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OB Ligands

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Description	Biochem/physiol Actions	Product #
Leptin from mouse ≥97% (SDS-PAGE), recombinant, expressed in Escherichia coli, lyophilized powder	Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo. Human and mouse leptin share ~84% sequence identity.	L3772
Leptin from rat ≥97% (SDS-PAGE), recombinant, expressed in Escherichia coli, lyophilized powder	Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo. Human and mouse leptin share ~84% sequence identity.	L5037
Leptin human >97% (SDS-PAGE), recombinant, expressed in Escherichia coli, lyophilized powder	Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo. Human and mouse leptin share ~84% sequence identity.	L4146
Leptin Fragment 116-130 Amide mouse >95% (HPLC), white powder	Mimics the effects of recombinant leptin on body weight and food intake.	L6788
Leptin Fragment 138-167 human >91% (HPLC), white powder		L7038
Leptin Fragment 150-167 human 89% (HPLC), white powder		L7163
Leptin Receptor/Fc Chimera from mouse ≥97% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder, cell culture tested	Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.	L4912
Leptin Receptor/Fc Chimera human ≥97% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder, cell culture tested	Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.	L4787

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