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Therapy Adjuncts

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Image	Description	Biochem/physiol Actions	CAS Number	Product #
	(−)-Scopolamine hydrobromide trihydrate ≥98% (TLC), powder	Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.	114-49-8	S1875
	4-Amino-1,8-naphthalimide	Sensitizes cells to radiation-induced cell damage and enhances the cytotoxicity of 1-methyl-3-nitro-1-nitrosoguanidine.	1742-95-6	A0966
	Amifostine ≥97% (TLC), powder	Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.	20537-88-6	A5922
	Brefeldin A from Penicillium brefeldianum, ≥99% (HPLC and TLC)	Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.	20350-15-6	B7651
	Cimetidine	H₂ histamine receptor antagonist; I₁ imidazoline receptor agonist; anti-ulcer agent. Blocks cancer metastasis by inhibiting the expression of E-selectin on the surface of endothelial cells, thus blocking tumor cell adhesion.	51481-61-9	C4522
	Lectin from Viscum album (European mistletoe) lyophilized powder	VAA is not blood group specific, but has an affinity for terminal β-D-galactosyl residues.¹ VAA inhibits protein synthesis similarly to Ricin (RCA₆₀) and inhibits allergen induced histamine release in vitro from human leukocytes.²		L2662
	Leuprolide acetate salt ≥98% (HPLC)	Luteinizing hormone releasing hormone (LH-RH) agonist.	74381-53-6	L0399
	Luteinizing hormone releasing hormone human acetate salt ≥98% (HPLC), powder	Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.	71447-49-9	L7134
	Papaverine hydrochloride powder	Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.	61-25-6	P3510
	Phosphomycin disodium salt	Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis.	26016-99-9	P5396
	Pifithrin-α ≥95% (HPLC), powder	Pifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin, etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Pifithrin-α protects mice from lethal whole body γ-irradiation without an increase in cancer incidence. The protective effect is not seen in p53-null mice or cells expressing a dominant negative mutant of the p53 gene. Protection is conferred by the transient expression of p53 in p53-deficient cell lines.	63208-82-2	P4359
	Thapsigargin ≥90% (HPLC), liquid or film	Potent, cell-permeable, IP₃-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca²⁺ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca²⁺ levels; incorporated into chemotherapeutic prodrug formulations.	67526-95-8	T9033
	[D-Lys⁶]-LH-RH ≥95% (HPLC), powder	LH-RH agonist. It has been conjugated to cytotoxic compounds such as methotrexate (MTX), doxorubicin (DOX), and glutaryl-2-(hydroxymethyl)anthraquinone (G-HMAQ), and together with other conjugated LH-RH analogs comprise a class of targeted chemotherapeutic agents for cancers expressing receptors for LH-RH.	52671-12-2	L5022
	[D-Trp⁶]-LH-RH ≥97% (HPLC), powder	Potent LH-RH agonist with enhanced biological activity due to its slower rate of degradation. Like [D-Lys⁶]-LH-RH, the D-Trp⁶ analog has been shown to be effective against cancers expressing the LH-RH receptor. However, unlike the D-Lys⁶ analog, it is generally used in the unconjugated form.	57773-63-4	L9761

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