Order Center

HSP-90 Inhibitors

Reset Table

Image	Description	Biochem/physiol Actions	CAS Number	Product #
	17-(Allylamino)-17-demethoxygeldanamycin ≥98% (HPLC), solid	Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185^erB2.	75747-14-7	A8476
	Geldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder	Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.	30562-34-6	G3381
	Rifabutin >98% (HPLC), solid	Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.	72559-06-9	R3530

Copyrights © 2008 Sigma-Aldrich Co. All Rights Reserved. Reproduction of any materials from the site is strictly forbidden without permission. Sigma-Aldrich brand products are sold exclusively through Sigma-Aldrich, Inc.