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Amyloid beta Protein Fragments

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Description	Biochem/physiol Actions	Product #
Acetyl-Amyloid β-Protein Fragment 15-20 Amide ≥97% (HPLC), powder	Hexapeptide that binds Aβ and prevents fibril formation.	A6933
[Asn(4-aminobutyl)^1,7,23,Gln(4-aminobutyl)^3,11,22]-Amyloid β-Protein 1-40 ≥90% (HPLC)	Modified amyloid beta-peptide that may be used to detect plaques in vitro or in vivo allowing for the early diagnosis of Alzheimer's disease.	A1097
[Gln¹¹]-Amyloid β-Protein fragment 1-16 ≥97% (HPLC)		A4309
Amyloid β Protein Fragment 1-38 ≥97% (HPLC), powder	β-Amyloid peptide that forms cross-β-sheet fibrils of 70-90 Å diameter with similar antigenicity as those found in Alzheimer's disease.	A0189
Amyloid β Protein Fragment 1-40 ≥90% (HPLC), powder	Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer's disease.	A1075
Amyloid β-Protein Fragment 40-1 ≥90% (HPLC)	Inactive control against Αβ [1-40].	A2326
Amyloid β Protein Fragment 1-42	The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer's disease and Down's syndrome.	A9810
Amyloid β-Protein Fragment 1-43	Primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome	A7712
[pGlu³]-Amyloid β-Protein Fragment 3-42 ≥90% (HPLC), solid	Predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. It is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits.	A2597
Amyloid β-Protein Fragment 10-20 ≥97% (HPLC), lyophilized powder	Amyloid β protein fragment containing the α-secretase processing site (Lys¹⁶-Leu¹⁷ bond). It also contains the HHQK domain (residues 13-16) responsible for binding to microglial cells. This fragment is also a substrate for matrix metalloproteinase-2 (MMP-2 or gelatinase A).	A6825
Amyloid β-Protein Fragment 12-28 ≥97% (HPLC)	Impairs post-training memory in mice upon injection into limbic system structures.	A3180
[Pro¹⁸, Asp²¹]-Amyloid β Protein Fragment 17-21 trifluoroacetate salt ≥98% (HPLC), solid	Inhibits amyloid formation in vitro, prevents amyloid neurotoxicity in cell culture, reduces in vivo cerebral amyloid deposition and completely blocks amyloid fibrial formation in rat brain.	A3097
Amyloid β-Protein Fragment 17-28 ≥90% (HPLC), lyophilized powder		A4723
Amyloid β-Protein Fragment 17-40 ≥87% (HPLC), lyophilized powder		A4848
Amyloid β-Protein Fragment 22-35 ≥95% (HPLC)	Has cytotoxic effect on cultured neurons from rat hippocampus in serum free medium. Also forms aggregates and fibrils similar to those of β-amyloid protein in senile plaque cores.	A5080
Amyloid β-Protein Fragment 25-35 ≥97% (HPLC)	Functional domain of Aβ required for both neurotrophic and neurotoxic effects.	A4559
Amyloid β-Protein Fragment 32-35 ≥95% (HPLC)		A4950
Amyloid β-Protein Fragment 35-25 ≥95% (HPLC)	Inactive control	A2201
Amyloid-β-Protein Fragment 1-40, All D-Amino Acids >70% (HPLC), lyophilized powder		A5973
Amyloid β-Protein Fragment 1-40 amide trifluoroacetate salt ≥95% (HPLC), lyophilized powder		A4473
[Arg¹³] Amyloid-β-Protein Fragment 1-40 ≥95% (HPLC), lyophilized powder		A7973
[Nle³⁵]-Amyloid β-Protein Fragment 1-40 ≥90% (HPLC), lyophilized powder		A4348
[Phe¹⁰]-Amyloid β-Protein Fragment 1-40 ≥95% (HPLC), lyophilized powder		A4223

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