A comprehensive collection of readily reproducible techniques for TNF production, characterization, mutagenesis, and detection in biological specimens. Also included are several in vitro assays and animal models for studying the role of TNF in various TNF-related diseases and in cancer. The collection offers molecular and cellular biologists, pharmacologists, and toxicologists a diverse set of versatile, cutting-edge tools for illuminating the pathophysiological roles of TNF in disease and for identifying new drugs.
	T0191	Tyrosine Phosphoprotein Phosphatases, Second Edition	This edition provides a practical and accessible guide to this major family of proteins with particularly important insights into their molecular biology, biochemistry, and role in cellular physiology. Topics include the sequence, structure, and biochemical properties of PTPases, regulation of PTPase expression, substrate preferences and catalytic mechanisms, physiology, covalent modification, modification by chemical agents and proteolysis, and interactions with other proteins, peptides, and macromolecules. Featuring comprehensive coverage of the subject, including an extensive bibliography, this volume will provide an important resource for researchers and graduate students in molecular biology and biochemistry
	T2442	T Cell Protocols	A compilation of step-by-step techniques for the study of T cell developmental biology and their subsequent activation. It includes treatment of both fundamental and novel experimental protocols for the analysis of the role T cells play in immune function and in the prevention and cure of human diseases.

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