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Image	Product #	Book Title	Description
	K4637	Kinesin Protocols	Kinesin-like proteins (KLP) are thought to be responsible for transport of cellular cargoes and involved in many cellular processes. This book presents reproducible techniques for identification, purification, and characterization of the kinesin superfamily of microtubule-dependent motors. Methods include step-by-step instructions and cautionary notes. Considered are methods to express and purify kinesins in different systems, to characterize microtubule-enhanced ATPase activity and motility properties, and to test microtubule destabilizing activity.
	Z705594	LC/MS - A Practical User’s Guide	This book is a hands-on reference that focuses on the practical applications and techniques needed to use LC/MS successfully. The author presents empirical methods for optimizing the techniques, maintaining the instrumentation, and choosing the appropriate MS or LC/MS analyzer. It covers everything users need to know about the latest equipment, including quadrupole, time-of-flight, and ion trap analyzers; cutting-edge processes, such as preparing HPLC mobile phases and samples; handling and maintaining a wide variety of silica, zirconium, and polymeric separation columns; interpreting and quantifying mass spectral data; and using MS interfaces; current and future applications in the pharmaceutical and agrochemical industries, biotechnology, clinical research, environmental studies, and forensics An accompanying PowerPoint® slide-set on CD-ROM provides vital teaching tools for instructors and new equipment operators.
	Z719048	Lab Dynamics: Management Skills for Scientists	Scientists are trained in scholarship and technical skills but not, typically, in how to deal with their peers, supervisors, or staff who report to them. Yet even a first-rate research project can fail or flounder if the people concerned can't get along. Lab Dynamics is a book about the challenges of doing science and dealing with the individuals involved, including oneself. The authors, a scientist and a psychotherapist, draw on principles of group and behavioral psychology but speak to scientists in their own language. They offer in-depth, practical advice, real-life examples, and exercises tailored to scientific and technical workplaces on topics as diverse as conflict resolution, negotiation, dealing with supervision, working with competing peers, and making transitions between academia and industry.
	Z701149	Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench	Work at the biology bench requires a knowledge of mathematical methods and formulae. This book is a compilation of the mathematical concepts and methods in molecular biology, and provides guidance on their application to research investigations. Subjects range from basics such as scientific notation and measuring and making solutions, to more complex activities like quantifying and designing nucleic acids and analyzing protein activity. A reference section features useful tables, conversion charts and "plug and chug" equations for experimental procedures. This volume is a structured source of information that in many laboratories is scattered.
	Z730092	Lab Ref, Volume 2: A Handbook of Recipes, Reagents, and other Reference Tools for Use at the Bench	This book is a handy benchtop source of recipes and information needed for common laboratory protocols. Volume 2 contains recipes for procedures as diverse as RNA interference, imaging, proteomics, and quantitative nucleic acid analysis, and is organized by application for quick and easy reference. All recipes were derived from recent manuals published by Cold Spring Harbor Laboratory Press, and each recipe is cross-referenced to its manual of origin. Reference tables and charts are included. To meet the growing need for computational resources in the biology laboratory, this book also has an expanded Web site section with sources for biological materials, databases for acquiring and annotating genomic and proteomic data, and links to downloadable software.
	L2415	Lab Ref: A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench	This handbook of valuable information extracted from laboratory manuals published by Cold Spring Harbor Laboratory Press is presented in an easy-to-use format. It contains invaluable reference data, never before assembled in one handy package. It has been assembled from extensively field-tested manuals, ensuring accuracy and reliability, by two scientists with extensive and diverse experience of laboratory practice.
	Z730475	Laboratory Companion: A Practical Guide to Materials, Equipment and Techniques, Revised ed.	From vacuum technology and glass vacuum systems to volumetric glassware, gas-oxygen torches, and cryogenic tanks, The Laboratory Companion provides complete coverage of all commonly used lab equipment, including essential information about its selection, use, cleaning, and maintenance. It clearly explains the historical development and rationale behind how and why things are done in the lab, and includes helpful guidelines and step-by-step procedures for each topic discussed. Since glassware is typically the most prevalent type of lab equipment, much of the book is devoted to the properties and handling of glass apparatus, with additional material on rubber and plastic tubing, corks, stoppers, and O-rings. Readers will also find broad coverage of measurement systems, high- and low-temperature apparatus and techniques, compressed gases, vacuum systems, and other essential subjects.
	Z373826	Laboratory Guide to RNA	This guide provides detailed accounts of experimental procedures ranging from the isolation, analysis, and quantification of RNA from a variety of sources to large and small scale synthesis of RNA. Protocols such as RNA blotting, nuclease protection, and in situ hybridization are covered. A solid reference on the analysis of gene expression at the RNA level.
	Z553409	Laboratory Quality Assurance System: A Manual of Quality Procedures and Forms with CD, 3^rd ed.	Incorporates changes to ANSI/ISO/ASQ 9001-2000 pertaining to laboratories and provides information on the inter-relationship of ANSI/ISO 17025:1999 and ANSI/ISO/ASQ. Also provides blank forms used in preparing a quality manual.
	L0911	Laboratory Test Handbook, 5th ed.	Most of the routine and many of the more specialized analyses available from today's clinical laboratory are encapsulated in this handbook. Information about each laboratory procedure is presented in a standardized monograph format and includes test name, synonyms, patient care, specimen requirements, reference ranges, and interpretive information with footnotes and references. Over 900 laboratory tests are detailed and each entry is complete in itself.
	Z730262	Lange’s Handbook of Chemistry 70th anniversary edition	A standard reference for chemists for 70 years, this new Sixteenth Edition features an enormous compilation of facts, data, tabular material, and experimental findings in every area of chemistry.Included in this massive compendium are listings of the properties of approximately 4,400 organic and 1,400 inorganic compounds. This Sixteenth Edition offers 40% new or extensively revised content and starting with this edition, the author includes equations that allow users to calculate important values such as temperature and pressure. The handbook very chemist must have.
	L7289	Lateral DNA Transfer: Mechanisms and Consequences	This book is about mobile genes - the transfer of DNA between unrelated cells. It discusses the machinery of gene transfer and its wide-ranging biological and health consequences. Mobile DNA makes possible the development of antibiotic resistance in microbes, the conversion of harmless to pathogenic bacteria, and the triggering of cancerous growth in cells. It also contributes to human evolution.
	Z378216	Lectin Methods and Protocols	A collection of methods for applying lectins in biomedical research. The techniques are optimized by the researchers who developed them, and are presented in an easy-to-use format. Features include powerful methods for studying structure and function of glycoproteins, detecting altered glycosylation, lectin blotting, and applications to living cells. An appendix lists specifications and properties for all lectins discussed.
	Z703915	Lehninger Principles of Biochemistry, 4th ed.	The Fourth edition presents the fundamentals of biochemistry through selected topics, incorporating the most important recent developments and applications into its singular presentation of the field's classic core. For the new edition, authors David Nelson and Michael Cox offer groundbreaking new treatment of metabolic regulation, up-to-date coverage of DNA-based information technologies, and many new medically relevant applications. Also new is an innovative graphical style for depicting enzyme reaction mechanisms, step by step. While incorporating this essential information, the new edition has been streamlined to be 10% shorter.
	Z704466	Lentivirus Gene Engineering Protocols	Authors detail all the theoretical and practical aspects of lentivirus vector-based gene transfer. They demonstrate lentivirus vector production with methods for recovering appropriate producer cells, for producing and titrating lentivirus-containing supernatants, and for detecting transduced cells. The applications of lentivirus vector engineering to different cell types include coverage of lymphocytes, dendritic cells, hematopoietic stem and progenitor cells, mesenchymal stem cells, hippocampal neurons, cardiomyocytes, as well as airway epithelia, corneal cells, and retinal pigment. Also advanced are applications in which genetic material is directly inoculated with lentivirus vectors in such experimental animal models as mouse, rat, and rabbit.
	Z350311	Leucocyte Antigen: FactsBook, 2nd ed.	This book contains over 130 entries on molecules specifically expressed on the surface of cells of the haematopoietic system including characterized CD antigens, antigen receptors, MHC antigens, adhesion molecules, and cytokine receptors.
	Z422487	Lewis Acid Reagents: A Practical Approach	A laboratory manual providing step-by-step protocols for using Lewis acid reagents to catalyze organic synthesis processes. Discusses a variety of new selective organic syntheses that are now available using modified/designed reagents.
	Z511722	Lewis Acids in Organic Synthesis, 2-Volume Set	Provides an in-depth treatment of the characteristics, benefits and limitations of each class of acid and discusses reactions catalyzed by Lewis acids. Organized according to the central atom of the Lewis acid rather than by reaction type. Includes extensive cross-referencing and a comprehensive index.
	Z731234	Ligand Design for G Protein Coupled Receptors	G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design. Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs.
	Z558494	Lipases and Phospholipases in Drug Development	Lipases and phospholipases are key control elements in mammalian intermediary metabolism. They share many common features that set them apart from other metabolic enzyme classes, most importantly their association with "two-dimensional" substrates. Their potential as drug targets for the treatment of metabolic diseases is increasingly recognized, and the first lipase inhibitor drugs have been successfully introduced.
	Z700959	Liposomes 2nd ed., A Practical Approach	This edition contains significantly updated chapters from the 1st edition and several new chapters. The first half of the book addresses a number of essential experimental protocols such as the preparation, characterization, and storage of liposomes. Also included are methods for drug encapsulation into liposomes, modification of the liposomal surface to control drug behavior in biological environments, long-circulating liposomes and the use of cationic liposomes as transfection vectors. The second half discusses specific areas of liposome research and application, such as pH-sensitive liposomes, liposomes for diagnostic imaging, liposomal DNA vaccines, isothermic titration calorimetry of liposomes and vesicular phospholipids gels.
	Z378143	Liposomes in Gene Delivery	Pharmacologists are familiar with liposomal drug delivery systems, and molecular biologists are comfortable with the concepts of genetic manipulation with DNA vectors. Gene delivery with liposomes is where the twain meet, and this volume aims to clarify the interface. An introductory text for nonviral gene therapy, it uses clear explanations and illustrations to prepare readers to perform well designed experiments with appropriate controls.
	Z702080	Liquid Chromatography - Mass Spectrometry: an introduction	With the advent of new interfacing technology, the benefits of LC-MS (liquid chromatography with mass spectrometry), are being realized by the growth in applications of this technique in both the chemical and life sciences. Topics covered include: Limitations of the component techniques when used in isolation, and how a combination of the two allows these to be overcome; Descriptions of the various approaches, including thermospray, electrospray and atmospheric pressure chemical ionization, which are used to interface the two techniques, along with the advantages and disadvantages of each system; Illustrative examples of the applications of LC-MS, including the molecular weight and structure determinations of both biopolymers and low-molecular-compounds.
	Z652024	Live Cell Imaging: A Laboratory Manual	Recent advances in imaging technology reveal, in real time and great detail, critical changes in living cells and organisms. This manual is a compendium of emerging techniques, organized into two parts: specific methods such as fluorescent labeling, and delivery and detection of labeled molecules in cells; and experimental approaches ranging from the detection of single molecules to the study of dynamic processes in organelles, organs, and whole animals. Although presented primarily as a laboratory manual, the book includes introductory and background material and could be used as a textbook in advanced courses. It also includes a CD containing movies of living cells in action, created by investigators using the imaging techniques discussed in the book.
	Z271748	Logic Of Chemical Synthesis 2nd ed.	This book provides a detailed description of the general principles and strategies for solving chemical synthesis problems of complex organic molecules. It is the only book to deal systematically with the fundamental principles of synthetic problem solving.
	L6663	Low-Cost Approach to PCR: Appropriate Transfer of Biomolecular Techniques	Despite the large impact of PCR, many applications remain within the confines of research and academic environment. Dr. Harris makes this technique accessible to researchers, physicians, and laboratory workers throughout the world. It provides practical details of the method, and technology transfer program that she developed. It serves as a guide for those with limited budgets, such as potential users in developing countries, those wishing to work abroad or in undergraduate labs. Specific applications are immediately useful to study of infectious diseases.
	L3165	Luminescence Biotechnology: Instruments and Applications	The dangers inherent in radioactivity-based methods have caused a shift towards luminescence measurements and visualization techniques. This up-to-date review covers the fundamentals of different luminescence-based assay systems, calculation methods, and instruments through the spectrum of applications and research advances. Topics include gene and protein assays, oxidative stress and tissue aging, applications of luminescent microspheres, and proton image analysis. This book clearly identifies the advantages of luminescence over other assay techniques, discusses its potential pitfalls, and illustrates the broad range of its utility.
	Z340766	Lymphocytes: A Practical Approach	Straight-forward protocols on preparation and identification of lymphocytes, immortalization, cell and organ culture, and quantification assays are contained in this book. It also covers advances such as the use of the gamma-interferon ELISpot assay and peptide-HLA tetrameric assay to quantify antigen-specific T-cells directly from peripheral blood, without the need for in vitro culture, and molecular methods for accurate HLA typing.

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