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DNA-RNA Transcription Regulators

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Biochem/physiol Actions
CAS Number
Product #
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.
 53-85-0 D1916
Actinomycin D from Streptomyces sp., ~98% (HPLC) An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
 50-76-0 A1410
Doxorubicin hydrochloride ≥98% (TLC) Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA;1 Properties.2,3
Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
 25316-40-9 D1515
Homoharringtonine Cytotoxic alkaloid from the evergreen tree, Cephalotaxus hainanensis. Binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. Blocks progression of leukemic cells from G1 phase into S phase and from G2 phase into M phase.
 26833-87-4 H0635
Idarubicin hydrochloride solid Topoisomerase II inhibitor
 57852-57-0 I1656

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