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Image	Product #	Book Title	Description
	Z705373	AlleleID	Aligns sequences to locate differences in DNA and to find conserved regions, to design microarray and qPCR assays for pathogen detection, bacterial identification, species identification and taxa discrimination. Related Gene Assays- Designs species specific, taxa discrimination, cross species probes and primers for pathogen identification, strain discrimination, genotyping and biodiversity studies using microarray and qPCR technologies. Species Specific Assay Design- Designs probes and primers for species identification aligning sequences using ClustalW. It analyzes species specific regions to design primers and probes to amplify only the species or strain of interest. For Microarray and TaqMan™ assays, we have incorporated an innovative feature we call "Minimal Set". When selected, AlleleID designs the fewest number of probes and primers that will uniquely identify each of the desired species/strain in the mix, help saving costs. Taxa Discrimination/Cross Species Assay Design- Designs a single (common) probe and primer pair to identify a taxa or a group of organisms from the mix. The program limits the search to conserved regions. When such designs are not feasible, the program attempts the design by designing degenerate probes. Cross Species Microarrays- Micorarray technology combines nucleic acid amplification strategies with massive screening resulting in high level of sensitivity, specificity and throughput. You can design species specific microarrays for rapid diagnostics and surveillance tests. Not only you can design probes and primers for TaqMan/molecular beacon qPCR assays but also for microarrays. One could use both the techniques, verify microarray results using qPCR, or perhaps, make microarays based on probes through qPCR. Selective cDNA amplification- Avoids gDNA by designing primers across exon junctions. The exons are identified by interpreting GenBank header annotations or by specifying them manually. qPCR Assays- Designs optimal SYBR™ Green primers, TaqMan probes, FRET probes or molecular beacons for real time qPCR assays. Designs single or multiplex TaqMan and beacon assays for allele discrimination or gene expression studies. Allele discrimination SYBR Green and FRET assays can be designed as well. cDNA Microarrays for gene expression and SNP genotyping- Design thousands of oligos for making microarrays, or thousands of PCR primer pairs for cDNA microarrays. You can efficiently retrieve, analyze and store data, and export the results for ordering synthesis.
	Z704938	Array Designer	Helps design thousands of efficient, highly specific oligos to make microarrays for SNP genotyping and expression studies with the click of a button. For investigating gene control elements in the post-sequencing era, the software designs tiling arrays for interrogating intragenic and intergenic regions and now the software also designs resequencing arrays for analysis of large genomic sequences and genetic variation within the clinical trial population. Oligo microarray software: • Designs highly specific oligo microarray for SNP genotyping and expression studies • Helps design probes for expression and SNP studies • Flexible and scaleable for large projects • A high-throughput, greatly automated approach for designing highly specific optimal oligonucleotide probes for microarray experiments cDNA microarray design: • Uses optimized design parameters for cDNA microarray design • The default parameters help make the design a success • Highly sophisticated algorithm Whole genome array- useful for studying the poorly understood aspects of transcriptome, natural antisense transcript because they can simultaneously monitor gene expression on both strands of genome Tiling array- used to investigate transcription factor binding sites TFBS, not only upstream of genes but also in intronic and intergenic regions. Resequencing arrays- designs resequencing arrays useful for analysis of large genomic sequences and genetic variation within the clinical trial population. Flexible input formats- Support sequences in GenBank, FASTA. Loads multiple sequences from a single GenBank or FASTA format file. Standard PCR Reaction Conditions- Optimize PCR primers on all sequences to amplify with uniform reaction conditions. Multiple probes- Designs the best probe per sequence or multiple probes per sequence for increased accuracy of detection. SNP detection- Designs SNP probes for both hybridization and primer extension detection. Flexible Hybridization Probe Locations- Probes can be designed to span each site, or can have 3 ft end anchored at each site, or can be optimized within a specified region around the site.
	Z704903	Beacon Designer	Beacon Designer helps design successful SYBR™ Green, TaqMan™, LNA spiked TaqMan, molecular beacon for both standard and NASBA assays and FRET assays by interpreting BLAST results for specificity and locating oligos avoiding template structures. SYBR Green Primer Design- Highly specific primers are designed by avoiding significant homologies found by automatically interpreting BLAST search results. Primer efficiency is enhanced by avoiding template secondary structures identified by connecting to the Mfold server. Dual Labeled Probe Design: Dual-labeled fluorescent TaqMan, molecular beacon or FRET probes can be designed with the help of Beacon Designer. For these assays, you can design new primers and probes or find probes compatible with previously designed SYBR Green assays and save on synthesis costs. TaqMan probes and Molecular Beacon Multiplex experiments- Multiplex assays are designed by avoiding homologies with all primers and probes in the pool. This prevents competition in multiplex real time PCR reactions and assures high signal strength. Allelic Discrimination- Design both wild and mutant probes for SNP genotyping assays. LNA Probe Design- In addition to standard TaqMan probes, Beacon Designer also designs the increasingly popular LNA or Locked Nucleic Acid substituted TaqMan probes to improve real-time PCR assay success. NASBA Assays- Beacon Designer designs molecular beacon probes for NASBA assays for single template, multiplex or alleleic discrimination. BLAST Search- Both primers and templates/amplicons can be BLAST searched against genomic databases available at NCBI or against local custom databases. This function helps verify the primer specificity. Avoid Template Structures- Automatically avoid secondary structures in the template identified by connecting to the Mfold server while designing primers. Generate Report- Generate an attractively formatted
	Z362166	Buffer maker Windows^® version	Designs buffers using the Henderson-Hasselbalch equation. Has a library of over 500 buffer recipes! Also will calculate % constituent, ionic strength, dilution values, standardization values, pH, pK, and pKa.
	E0401	Enzfitter Windows version	EnzFitter is a generic curve-fitting package which has custom features designed to make it especially suitable for analysis of enzyme kinetics experiments. For example, initial rate and parameter values can be obtained with their confidence limits for single and twin substrate rate data. Built-in models include Michaelis-Menten with or without substrate inhibition, competitive, uncompetitive and mixed inhibition, ternary complex or ordered bi-bi systems and ping-pong with and without inhibition by substrates. You can easily add other models in conventional algebraic syntax EnzFitter can be set up to run in batch mode (performing several analyses automatically, without user intervention) and it also supports OLE Automation. For more general assay use, you can calculate unknowns from fitted standard curves. You can create text Notes that are attached to any file, dataset or curve fit. There is also an automatic Logbook which records all changes made to a given file. The 32-bit version supports Regional settings for things like decimal points. There is comprehensive Help and a manual
	E3529	Enzyme Kinetics Module 1.10 for SigmaPlot	This is an add-on to SigmaPlot 2000 that provides the curve fitting and graphing capabilities you need to analyze and present your enzyme kinetics data quickly and easily. The module follows SigmaPlot's tradition of award-winning interface, ease-of-use, and intelligent wizards to guide you through your entire analysis. Just enter your data, select the type of study and the equation you would like to fit, and utilize the interactive graphs to display your results. Using SigmaPlot's powerful non-linear curve-fitter, the module fits the selected equations to your data, and also provides the interactive graphs you need to see to study the kinetics mechanism. What's more, you get a detailed report complete with all statistical parameters for each model you fit so you can easily compare the different models to identify the best one for your data.
	G2777	Gene Construction Kit Brochure	Allows graphic manipulation of DNA Sequences and sophisticated plasmid drawing options. It has an award winning interface design that allows graphic manipulation of DNA sequences in addition to providing sophisticated drawing capabilities. GCK was named the "Best Plasmid Mapping Software" by the Biotechnology Software. • Ideal for planning and tracking complex construction projects • Manipulate actual DNA sequences through a unique and innovative graphical interface • View construct either as a text sequence or graphically, linear or circular • Automatically monitor and adjust DNA fragment ends during cutting and pasting • Define thickness, pattern, shape, direction, and color for each DNA segment • Search, download and import GenBank and EMBL files with all GenBank feature table items translated automatically into GCK features. • Unique Chronography feature tracks the history of any given DNA segment and maintains alternative views • Cut and paste DNA fragments from one construct to another (including segment history) • View predicted electrophoresis patterns of restriction digests including partial digests • Show DNA with protein sequence and/or with restriction enzyme or other sites of interest • Create illustrations containing multiple constructs, gels, sequence listings, free text, legends and other graphics • Create silent mutations to add or remove a restriction site from a sequence without changing the coding information • Mark restriction sites using one or more completely editable and expandable enzyme lists • Find Open Reading Frames using any codon table you specify • Display the name of any region within the construct window • Frame segments of DNA in the sequence display. Frames can encompass the site markers, sequence, and/or regions of a construct. • Display and manipulate multiple constructs in the same illustration window
	G0667	Gene Construction Kit For Windows	Allows graphic manipulation of DNA Sequences and sophisticated plasmid drawing options. It has an award winning interface design that allows graphic manipulation of DNA sequences in addition to providing sophisticated drawing capabilities. GCK was named the "Best Plasmid Mapping Software" by the Biotechnology Software. • Ideal for planning and tracking complex construction projects • Manipulate actual DNA sequences through a unique and innovative graphical interface • View construct either as a text sequence or graphically, linear or circular • Automatically monitor and adjust DNA fragment ends during cutting and pasting • Define thickness, pattern, shape, direction, and color for each DNA segment • Search, download and import GenBank and EMBL files with all GenBank feature table items translated automatically into GCK features. • Unique Chronography feature tracks the history of any given DNA segment and maintains alternative views • Cut and paste DNA fragments from one construct to another (including segment history) • View predicted electrophoresis patterns of restriction digests including partial digests • Show DNA with protein sequence and/or with restriction enzyme or other sites of interest • Create illustrations containing multiple constructs, gels, sequence listings, free text, legends and other graphics • Create silent mutations to add or remove a restriction site from a sequence without changing the coding information • Mark restriction sites using one or more completely editable and expandable enzyme lists • Find Open Reading Frames using any codon table you specify • Display the name of any region within the construct window • Frame segments of DNA in the sequence display. Frames can encompass the site markers, sequence, and/or regions of a construct. • Display and manipulate multiple constructs in the same illustration window
	Z530069	MolSuite™ 2000	“Modeling, property calculation, analysis, and database maintenance suite” MolSuite 2000 gives you molecular modeling with great graphics, physical property calculations, statistical analysis, and database development and management all in one complete package. Model building is easy in ChemSite^® Pro which provides fast minimization and displaying of any molecule, even crystals, in a 3D environment. Structures are easily copied and pasted to other MolSuite 2000 programs. Paste your molecule into Molecular Modeling Pro™ and run semi-empirical quantum mechanics and calculate up to 70 properties. Molecular Analysis Pro™ will enable you to use statistical regression techniques used in the plotting of chemical data. Use MolSuite to develop and maintain a database or use MolSuite^® DB, which contains over 24,000 organic molecules with chemical properties. MolSuite 2000 is a desktop chemist’s affordable integrated suite. Includes: ChemSite Pro, Molecular Modeling Pro, Molecular Analysis Pro and MolSuite DB (see descriptions above).
	Z528323	Molecular Modeling Pro™	A full-featured research tool for estimating physical properties from structures and generating QSAR and QSPR databases. Draw 3-D structures with a mouse then display, clip, and rotate them as wire frames, ball and sticks, shaded spheres, and dot surfaces. In combination with Molecular Analysis Pro™, this program is a complete package for QSAR/QSPR research. Includes an engine for performing substructure and similarity searches on directories of molecules. Has a reaction editor that automates drawing of reactions, performs stoichiometry and has some database features. Inputs and outputs MDL Molfiles, MacroModel files and MOPAC files, inputs Brookhaven PDB files and supports copy and paste of graphics to other Windows^® programs. • Display up to 40 molecules and 4,000 atoms • Color by atom type, residue, charge or lipophilicity. Includes a minimizer (2 methods), conformational analysis of 1 or 2 rotating bonds and Huckel, CNDO, and INDO semi-empirical quantum mechanics • Calculates over 70 physical properties from structure including HLB, Hansen’s 3-D solubility parameters (2 methods), boiling point, vapor pressure, water solubility, connectivity and valence indices, surface tension, polar surface area (TPSA), QlogP, steric hindrance, enzymatic hydrolysis, Modified Adjacency Matrix, partial charges, dipole moment, molecular volume, surface area, Sterimol parameters, etc • Automatically constructs databases of physical properties, including substituent parameters (pi, sigma, etc.) of whole directories of molecules or from a single substructure in minutes
	Z704857	PG200 (Progenesis) software	Progenesis PG200 provides simple laboratory image analysis for single stain 2D gels using a routine, three step approach – Set-up, Process and Review. With this approach an analysis is set-up in minutes, processed automatically and reviewed using a comprehensive suite of display options to show spots of interest. Analysis workflows can be tailored to the specific requirements of your lab using an intuitive user interface and step by step approach. Key features of PG200 include • Analysis Wizard to set-up entire an experiment for analysis • Automated Matching with option for manual seed placement • Background subtraction that is flexible and fully informative • Normalisation methods to perform accurate intensity calibration and MW/pl determination on your 2D gels • Editing tools to optimize analysis results • SameSpots spot outline method, which offers a brand new approach for analysing aligned images • Image views and measurements tables that highlight areas of interest and present results • Workspaces that can be recalled to display custom window layouts for easy data review
	Z704563	Phoretix 2D	2D electrophoresis is a key technique within life science research to separate and analyse protein mixtures. The use of 2D electrophoresis has evolved dramatically both in terms of the number of scientists utilising the technique and how it is applied within their research. As a result new technology is continually being developed and implemented by Nonlinear to meet the growing needs of researchers. This is an entry level product for quick, simple interpretation of 2D gel image analysis • Analysis wizard for simple setup of gel processing • Unique algorithms to help eliminate major noise features from affecting spot detection and matching • Spot detection that captures all spot material, with automatic splitting of overlapping spots • Automatic warping to drive accurate spot matching • Spot filters, manual warping and a suite of simple to use tools for edting analysis results • Automatic generation of t-test and ANOVA results • Sort and filter measurement to only display spots with interesting profiles • 2D and 3D image
	P7359	Primer Premier^™	A comprehensive primer design tool • PCR primer design- design primer pairs for PCR and multiplex experiments. • Cross species- Amplify sequences from multiple species. • Pathogenic detection- Locate oligos in highly conserved regions. • Allele specific- Exclusively amplify a single member of a set of related sequences. • Degenerate- Start with an amino acid sequence, reverse translate and design oligos in regions of low degeneracy automatically. • Nested/multiplex- Checking homology among multiple candidate oligos. • Restriction enzyme and motif analysis- Select from the database of over 800 enzymes and 200 common motifs. • Long PCR- Handles sequences up to 50 KB.
	Z730548	SimGlycan software	Accurate Glycan Structure Prediction SimGlycan predicts the structure of a glycan from the MS/MS data acquired by mass spectrometry, facilitating the study of glycosylation and post translational modification studies. SimGlycan accepts the experimental MS profiles generated by a mass spectrometer, matches them with its own database of theoretical fragmentation of over 7,000 glycans and generates a list of probable glycan structures. Each structure is scored to reflect how closely it matches your experimental data. Other biological information for the probable glycan structures such as the glycan class, reaction, pathway and enzyme are also made available for easy reference. Glycan Mass Spectrometry Identification Tool SimGlycan is an innovative glycan mass fingerprinting tool. SimGlycan predicts the glycan structure, scores it and generates a list of probable glycans that closely match the your experimental MS profile saving you the time and the frustration of laborious work. Glycan Mass Fingerprinting for Studying Glycosylation and Post Translational Modifications Glycosylation is the result of addition of a glycan to a protein and represents the most common of all the known protein post-translational modifications. Carbohydrates have been found to participate in many biological processes including embryonic development, inter and intracellular activities, coordination of immune functions, pathogens homing on their host tissues, cell division processes and protein regulations and interactions. For facilitating such studies, SimGlycan predicts the structure of a glycan from the MS/MS data acquired by mass spectrometry. SimGlycan accepts the experimental MS profiles generated by a mass spectrometer, matches them with its own theoretical fragmentation database and generates a list of probable glycan structures. Each structure is scored based on how closely it matches your experimental data. Additional known biological information for the structures such as glycan class, reaction, pathway and enzyme is displayed, saving you from having to retrieve it from many sources. Robust Glycan Database The SimGlycan database is a large relational database populated with theoretical fragments of known glycan structures made up of 42 different monosaccharides. Every glycan in the database is fragmented for each of the possible thirty four reaction conditions using an intensive fragmentation algorithm. This ensures that the probable glycan fragments reported are comprehensive and accurate. Every effort has been made while populating this database to make it extremely high quality, enabling reliable data mining for future applications of glycobiology. SimGlycan database supports 8178 glycans, 7526 biological sources, 3498 glycan compositions, 5406 classes, 196 biochemical reactions, 148 biochemical pathways, 177 enzymes and 7234 database links. References Domon and Costello, (1988),"A Systematic Nomenclature for carbohydrate fragmentations in FAB-MS/MS Spectra of Glycoconjugates”, Glycoconjugate 5:397-409. David J. Harvey,"Collision-induced fragmentation of negative ions from N-linked glycans derivatized with 2-aminobenzoic acid ", Journal of Mass Spectrometry, 5: 42-653. Wuhrer M and Deelder AM,(2006),"Matrix-assisted laser desorption/ionization in-source decay combined with tandem time-of-flight mass spectrometry of permethylated oligosaccharides: targeted characterization of specific parts of the glycan structure", Rapid Commun. Mass Spectrom. 20: 1–9. Morelle W, SlomiannyMC, Diemer H, Schaeffer C, Dorsselaer AV and Michalski JC, (2004)," Fragmentation characteristics of permethylated oligosaccharides using a matrix-assisted laser desorption/ionization two-stage time-of-flight (TOF/TOF) tandem mass spectrometer", Rapid Commun. Mass Spectrom. 18: 2637–2649.
	S9813	SimVector	An exceptional software to design cloning experiments and drawing publication quality plasmid vector maps • Web integration - Automatically connects to Entrez for sequence retrieval • Graphical Entrez features - Transforms GenBank annotations to graphical features • Web ready images - Outputs images in JPEG format for addition to web sites • Publication quality images - Outputs images in high resolution TIFF format for publication • Plan cloning experiments - Designs PCR TA cloning, restriction enzyme, and Cre recombinase cloning experiments • Sequence editing - Easily place inserts in vectors by cutting and pasting • Active analysis - Automatically updates enzymes and features as a DNA sequence is edited • Easy styling - Hundreds of fonts, colors, styles and fill patterns for enzymes and features • Marquee select - Group select objects to quickly set styles for all • Automatic overlap avoidance - Built in algorithm keeps enzymes and feature labels from overlapping • Linear and circular views - Produces both circular and linear graphical maps • Zooming - Zoom in for detailed graphics or out for an overview • Folders - Keep all sequence files organized by lab, researcher, or project • Sequence import - Move sequence files from computer to computer or e-mail over the Internet. • Comprehensive database - Analyzes for restriction sites with database of more than 900 enzymes • Enzyme Filtering - Select restriction enzymes by overhang, recognition site length, etc. ·
	Z704547	TL 100 (TotalLab)	TotalLab is a highly automated and flexible image analysis software package. It offers the complete solution for all your general image analysis requirements across a wide range of applications. There are modules for: • 1D electrophoresis gel analysis - Single click identification of lanes and bands, and accurate calculation of molecular weights from even the most distorted 1D images. • Array analysis - Ideal for the quantitative analysis of dot and slot blots, microtitre plates and other basic arrays, creating grids of up to 1,536 cells. • Colony counting - Accurate counts in seconds, adjustable parameters and editing tools if fine tuning is required. • General image analysis using Toolbox - General quantitation on any image from a wide range of biological samples using the easy-to-use range of tools provided. The analysis work-flow within the modules is the same throughout. The interface follows a wizard-style making it easy for you to navigate through the analysis, there are Help Panes at each stage and parameters for the analysis are easily accessible to assist with the refinement of the analysis.
	Z704555	TL 120 (Phoretix 1D)	This is advanced analysis software that enables detailed and in-depth analysis of 1D electrophoresis gels including large format gels and gels containing multi-tiers. The TL120 version in the TotalLab range is an advanced image analysis solution which offers an extensive range of features for the in-depth analysis of 1D electrophoresis gels and performing band pattern matching studies. • Offers a flexible and intuitive workflow • Contains highly-sophisticated algorithms to cope with the most demanding analysis • Enables Rf calibration which drives highly accurate molecular weight determination • Provides an extensive range of tools for accurate quantitation and normalization • Performs precise band pattern matching • Contains advanced visualisation and reporting tools
	Z704911	Xpression Primer	A revolutionary tagged primer design tool for expression cloning. • High throughput primer design- Use Xpression Primer's sophisticated algorithm to design thousands of primers in a single search run. The program uses statistical optimization techniques to select the best primer pair for each sequence based on your selection criteria. • Extensive Assay Support- Xpression Primer provides comprehensive support to high throughput cloning systems such as Gateway™, BD In-Fusion, epitope and TOPO™ tools. To work with other expression systems, add functional tags of your choice and design tagged primers. • Sophisticated Sequencing Primer design- Xpression Primer designs optimal primers for multiples sequences in a single search run. • Generate Precise transcripts- Design primers to generate sense or antisense transcripts for in vitro expression studies. • Web Savvy- Xpression Primer searches Entrez and downloads batches of ORF sequences directly into the program. • Lightning fast- Processes three hundred 10kb sequences in approximately 2 minutes.

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