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Potassium Channel Modulators

Description
Biochem/physiol Actions
Product #
Apamin from bee venom, ≥95% (HPLC) The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
 A1289
Apamin synthetic, ≥97% (HPLC) The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
 A9459
Charybdotoxin ≥90% (HPLC) High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
Potent and selective inhibitor of the Ca2+-activated K+ channel present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.
 C7802
Charybdotoxin >98%, recombinant, expressed in Escherichia coli, lyophilized powder High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
 C5856
[Gln12]-Charybdotoxin ≥85% C8089
[His19]-Charybdotoxin ≥85% C7839
[Lys(Ac)11]-Charybdotoxin ≥85% C8214
Iberiotoxin Selective and reversible inhibitor of high-conductance calcium-activated potassium channel.
 I2141
Margatoxin ≥90% (HPLC) Specific K(V)1.3 channel voltage-dependent K+ channel blocker
 M8278
Mast Cell Degranulating Peptide Toxic component of bee venom that selectively blocks some neuronal voltage-gated K+ channels; degranulates mast cells and releases histamine
 M8036
Mast cell degranulating peptide HR1 ≥97% (HPLC) Peptide from giant hornet Vespa orientalis that has biological effects similar to mast cell degranulating peptide from bee venom
 M8655
Tertiapin >95% A potent inhibitor of the inward-rectifier K+ channels, blocked a G-protein-gated channel (GIRK1/4) and the ROMK1 channel with nanomolar affinities, however a closely related channel, IRK1, was insensitive to tertiapin. Thus, tertiapin is a tool for purifying functional channels as well as for screening pharmaceutical agents against these channels.
 T8316
Tertiapin-Q trifluoroacetate salt ≥97% (HPLC) Blocks the GIRK1/4 and ROMK1 members of the inward-rectifier K+ channel family.
 T1567

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