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DNA Modification / Repair

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Image	Description	Biochem/physiol Actions	CAS Number	Product #
	6,7-Dihydroxycoumarin 98%		305-01-1	246573
	Bleomycin sulfate from Streptomyces verticillus crystalline, 1.5-2.0 units/mg solid	An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.	9041-93-4	B5507
	Carboplatin	Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.	41575-94-4	C2538
	Carmustine ≥98%	DNA alkylating agent causing DNA interstrand crosslinks.¹ Effective against glioma and other solid tumors.	154-93-8	C0400
	Chlorambucil	Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. Death of chronic lymphocytic leukemia cells occurs via a p53-dependent mechanism.	305-03-3	C0253
	Cyclophosphamide monohydrate ISOPAC^®	Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.	6055-19-2	C7397
	Dacarbazine	Dacarbazine is a triazine anticancer agent that generates methyl adducts to purine bases in DNA.	4342-03-4	D2390
	Ifosfamide ≥98%	Ifosfamide is a nitrogen mustard compound that is a structural isomer of cyclophosphamide. Ifosfamide is a prodrug that must be transformed by cytochrome P450 to the biologically active component. It is used as an antineoplastic agent in cancer chemotherapy, but ifosfamide is more likely to cause renal toxicity than cyclophosphamide.	3778-73-2	I4909
	Lomustine ≥98%	Antineoplastic agent with cellular DNA effects.^1,^2,³ Lomustine induces p53 expression in A2870 cells.⁴	13010-47-4	L5918
	Melphalan powder	Antineoplastic agent.^1,² It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences.³	148-82-3	M2011
	Mitomycin C from Streptomyces caespitosus powder	Inhibitor of DNA synthesis, nuclear division, and cancer cells. Antibacterial to gram positive, gram negative, acid-fast bacilli.	50-07-7	M0503
	Mitoxantrone dihydrochloride ≥97% (HPLC)	Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis..	70476-82-3	M6545
	Oxaliplatin solid	Anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA.	61825-94-3	O9512
	cis-Diammineplatinum(II) dichloride crystalline	Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca²⁺/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.	15663-27-1	P4394

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