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Immunomodulators

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Description	Biochem/physiol Actions	Product #
Cyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid	A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.	C3662
Cyclosporin A from Tolypocladium inflatum, for molecular biology, ≥95%	A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria. Potent immunosuppressive agent, inhibiting primarily T lymphocytes.	C1832
Hymenistatin I >99% (HPLC)	Exerts an immunosuppressive effect on humoral and cellular immune responses similar to cyclosporin A.	H8409
[Met²¹⁰]-Melanocyte Protein PMEL 17 Fragment 209-217 human, mouse >98% (HPLC), solid	Modification of the melanoma differentiation antigen gp100/PMEL 17 fragment 209-217 sequence with greater affinity for the HLA-A2 molecule than the unmodified peptide. Has an increased ability to generate melanoma-reactive cytotoxic T lymphocytes in vitro.	M0563
Thymosin α₁ bovine ≥90% (HPLC)	Hormone produced by thymic stromal cells that can augment host defense mechanisms, by increasing the production of T cells by thymus and restoring T cell-mediated antibody production in immunodeficient animals..	T3410
Val-Glu-Pro-Ile-Pro-Tyr ≥97% (HPLC)	An immunostimulating peptide from human caseins	V2256
Z-Ala-Ser-Thr-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid	Cell permeable inhibitor of endothelial monocyte-activating polypeptide II (EMAP-II).	C9359

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