Fas and Related Proteins with Death Domains The death domain (DD) of Fas (FADD) shows high-sequence homology to the Drosophila melanogaster protein reaper. The death domain is also found in tumor necrosis factor receptor 1 (TNF-R1), TNF-R1-associated death domain (TRADD), Fas-associated death domain (FADD), and Fas receptor-interaction protein (RIP). Fas and FADD associate through their homologous DD while TNF-R1 and TRADD associate through their homologous DD.
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