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GABA and Glycine Receptor Modulators

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Description	Biochem/physiol Actions	Product #
21-Acetoxypregnenolone		A3750
ALX-1393 >98% (HPLC), powder	GlyT-2 glycine transporter inhibitor.	A5475
ALX 5407 hydrochloride >98% (HPLC), solid	Selective, irreversible GlyT-1 glycine transporter inhibitor.	A8977
(E)-4-Amino-2-butenoic acid solid	Potent GABA_c receptor agonist.	T1694
γ-Aminobutyric acid ≥99%	Major inhibitory neurotransmitter in brain; GABA_A and GABA_Breceptor agonist; increases Cl⁻ conductance.	A2129
cis-4-Aminocrotonic acid solid	GABA_C receptor agonist	A201
3-Amino-1-propanesulfonic acid sodium salt ~98%	GABA_A receptor agonist.	A4147
tert-Butyl bicyclo[2.2.2]phosphorothionate solid	GABA_A receptor antagonist; chloride channel blocker; extremely potent convulsant.	B104
Carbamazepine powder	Anticonvulsant; ligand for the GABA_A receptor benzodiazepine modulatory site. Sodium channel inhibitor	C4024
Carbamazepine meets USP testing specifications	Anticonvulsant; ligand for the GABA_A receptor benzodiazepine modulatory site. Sodium channel inhibitor	C8981
Chlormethiazole hydrochloride ≥98% (HPLC), crystalline	GABA_A agonist; glycine receptor modulator.	C1240
Cloflubicyne ≥95% (NMR), solid		C1983
DEABL ≥98% (LC/MS), solid	Positive modulator of GABA_A receptor; anticonvulsant	D1193
Dehydroisoandrosterone 3-sulfate sodium salt dihydrate ≥98%, powder	Dehydroisoandrosterone 3-sulfate sodium salt dihydrate is a negative allosteric modulator of GABA_A receptors.	D5297
16-Dehydropregnenolone acetate ≥95%		D4875
3α,21-Dihydroxy-5α-pregnan-20-one ≥95%	Positive allosteric modulator of GABA_A receptors.	P2016
3α,12α-Dihydroxy-5β-pregnan-20-one 3,12-diacetate		P5902
16,17-Epoxy-21-acetoxypregnenolone ≥98%		E4625
16α,17α-Epoxypregnenolone		E4875
16α,17α-Epoxypregnenolone acetate ~95%		E5000
Etbicyphat ≥95% (NMR), solid	Blocker of neuronal voltage-dependent and GABA-gated chloride channels; non-competitive GABA antagonist; causes epileptiform seizures.	E5277
Etbicythionat ≥98% (NMR), solid	A potent non-competitive GABA antagonist in mammals; causes epileptiform seizures.	E5402
Etomidate >98% (HPLC), powder	Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage	E6530
Flucybene ≥95% (NMR), solid	A potent non-competitive GABA antagonist in mammals, molluscs and insects; convulsant.	F6551
Gabapentin solid	Anticonvulsant with unknown mechanism of action; crosses the blood brain barrier; increases GABA concentrations in the brain and reduces excitatory amino acid neurotransmission, perhaps through its effects on voltage-gated calcium channels; exhibits antinociceptive, anxiolytic, neuroprotective and anti-epileptic effects.	G154
Gaboxadol hydrochloride solid, ≥98% (HPLC)	GABA_A receptor agonist.	T101
Ganaxolone solid	Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.	G7795
Glycine ReagentPlus^®, ≥99% (TLC)	Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.	G7126
Glycine hydrochloride ≥99% (TLC)	Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.	G2879
Glycine sodium salt ≥99% (TLC)	Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.	G6761
GS39783 ≥98% (HPLC), powder	Positive allosteric modulator of GABA_B receptors	G5919
Guvacine hydrochloride ≥97% (NMR), solid	GABA uptake inhibitor.	G007
(1S,9R)-(+)-β-Hydrastine	Potent competitive GABA_A receptor antagonist which is more potent than bicuculline; isolated from Corydalis stricta.	H8645
γ-Hydroxybutyric acid sodium salt	Endogenous GABA analog that induces absence-like seizures. It blocks dopamine release by blocking impulse flow in dopaminergic neurons.	H3635
17α-Hydroxypregnenolone		H5002
17α-Hydroxypregnenolone 3-acetate ≥98%		H5127
Hypotaurine ≥98% (TLC), powder	Antioxidant that binds hydroxyl radicals. Endogenous inhibitory neuromodulator that is blocked by strychnine and picrotoxin. Inhibits the Na²⁺-dependent transport of GABA and β-alanine. It is a degradation product of cysteine and a precursor of taurine.	H1384
Imidazole-4-acetic acid sodium salt	Competitive antagonist at GABA_C receptors.	I7013
Isoguvacine hydrochloride solid	GABA_A receptor agonist.	G002
16-Methylene-17α-hydroxypregnenolone 3-acetate		M8626
Muscimol powder	GABA_A receptor agonist.	M1523
Muscimol hydrobromide ≥98% (HPLC), solid	Muscimol hydrobromide is a GABA_A receptor agonist.	G019
Nipecotic acid 98%		211672
NO-711 hydrochloride solid, ≥98% (HPLC)	Potent and selective GABA uptake inhibitor that crosses the blood-brain barrier.	N142
Phenylbenzene ω-phosphono-α-amino acid solid	Selective strychnine-sensitive glycine receptor antagonist.	P204
Picrotoxin powder	GABA_A receptor antagonist; binds to the GABA receptor-linked Cl⁻ channel.	P1675
Picrotoxinin	GABA_A receptor antagonist; binds to the GABA receptor-linked Cl⁻ channel.	P8390
Piperidine-4-sulfonic acid	GABA_A receptor agonist.	P9159
5α-Pregnan-3α-ol-11,20-dione powder, ≥98% (TLC)	Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABA_A receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABA_A receptor; anesthetic. The alpha subunit subtype of GABA_A determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.	P5052
5α-Pregnan-3α-ol-20-one solid	Positive allosteric modulator of GABA_A chloride channel.	P8887
5α-Pregnan-3β-ol-20-one 3β-acetate ≥98%		P8004
Pregnenolone sulfate sodium salt	Neurosteroid that antagonizes the GABA_A receptor chloride channel.	P162
Propybicyphat 95% (NMR), solid	GABA-gated chloride channel blocker, non-competitive GABA antagonist in mammals.	P5489
Salicylidene salicylhydrazide ≥98% (HPLC), solid	Potent and selective inhibitor of α₂β₁γ₁δ GABA_A receptor subtype.	S8194
SB 205384 solid	GABA_A receptor modulator selective for theα<ΣΥΒ>3β<SUB>2></SUB>γ_{2</SUB>ΣΥΒS}subunit combination.	S7936
D-Serine ≥98% (TLC)	Glycine mimic active at the strychnine-insensitive glycine binding site associated with the NMDA receptor as well as the inhibitory post-synaptic glycine receptor.	S4250
L-Serine ReagentPlus^®, ≥99% (TLC)	Precursor of glycine by serine hydroxymethyltransferase.	S4500
SKF-89976A >98% (HPLC), solid	GABA transporter type 1 (GAT-1) inhibitor that crosses the blood brain barrier.	S9066
(S)-SNAP-5114 ≥98% (HPLC), solid	GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2.	S1069
SR-95531 ≥98% (HPLC), solid	SR-95531 ia a specific GABA_A receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.	S106
Strychnine	Convulsant; glycine receptor antagonist not associated with the NMDA receptor.	S0532
Strychnine hydrochloride	Convulsant; glycine receptor antagonist not associated with the NMDA receptor.	S8753
Taurine ≥99%	Non-selective endogenous agonist at glycine receptors. Conditionally essential sulfonated amino acid which modulates apoptosis in some cells; functions in many metabolic activities; a product of methionine and cysteine metabolism.	T0625
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate ≥97% (HPLC), solid	TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABA_C receptors but not to interact with GABA_A or GABA_B receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABA_C receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABA_A receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABA_B receptors assayed in rat hippocampal slices (EC₅₀ approx. 500 μM). TPMP_A may be used to investigate GABA_C receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.	T200
(−)-α-Thujone purum, ≥96.0% (GC)		89231
Tofisopam ≥98% (HPLC), solid	Ligand for the GABA_Areceptor benzodiazepine modulatory site.	T8200

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