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Description
Biochem/physiol Actions
CAS Number
Product #
(−)-Cotinine ~98%
Major metabolite of nicotine in humans.
486-56-6
C5923
(±)-Vesamicol hydrochloride >98%, solid
Potent inhibitor of vesicular acetylcholine storage.
120447-62-3
V100
14-Acetylvirescenine from
Delphinium
sp. ≥99% (TLC), white powder
Blocks the propagation of the action potential at the nicotinic cholinoreceptors of vegetative ganglia and neuro-muscular junctions. Hypotensive and curare-like action, I.V. and orally.
A6472
Acetylethylcholine mustard hydrochloride >97% (GC), solid
Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.
103994-00-9
C001
Aminobenztropine solid
High affinity muscarinic ligand that has been used for affinity purification of muscarinic cholinergic receptors.
A138
Bromoacetylcholine bromide
22004-27-9
B121
Choline bitartrate
Acyl group acceptor
87-67-2
C1629
Choline chloride reagent grade, ≥98%
Acyl group acceptor
67-48-1
C1879
Choline-
13
C
1
bromide (
methyl-
13
C
1
) 99 atom %
13
C
488593
Dithiobiuret 97%, solid
541-53-7
D3190
Hemicholinium-3 solid, ≥95% (HPLC)
Potent and selective choline uptake blocker.
312-45-8
H108
Linopirdine ≥98% (HPLC)
Stimulates release of acetylcholine and other neurotransmitters; cognitive enhancer.
105431-72-9
L134
Phenserine ≥98% (HPLC), solid
(-)-Phenserine, a phenylcarbamate derivative, is a selective, non-competitive inhibitor of acetylcholinesterase (AChE). (-)-Phenserine produces rapid, potent, and long-lasting AChE inhibition,
in vivo
. It is significantly less toxic than (-)-physostigmine. (-)-Phenserine improves cognitive performance in both young learning-impaired and elderly rats. Reduced secretion of β-amyloid (Abeta) has been observed in cell lines exposed to (-)-phenserine, occurring through translational regulation of β-amyloid precursor protein (beta-APP) mRNA via a non-cholinergic mechanism. These
in vitro
findings appear to translate
in vivo
into animal models and humans.
101246-66-6
P0111
Tropine 2-(phenylthio)butanoate oxalate salt ≥98%
Potent analgesic. Causes increased release of acetylcholine at central muscarinic synapses.
155059-55-5
T7556
WB64 solid
Ligand for allosteric site of the M
2
muscarinic receptor.
W4761
α-Bungarotoxin-
tetramethylrhodamine from
Bungarus multicinctus
(Formosan Banded Krait)
Useful for detecting the distribution of nicotinic acetylcholine receptors at neuromuscular junctions.
T0195
β-Bungarotoxin from
Bungarus multicinctus
(Formosan Banded Krait)
Phospholipase A
2
neurotoxin
; destroys synaptic vesicles and inhibits acetylcholine release.
T5644
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