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Image	Product #	Book Title	Description
	G1540	G Protein-Coupled Receptors	Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has utilized contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal microscopic methods and the search for endogenous ligands for orphan receptors.
	I4029	Ion Channels and Disease	A number of human and animal diseases have been found to result from mutations in the genes encoding ion channel proteins, and are referred to as channelopathies. This chronicles our understanding of the molecular basis of ion channel diseases. It includes the relevant aspects of molecular biology and biophysics and a description of methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.
	Z705519	Ion Channels: Methods and Protocols	It is now clear that ion channels play essential roles in cell biology and physiology and that their dysfunction is the root cause of many human diseases. In this book internationally recognized biomedical scientists describe recent technological braekthroughs and demonstrate their use in successful experimental designs. The diverse applications range from the study of allosteric regulation of ion channel activity using a classic mutagenesis approach, to the study of channel subunit stoichiometry using a novel biophysical approach based on fluorescence resonance energy transfer. Highlights include methods for heterogenous expression of ion channels in cells for determining channel structure-function, for studying channel regulation and physiological function and for genetic screening and investigating channelopathies.
	P5736	Principles Of Molecular Recognition	Conn and Means provide an integrated review of the key areas—membrane receptor-initiated cell signaling and nuclear-receptor initiated gene regulation. These authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases.
	Z705403	Sigma-RBI Handbook of Receptor Classification and Signal Transduction, 5th ed.	The expanded 5th edition presents concise information on the characterization and classification of a wide range of receptors, ion channels, transporters, neurotransmitter synthesis/metabolism pathways and intracellular signaling enzymes. In addition to updating and revising over 80 previous handbook entries, 26 new entries have been added with a strong focus on kinases and ion channels. Each peer-reviewed entry consists of an easy-to-read and up-to-date overview of the available information in the area, as well as a list of 12 key references to guide both the new investigator and the experienced researcher in their searches and reviews of the current literature. Each entry includes a table that presents the currently accepted classification of a given receptor, ion channel, enzyme or transporter into its component subtypes and subgroups. It also highlights the pharmacological tools with which to investigate their function and regulation.
	Z700886	Textbook of Drug Design and Discovery, 3rd ed.	This edition has been thoroughly revised and updated to provide a complete source of information on all facets of drug design. The book follows drug design from the initial structure-activity relationship to the final processes of clinical evaluation and registration. Chapters investigate the design of drugs for particular cellular targets such as ion channels and receptors whilst others examine specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques and combinatorial approaches are also included.
	Z705551	Voltage Gated Ion Channels as Drug Targets	Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development.

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