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Image	Product #	Book Title	Description
	S2439	SNP and Microsatellite Genotyping: Markers for Genetic Analysis	Scientists are working to determine the genetic basis of disease. The aim of this book is to provide a reference manual to guide researchers in study design, selection of genetic markers (SNPs and microsatellites), genotyping methodologies, and basic analysis techniques. Topics covered include cytokine and cytokine receptor polymorphisms, high throughput analysis of SNP markers, new polymorphic microsatellite markers, large-scale genetic studies, DNA pooling strategy, linkage and association, and SNPs in gene mapping and DNA chip-based technologies (SNP Arrays).
	S2564	SV40 Protocols	Volume 165 of the Methods in Molecular Biology Series describes key techniques for experimentally detecting SV40 in human tumors, for exploiting its use in human gene therapy, and for studying its replication and its mechanisms of neoplastic transformation. Included are methods for growing SV40 and related viruses in tissue culture, for in vivo and in vitro replication and transcription of SV40 DNA, for use of retroviral vectors to express SV40 tumor antigens in cultured cells, and for use of transgenic mouse models based on the SV40 large T antigen.
	Z701688	Sample Preparation Techniques in Analytical Chemistry	The importance of accurate sample preparation techniques cannot be overstated. It is the midway point where the analytes from the sample matrix are transformed so they are suitable for analysis. Even the best analytical techniques cannot rectify problems generated by sloppy sample pretreatment. This book addresses diverse aspects of these necessary pretreatment steps. These include: State-of-the-art extraction techniques for organic and inorganic analytes; Sample preparation in biological measurements; Sample pretreatment in microscopy; Surface enhancement as a sample preparation tool in Raman and IR spectroscopy; Sample concentration and clean-up methods; Quality control steps.
	Z703168	Sample Preparation for Hyphenated Analytical Techniques	Hyphenation - linking together of "standard" analytical techniques - generally leads to enhanced analytical performance. Hyphenated techniques are widely used in analytical chemistry, and particularly in areas where samples are presented in complex matrices, e.g. environmental, pharmaceutical and biochemical or biomedical analysis. Sample preparation is often the most time consuming step in these analyses, exerting a huge influence on the speed, accuracy and precision of the analytical results. This book demonstrates the sample preparation chemistry that has enabled the present sensitivity, specificity and high throughput available and illustrates the successful utilization of existing sample preparation methodologies in various analytical applications.
	Z703192	Sax’s Dangerous Properties of Industrial Materials, 11th ed. 3 volume set	Since the 1950's, this book has been the number one resource for those who need to evaluate the hazard of substances used in commerce. The eleventh edition contains extensive data on approximately 26,000 substances, including 2000 new entries. The three-volume set includes Immediately Dangerous Life or Health (IDHL) levels for approximately 1000 chemicals, proving essential for designing adequate ventilation systems and selection of respiratory protection. Other highlights include: A special appendix containing information of nerve gases and biological agents that might appear in the workplace as a result of terrorist activity; the only reference that combines, for so many substances, data on toxicological, fire, reactivity, explosive potential, and regulatory information; Regulatory data covers exposure level classifications for a number of regulatory agencies, from OSHA to the U.S. Department of Transportation.
	Z700649	Scientists Must Speak: Bringing Presentations to Life	Having the ability to present confidently, engage the audience, make a clear, well-argued case, and handle any tricky situations, is rarely a natural talent, but it can be learned. This book can help. The majority of scientists have had occasion to stand up in front of an audience or grant funding panel. For scientists, this is complicated by the specialist nature of the data. The book includes sections on targeting your talk, taking control, handling question and answer sessions, expecting the unexpected, and adapting material for different situations.
	Z121487	Selections From The Aldrichimica Acta, 1968-1982	Contains 49 articles published in Aldrichimica Acta from 1968 to 1982.
	Z705233	Separation Methods in Proteomics	Protein separation techniques have been refined to minimize variability, optimize particular applications, and adapt to user preferences in the analysis of proteins. This book provides an examination of all major separation techniques for proteomics research. A compilation of hands-on methods, it may serve as a guide for selection of the optimal separation strategies to solve particular biological problems. Progress in the development of robust analytical techniques and instrumentation has created the need for good quality biological samples that are subject to analysis. Emphasizing the importance of sample preparation, the book explains how proteomes can be divided into smaller, less complicated "subproteomes" for individual analysis.
	Z375551	Sequence Data Analysis Guidebook: Methods in Molecular Biology, Vol. 70	Leading researchers demonstrate how to examine the data produced by modern automated sequencing, how to assess quality, how to delete extraneous data and how to align sequence fragments using the most popular sequence analysis software packages available. Procedures for comparing newly derived sequences with the massive libraries of sequence databases are fully covered along with techniques for performing restriction analysis on, and making detailed analyses of, the expressed proteins. •Includes complete tutorials for the leading sequence analysis software packages. •Shows how to create detailed graphic representations of restriction sites. •Demonstrates how to produce complex, publication-quality figures. •Offers many protocols by the original developers, with input from experienced users.
	Z701726	Short Protocols in Cell Biology	Providing condensed descriptions of more than 500 methods compiled from "Current Protocols in Cell Biology", this text explores cell biology in an easily accessible, hands-on format. This is an authoritative and indispensable guide for all life scientists and researchers. The text is designed to provide quick access to step-by-step instructions for the essential methods used in every major area of cell biological research, and it contains methods from every aspect of cell biology everything needed to study the basic structure and functions of cells at both the molecular and cellular levels
	Z703273	Short Protocols in Human Genetics	Short Protocols in Human Genetics is a compendium of methods from Current Protocols in Human Genetics, part of the well-known series that set the standard of excellence for laboratory manuals. Short Protocols in Human Genetics provides coverage of the latest methods in human genetics, including collecting family histories and pedigrees, linkage analysis, molecular genetics, physical mapping, clinical testing, and cytogenetics
	Z703664	Short Protocols in Immunology	This is an easy-to use companion to Current Protocols in Immunology. Drawn from the most fundamental and widely used methods in the well-known parent volume, this book provides step-by-step protocols in their most easily accessible format for use at the bench. Immunologists in basic science and clinical work alike will find techniques they rely on, including production, purification, and fragmentation of antibodies; assays for lymphocyte function; measurement of cytokines and cytokine receptors; biochemistry of lymphocyte activation; innate immunity, isolation of human immune cell populations, detection and analysis of HIV, and animal models for a variety of autoimmune and infectious diseases.
	S8441	Short Protocols in Molecular Biology, 5th ed., 2 Volume set	The new edition expanded to 2 volumes provides condensed descriptions of more than 700 methods compiled from Current Protocols in Molecular Biology. The books are specifically designed to provide quick access to step-by-step instructions for the essential methods used in every major area of molecular biological research. Includes new chapters on chromatin assembly and analysis, nucleic acid arrays, generation and use of combinatorial libraries, discovery and analysis of differentially expressed genes in single cells and cell populations.
	Z705985	Short Protocols in Neuroscience: Cellular and Molecular Methods	This volume is an easy-to-use compendium of cellular and molecular methods from Current Protocols in Neuroscience, part of the acclaimed series that has set the standard of excellence for laboratory manuals. It provides a portable and streamlined at-the-bench resource, covering methods for analysis of neural cell strucutre and function, isolation and culture of neural cells and characterization of neural cell gene expression.
	Z705993	Short Protocols in Neuroscience: Systems and Behavioral Methods	Short Protocols in Neuroscience: Systems and Behavioral Methods provides a portable and streamlined at-the-bench resource of systems and behavorial methods from the acclaimed Current Protocols in Neuroscience. It covers areas such as electrophysiological analysis of neural cells, the chemistry and pharmacology of the nervous system, behavioral analysis, and animal models of neurologic and psychiatric disorders.
	Z730459	Short Protocols in Pharmacology and Drug Discovery	Short Protocols in Pharmacology and Drug Discovery provides condensed descriptions of more than 350 methods compiled from the successful title Current Protocols in Pharmacology. The book is specifically designed to provide quick access to step-by-step instructions for the essential methods used in every major area of pharmaceutical research, and especially stresses drug discovery techniques.
	Z701653	Short Protocols in Protein Science	"Short Protocols in Protein Science" provides condensed descriptions of more than 500 protocols compiled from "Current Protocols in Protein Science". Drawing from both the original "core" manual as well as the quarterly update service, this compendium includes all step-by-step descriptions of the principal methods covered in "Current Protocols in Protein Science".
	S2639	Sigma Library of FT-IR Spectra, Volumes 1 and 2	This set contains over 10,400 FT-IR spectra of biochemicals and related organics. Spectra are linear in wavenumber with 2 cm ^-1 resolution, measure 18 × 4.5 cm and are arranged by categories.
	Z160008	Sigma-Aldrich^® Library of Chemical Safety Data, 2-volume set	Convenient reference for the safe handling of over 14,500 chemicals representing 24,000 Sigma and Aldrich products. Two volume set.
	Z231045	Sigma-Aldrich^® Library of Regulatory & Safety Data, 3-volume set	A compilation of international safety and regulatory information used for hazard evaluation, labeling, transportation, regulatory reporting, storage, and handling for more than 20,000 pure chemicals. Arranged by chemical class and structure for analogical data assignment. Indexed alphabetically by chemical name, CAS number, molecular formula, and Aldrich, Fluka, and Sigma catalog numbers. Three volume set.
	Z175005	Sigma-Aldrich^® MSDS Subscription single-user, US version/English language, One year subscription	Sigma-Aldrich Material Safety Data Sheets Contains more than 90,000 Sigma, Aldrich, Fluka, Supelco, and Riedel-de Haën chemicals on DVD. Features: • Emergency overview • HMIS and NFPA ratings • Transportation data from DOT, IATA, and ADR/AID • Canadian DSL & NDSL lists Country specific content: • European country specific OELs • Swiss poison classes • Annex listings updated • And more... MSDS DVD's are customized with country-specific regulatory requirements, data and language. Subscribers receive quarterly updates on a new DVD that includes new products and updated safety information. Search fields include: catalog number, CAS registry number; and more than 600,000 chemical names and synonyms. Compatible with Windows 2000, XP, and VISTA. Subscribers receive quarterly updates. Network versions are licensed on a concurrent user and server basis and require a signed license agreement. For information on network versions please contact your local sales office. Custom version includes data and indices appropriate for each file format.
	Z705403	Sigma-RBI Handbook of Receptor Classification and Signal Transduction, 5th ed.	The expanded 5th edition presents concise information on the characterization and classification of a wide range of receptors, ion channels, transporters, neurotransmitter synthesis/metabolism pathways and intracellular signaling enzymes. In addition to updating and revising over 80 previous handbook entries, 26 new entries have been added with a strong focus on kinases and ion channels. Each peer-reviewed entry consists of an easy-to-read and up-to-date overview of the available information in the area, as well as a list of 12 key references to guide both the new investigator and the experienced researcher in their searches and reviews of the current literature. Each entry includes a table that presents the currently accepted classification of a given receptor, ion channel, enzyme or transporter into its component subtypes and subgroups. It also highlights the pharmacological tools with which to investigate their function and regulation.
	S5316	SigmaPlot^® version 11	SigmaPlot Makes Analyzing and Presenting Your Data Easier Than Ever! New Features in SigmaPlot : • Instantly access SigmaPlot from Microsoft Excel - Launch SigmaPlot's Graph Wizard directly from Microsoft Excel without transferring files or cutting and pasting data • Get more editing flexibility with new toolbar palettes - SigmaPlot delivers more editing flexibility with new toolbar palettes • Edit text directly on your graphs - Now editing text on your graphs is as easy as using a word processing program! • Gain more control over legends with new improvements - Now you can choose to lock or unlock your legends when making changes to your worksheet. • Easily insert Microsoft objects on your graphs - Place regression equations, clip art, Microsoft Excel tables and Microsoft Word text or MS Equation Editor objects right onto your SigmaPlot graphs and reports. • Multiple Undo, Autosave, Nudge and more
	Z361747	SigmaScan^® Pro	SigmaScan Pro's comprehensive list of image types ensures image compatibility- including up to 16-bit grayscale images. You can convert images to different types, paste or splice images from one type to another, or modify pixel resolution while maintaining the aspect ration of the image. The powerful Histogram Stretch option lets you sharpen the contrast of color or grayscale images. Other enhancement techniques allow you to correct background lighting effects, apply color templates to grayscale images for highlighting hidden features or employ mathematical filters to add, remove, erode or dilate objects on an image. Plus, SigmaScan Pro's Image Math functions let you remove noise and highlight features by adding, subtracting or averaging the pixel intensities of different images.
	Z365785	SigmaStat^®	Includes new features like exploratory graphs, a graph editor and an enhanced report editor. Powerful statistical analysis made easy. Analyze your data by almost any standard statistical method you choose. Print detailed reports of results or enhance your reports with graphs produced by SigmaPlot. SigmaStat ensures that you: • Use the proper statistical method to analyze your data • Avoid the risk of statistical error • Interpret the results correctly • Generate an appropriate display and a professional report · Be sure you've analyzed your data correctly. And save time, too! SigmaStat is used by thousands of research scientists worldwide to: • Compare effects among groups, including before-and-after or repeated measures studies • Conduct survival and reliability analyses • Analyze rates and proportions • Perform regression and correlation analyses • Calculate power and sample size
	S2066	Signal Transduction	This text explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and coordinated. The first half explains the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. Later it deals with the formation of complex signaling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, to regulate gene transcription. It ends with a description at the molecular level of how signaling proteins interact with their environment and with each other through their structural domains.
	Z702897	Signal Transduction Protocols 2nd ed.	Carrying on the high standards of the acclaimed first edition, highly experienced investigators have extensively updated the first edition with many of the new approaches that have been transforming the field. Included in this edition are readily reproducible immunoassays, fluorescence-based assays, high-throughput methods, protein modification assays, lipid second messenger assays, and chromatin immunoprecipitation techniques. Wherever possible, protocols for the assay of general classes of signal transduction components have been identified so they can be adapted to the assay of any member of that class.
	Z701084	Signal Transduction and Human Disease	This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable
	Z702757	Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles	Reactive oxygen and nitrogen species (ROS/RNS) have taken center stage in the field of signal transduction. The enzymes responsible for the production of ROS and RNS have been unraveled and the participation of these species in numerous signaling pathways has been documented. The next step is to identify the targets of ROS and RNS and the mechanisms by which they alter their activity in the affected signaling pathway. . This book provides relevant chemistry that can be applied across signaling systems and summarizes the current state of knowledge in the area of redox signaling. ROS and RNS have been implicated in inflammation, aging and cancer.
	S8563	Signaling Networks and Cell Cycle Control	Leading scientists summarize latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on components of novel signaling networks controlling activity of nuclear transcription factors and cell cycle regulatory molecules. This is a guide for all investigators of cell regulation and its emerging pharmacological opportunities.
	S9932	Signaling Through Cell Adhesion Molecules	The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing, and malignant transformation. However, it is only recently realized that cell adhesion molecules are capable of transducing biochemical signals across the plasma membrane to regulate cellular functions. Many chapters not only contain the ‘recipes‘ on experimental protocols, but also discuss the rationale behind their development.
	Z552313	Silicon Chemistry: From Atom to Extended Systems	The combined results from an international research project involving 40 interdisciplinary groups, providing the latest knowledge from the past few years. Adopting an application-oriented approach, this handy reference is a must-have for every silicon chemist, whether working inorganic, organic, physical or polymer chemistry, materials science or physics.
	Z422428	Silicon in Organic, Organometallic, and Polymer Chemistry	This work sets itself apart from other books on silicon chemistry with its remarkably clear, well-organized, practical overview of the field. Geared to synthetic chemists and non-specialists alike, it covers all aspects of organosilicon chemistry, including fundamentals of silicon reactivity, formation and cleavage of non-carbon bonds to silicon, and formation and cleavage of silicon-carbon bonds.
	Z730548	SimGlycan software	Accurate Glycan Structure Prediction SimGlycan predicts the structure of a glycan from the MS/MS data acquired by mass spectrometry, facilitating the study of glycosylation and post translational modification studies. SimGlycan accepts the experimental MS profiles generated by a mass spectrometer, matches them with its own database of theoretical fragmentation of over 7,000 glycans and generates a list of probable glycan structures. Each structure is scored to reflect how closely it matches your experimental data. Other biological information for the probable glycan structures such as the glycan class, reaction, pathway and enzyme are also made available for easy reference. Glycan Mass Spectrometry Identification Tool SimGlycan is an innovative glycan mass fingerprinting tool. SimGlycan predicts the glycan structure, scores it and generates a list of probable glycans that closely match the your experimental MS profile saving you the time and the frustration of laborious work. Glycan Mass Fingerprinting for Studying Glycosylation and Post Translational Modifications Glycosylation is the result of addition of a glycan to a protein and represents the most common of all the known protein post-translational modifications. Carbohydrates have been found to participate in many biological processes including embryonic development, inter and intracellular activities, coordination of immune functions, pathogens homing on their host tissues, cell division processes and protein regulations and interactions. For facilitating such studies, SimGlycan predicts the structure of a glycan from the MS/MS data acquired by mass spectrometry. SimGlycan accepts the experimental MS profiles generated by a mass spectrometer, matches them with its own theoretical fragmentation database and generates a list of probable glycan structures. Each structure is scored based on how closely it matches your experimental data. Additional known biological information for the structures such as glycan class, reaction, pathway and enzyme is displayed, saving you from having to retrieve it from many sources. Robust Glycan Database The SimGlycan database is a large relational database populated with theoretical fragments of known glycan structures made up of 42 different monosaccharides. Every glycan in the database is fragmented for each of the possible thirty four reaction conditions using an intensive fragmentation algorithm. This ensures that the probable glycan fragments reported are comprehensive and accurate. Every effort has been made while populating this database to make it extremely high quality, enabling reliable data mining for future applications of glycobiology. SimGlycan database supports 8178 glycans, 7526 biological sources, 3498 glycan compositions, 5406 classes, 196 biochemical reactions, 148 biochemical pathways, 177 enzymes and 7234 database links. References Domon and Costello, (1988),"A Systematic Nomenclature for carbohydrate fragmentations in FAB-MS/MS Spectra of Glycoconjugates”, Glycoconjugate 5:397-409. David J. Harvey,"Collision-induced fragmentation of negative ions from N-linked glycans derivatized with 2-aminobenzoic acid ", Journal of Mass Spectrometry, 5: 42-653. Wuhrer M and Deelder AM,(2006),"Matrix-assisted laser desorption/ionization in-source decay combined with tandem time-of-flight mass spectrometry of permethylated oligosaccharides: targeted characterization of specific parts of the glycan structure", Rapid Commun. Mass Spectrom. 20: 1–9. Morelle W, SlomiannyMC, Diemer H, Schaeffer C, Dorsselaer AV and Michalski JC, (2004)," Fragmentation characteristics of permethylated oligosaccharides using a matrix-assisted laser desorption/ionization two-stage time-of-flight (TOF/TOF) tandem mass spectrometer", Rapid Commun. Mass Spectrom. 18: 2637–2649.
	S9813	SimVector	An exceptional software to design cloning experiments and drawing publication quality plasmid vector maps • Web integration - Automatically connects to Entrez for sequence retrieval • Graphical Entrez features - Transforms GenBank annotations to graphical features • Web ready images - Outputs images in JPEG format for addition to web sites • Publication quality images - Outputs images in high resolution TIFF format for publication • Plan cloning experiments - Designs PCR TA cloning, restriction enzyme, and Cre recombinase cloning experiments • Sequence editing - Easily place inserts in vectors by cutting and pasting • Active analysis - Automatically updates enzymes and features as a DNA sequence is edited • Easy styling - Hundreds of fonts, colors, styles and fill patterns for enzymes and features • Marquee select - Group select objects to quickly set styles for all • Automatic overlap avoidance - Built in algorithm keeps enzymes and feature labels from overlapping • Linear and circular views - Produces both circular and linear graphical maps • Zooming - Zoom in for detailed graphics or out for an overview • Folders - Keep all sequence files organized by lab, researcher, or project • Sequence import - Move sequence files from computer to computer or e-mail over the Internet. • Comprehensive database - Analyzes for restriction sites with database of more than 900 enzymes • Enzyme Filtering - Select restriction enzymes by overhang, recognition site length, etc. ·
	Z700339	Single Nucleotide Polymorphisms: Methods and Protocols	This is a comprehensive collection of readily reproducible techniques for the difficult process of single nucleotide polymorphisms (SNP) discovery and genotyping. These cutting-edge protocols for mutation/SNP detection utilize denaturing high-performance liquid chromatography (dHPLC), single-strand conformation polymorphism (SSCP), conformation-sensitive gel electrophoresis (CSGE), chemical cleavage, and direct sequencing. Equally powerful and up-to-date methods are given for genotyping SNPs, including molecular beacons, the Taqman assay, single-base extension approaches, pyrosequencing, ligation, the Invader assay, and primer extension with mass spectrometry detection.
	S7440	SlideWrite^™ plus Version 6, CD-ROM	Technical graphing, curve-fitting and data analysis functions that can transform your data into technical graphs and charts that are impressive and memorable. A technical presentation program for development of publication-quality graphs, charts, and scientific figures. Along with full statistics, curve-fitting, and data analysis features, SlideWrite also boasts drawing capabilities, optional libraries of scientific clip art, and a wide range of device drivers for slidemakers, printers, plotters, and cameras. Exports TIFF, PCX, CGM, EPS, and HPGL files; imports Lotus, ASCII, and PCX files, among others.
	Z513776	Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries	This book addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.