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Agonists

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Description
Biochem/physiol Actions
CAS Number
Product #
(−)-Lobeline hydrochloride 98% 134-63-4 141879
(−)-Nicotine hemisulfate salt ≥95% (TLC), ~40 % (w/v) in H2O (based on free base) Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
 65-30-5 N1019
(−)-Nicotine hydrogen tartrate salt ≥98% (TLC), powder Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
 65-31-6 N5260
(−)-Nicotine ≥99% (GC), liquid Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
 54-11-5 N3876
(±)-Anabasine ≥90% (TLC), liquid Tobacco alkaloid; potent nicotinic acetylcholine receptor agonist.
 13078-04-1 A5656
(±)-Epibatidine dihydrochloride hydrate ≥98% (HPLC), powder The activity of epibatidine at neuronal and neuromuscular nicotinic acetylcholine receptors was compared with the activity of nicotine and suxamethonium. Activation of ganglionic nicotinic receptors by epibatidine was shown in the guinea-pig ileum (contraction mediated by the cholinergic neurons of the ileum) and in pithed and atropinized rats (rise in blood pressure). Epibatidine also activated nicotinic receptors at the peripheral terminals of afferent C-fibres (rabbit ear) and in the brain (antidiuresis in rats). The agonistic effects of epibatidine were followed by long-lasting receptor desensitization. No antinociceptive effect of epibatidine was seen in rats at a dose free of motor impairment. On muscle end plate nicotinic receptors of the rat diaphragm (not responding to depolarizing agents by contraction), epibatidine was equipotent with suxamethonium in causing neuromuscular inhibition. On an extraocular muscle of the rabbit (responding to depolarizing agents by contraction) epibatidine in vitro and in situ caused a contraction at a 100-fold lower dose than suxamethonium. The Straub tail reaction in mice to epibatidine could be attributed to the sustained stimulation of motor end plate receptors of the "slow contracting" type of muscle fibres by epibatidine. Epibatidine was the most potent agonist on all neuronal and neuromuscular nicotinic receptors examined.
 E1145
(±)-Muscarine chloride ≥98% Muscarinic acetylcholine receptor agonist; originally isolated from Amanita muscaria.
 2936-25-6 M104
(±)-Nicotine ≥98% (TLC), liquid Prototype nicotinic acetylcholine receptor agonist.
 22083-74-5 N0267
(±)-Nornicotine ≥99% (TLC), liquid Nicotinic acetylcholine receptor agonist; active metabolite of nicotine; tobacco alkaloid.
 5746-86-1 N3018
(+)-Muscarine chloride ~95% (TLC), powder Prototype muscarinic acetylcholine receptor agonist; active enantiomer.
 2303-35-7 M6532
1,1-Dimethyl-4-phenylpiperazinium iodide ≥98% (TLC or titration), powder Nicotinic acetylcholine receptor agonist.
 54-77-3 D5891
A-85380 dihydrochloride solid Potent and selective neuronal nicotinic acetylcholine receptor (nAChR) agonist.
 A251
ABT-418 hydrochloride powder, ≥98% (HPLC) Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.
 147388-83-8 A6476
Acetyl-β-methylcholine chloride ≥98% (TLC), powder Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.
 62-51-1 A2251
Acetylcholine bromide ≥99% Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.
 66-23-9 A6500
Acetylcholine chloride ≥99% (TLC) Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.
 60-31-1 A6625
Acetylcholine chloride BioChemika, ≥99.0% (AT) Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.
 60-31-1 01018
Acetylcholine iodide Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.
 2260-50-6 A7000
Acetylcholine perchlorate 927-86-6 A2394
Acetylthiocholine chloride ≥99% (TLC), powder Acetylcholinesterase substrate and nicotinic acetylcholine receptor agonist.
 6050-81-3 A5626
Acetylthiocholine iodide ≥98% (TLC), powder 1866-15-5 A5751
Arecaidine propargyl ester hydrobromide solid Potent muscarinic acetylcholine receptor agonist exhibiting slight selectivity for M2 receptors; inactive at nicotinic receptors.
 116511-28-5 A140
Carbamoylcholine chloride ≥98% (titration), crystalline Non-selective cholinergic agonist that is resistant to the action of cholinesterases; inhibits apoptotic death of cultured neurons, and may induce apoptosis in thymocytes.
 51-83-2 C4382
Carbamyl-β-methylcholine chloride ≥99% (TLC), crystalline 590-63-6 C5259
Cisapride monohydrate ≥98% (HPLC), solid 5-HT4 serotonin receptor agonist.
 260779-88-2 C4740
Cytisine ≥99%, powder Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors.
 485-35-8 C2899
DBO-83 solid Novel nicotinic acetylcholine receptor agonist, structurally related to epibatidine, with antinociceptive properties in rodents.
 195211-53-1 D7938
Decamethonium bromide crystalline Nicotinic acetylcholine receptor partial agonist and neuromuscular blocking agent; depolarizes striated muscles and blocks their activity.
 541-22-0 D1260
Epiboxidine hydrochloride Potent nicotinic acetylcholine receptor agonist; analog of epibatidine
 188895-96-7 E152
McN-A-343 ≥98% (TLC), powder M1 muscarinic acetylcholine receptor agonist.
 55-45-8 C7041
Muscarinic Toxin-2 from Dendroaspis angusticeps venom ≥98% (SDS-PAGE), lyophilized powder M1 and M4 muscarinic acetylcholine receptor agonist.
 M8058
O-Acetyl-L-carnitine hydrochloride ≥99% (titration), powder Endogenous mitochondrial metabolite that transports acetyl groups across the mitochondrial membrane. Exogenous acetylcarnitine enhances mitochondrial function in aged rats. As an acetate donor to coenzyme A, it increases the central and peripheral acetylcholine synthesis and function. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors.
5080-50-2 A6706
Oxotremorine sesquifumarate salt ≥98% (HPLC), solid Oxotremorine sesquifumarate salt is a muscarinic acetylcholine receptor agonist with preference for the M2 receptor.
 17360-35-9 O9126
Oxotremorine M solid Nonselective muscarinic acetylcholine receptor agonist.
 63939-65-1 O100
PNU-282987 hydrate solid, ≥98% (HPLC) Decreased expression of a homomeric alpha7 nicotinic acetylcholine receptor (nAChR) is connected with inability to process sensory information in schizophrenia. PNU-282987 is a novel selective agonist of the alpha7 nAChR that evoked whole-cell currents from cultured rat hippocampal neurons that were sensitive to the selective alpha7 nAChR antagonist methyllycaconitine (MLA) and enhanced GABAergic synaptic activity. The alpha7 nAChR agonist PNU-282987 improves auditory gating and enhances hippocampal oscillatory activity. These results provide further support for the concept that drugs that selectively activate alpha7 nAChRs may offer a novel, potential pharmacotherapy in treatment of schizophrenia.
 P6499
Pilocarpine hydrochloride ≥98% (titration), powder Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.
 54-71-7 P6503
Pilocarpine nitrate salt ≥98% (TLC), powder Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.
 148-72-1 P6628
RJR-2403 hemigalactarate ≥98% (HPLC), powder Neuronal nicotinic acetylcholine receptor agonist that displays CNS activity.
 183288-99-5 R130
RJR-2429 dihydrochloride solid Nicotinic acetylcholine receptor agonist.
 R131

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